331994 RESULTS
RESEARCH NEWS 2024-05-09 Research News The Alzheimer’s risk gene phospholipase C-γ2 has been thought to act mainly in microglia. Now, in a May 1 preprint on bioRxiv, researchers led by Jean-Charles Lambert, Julie Dumont, and Julien Chapuis at Institut Pasteur de Lille, France, Mi
COMMENT This study by Coulon et al. is a tour de force, identifying and characterising an exciting neuronal function for the AD gene PLCγ2, which encodes a phospholipase enzyme involved in signal transduction. The multilaboratory team established a loss-of-functi
PAPER Xu X, Wen X, Bhimani S, Moosa A, Parsons D, Ha H, Jin T
PAPER Xia Z, Storm DR
PAPER Coulon A, Rabiller F, Takalo M, Roy A, Martiskainen H, Siedlecki-Wullich D, Mendes T, Lemeu C, Carvalho L-I, Ehrardt A, MelodeFerias AR, Hulsman M, Najdek C, Lannette-Weimann N, Freire-Regatillo A, Amouyel P, Charbonnier C, Dols-Icardo O, Jeskanen H, Kuulasmaa T, Kurki M, Hardy J, Wagner M, Heikkinen S, Holstege H, Makinen P, Nicolas G, Mead S, Wagner M, Ramirez A, Rauramaa T, Palotie A, Sims R, Soininen H, vanSwieten J, Williams J, Willman R-M, Bellenguez C, Grenier-Boley B, Gelle C, Lambert E, Ayral A-
COMMENT It is well known that certain subcortical modulatory nuclei, including the pigmented pontine nucleus locus coeruleus (LC), exhibit very early tau cytoskeletal pathology. According to earlier large-scale and detailed neuropathological studies by Heiko Braa
COMMENT It is exciting to see the first paper investigating longitudinal locus coeruleus (LC) integrity and longitudinal tau-PET in vivo! Bueichekú and colleagues expanded on their previous pioneering studies. In a cohort of almost all cognitively unimpaired olde
COMMENT The is another in a series of articles discussing the integrity of locus coeruleus norepinephrine projection neurons and cortical tau pathology and cognition in Alzheimer’s disease. The authors examined whether LC changes precede tau deposition in the med
RESEARCH NEWS 2024-05-09 Research News Cross-sectional autopsy studies have suggested that, in Alzheimer’s disease, neurofibrillary tangles first appear in the locus coeruleus (LC) of the brainstem. Now, a longitudinal imaging study lends support to that theory. In the April 25 N
Clayton, United States
COMMENT The noradrenergic locus coeruleus (LC) is among the first regions in the brain to accumulate hyperphosphorylated tau pathology, prior to the medial temporal lobe (MTL) and the cortex, in the prodromal stages of Alzheimer’s disease (AD). Because the LC pro
COMMENT This paper is very important for the field in several aspects. It builds logically from the beautiful work that Heidi Jacobs has been doing on the importance of the neuromodulatory subcortical system, with a special focus in the locus coeruleus in AD prog
COMMENT Bueichekú and colleagues conducted a study using multiple imaging biomarkers, including a 3T MRI sequence dedicated to locus coeruleus (LC) quantification, as well as amyloid and tau PET. They showed that LC integrity predicted longitudinal tau PET accumu
Portage, United States
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