Wennström M, Surova Y, Hall S, Nilsson C, Minthon L, Boström F, Hansson O, Nielsen HM. Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy. PLoS One. 2013;8(1):e53250. Epub 2013 Jan 8 PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : α-synuclein (CSF)
- CTRL vs AD : α-synuclein (CSF)
- DLB vs AD : α-synuclein (CSF)
- PDD vs AD : α-synuclein (CSF)
- PD vs AD : α-synuclein (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| α-synuclein (CSF) |
AD (46) |
795.914 ± 218.85 pg/mL § |
ELISA; Other/Not Specified; Invitrogen |
McKhann et al., 1984 |
| α-synuclein (CSF) |
CTRL- CNC (52) |
695.014 ± 243.746 pg/mL § |
ELISA; Other/Not Specified; Invitrogen |
|
| α-synuclein (CSF) |
DLB (33) |
596.542 ± 210.546 pg/mL § |
ELISA; Other/Not Specified; Invitrogen |
McKeith et al., 2005 |
| α-synuclein (CSF) |
PD (38) |
570.211 ± 173.799 pg/mL § |
ELISA; Other/Not Specified; Invitrogen |
Gelb et al., 1999 |
| α-synuclein (CSF) |
PDD (22) |
551.847 ± 158.471 pg/mL § |
ELISA; Other/Not Specified; Invitrogen |
§ Data supplied to Alzforum by author
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