Could APP, Not Aβ, Explain Epileptic Activity in Alzheimer’s?

RESEARCH NEWS 2014-03-14 Research News People with Alzheimer’s run a high risk for seizures, as do mice that model the disease. While Aβ has seemed the most likely cause for this neuronal hyperactivity, a study in the March 12 Journal of Neuroscience suggests that the Aβ precurso

PAPER Klaassen A, Glykys J, Maguire J, Labarca C, Mody I, Boulter J

Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy.

Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19152-7. Epub 2006 Dec 4 PubMed: 17146052

Cdk5 Controls Memory Switch in Neurons

RESEARCH NEWS 2014-03-14 Research News Young brains soak up experiences like sponges, but with age new material becomes harder to learn. Is there a way to turn back the clock? Perhaps so, according to a paper in the March 5 Neuron. Researchers led by James Bibb at the University

PAPER Plattner F, Hernández A, Kistler TM, Pozo K, Zhong P, Yuen EY, Tan C, Hawasli AH, Cooke SF, Nishi A, Guo A, Wiederhold T, Yan Z, Bibb JA

Memory enhancement by targeting Cdk5 regulation of NR2B.

Neuron. 2014 Mar 5;81(5):1070-83. PubMed: 24607229

PAPER Tang YP, Shimizu E, Dube GR, Rampon C, Kerchner GA, Zhuo M, Liu G, Tsien JZ

Genetic enhancement of learning and memory in mice.

Nature. 1999 Sep 2;401(6748):63-9. PubMed: 10485705

Cara Westmark on Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease.

COMMENT Born and colleagues present an elegant study demonstrating that juvenile overexpression of APP contributes to sharp wave discharges in EEG using a tetracycline-responsive APP transgenic mouse model with a humanized Aβ domain encoding both the Swedish and

PAPER Born HA, Kim JY, Savjani RR, Das P, Dabaghian YA, Guo Q, Yoo JW, Schuler DR, Cirrito JR, Zheng H, Golde TE, Noebels JL, Jankowsky JL

Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease.

J Neurosci. 2014 Mar 12;34(11):3826-40. PubMed: 24623762

Amyvid Follows in PiB’s Footsteps

RESEARCH NEWS 2014-03-14 Research News Florbetapir, an FDA-approved PET tracer that detects amyloid in the brain, predicts global and cognitive decline much like its predecessor, Pittsburgh compound B (PiB), according to a new study. Scientists led by Murali Doraiswamy, Duke Univ

Roberta Ferretti

Tamara Donahue

Washingto University in St. Louis
Saint Louis, United States

Stella Hurtley

Science
CAMBRIDGE, United Kingdom

Phoebe Favie

Nathalie Pierrot

Université catholique de Louvain Institute of Neuroscience
Brussels

PAPER Fabelo N, Martín V, Marín R, Moreno D, Ferrer I, Díaz M

Altered lipid composition in cortical lipid rafts occurs at early stages of sporadic Alzheimer's disease and facilitates APP/BACE1 interactions.

Neurobiol Aging. 2014 Aug;35(8):1801-12. Epub 2014 Feb 11 PubMed: 24613671

PAPER García-Ayllón MS, Campanari ML, Montenegro MF, Cuchillo-Ibáñez I, Belbin O, Lleó A, Tsim K, Vidal CJ, Sáez-Valero J

Presenilin-1 influences processing of the acetylcholinesterase membrane anchor PRiMA.

Neurobiol Aging. 2014 Jul;35(7):1526-36. Epub 2014 Feb 6 PubMed: 24612677