Human CSF Aβ Oligomers—Toxic But Controllable
Aβ oligomers made in test tubes or found in conditioned cell-culture medium can put a damper on synaptic plasticity...
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Aβ oligomers made in test tubes or found in conditioned cell-culture medium can put a damper on synaptic plasticity...
One of the big surprises at this year’s Human Amyloid Imaging meeting was the finding that a significant proportion of healthy controls are PIB-positive...
A new approach to detoxifying the amyloid-β (Aβ) peptide borrows from an unlikely source—the field of cancer drugs...
Is it time to redefine ALS?...
Increasing brain expression of the endogenous opioid peptide may contribute to the cognitive impairment triggered by Aβ production...
Two papers out this week focus on synapses, their contents and function, and how amyloid-β (Aβ) might play into both...
Researchers in Germany and the U.S. debut a new type of light microscopy...
Mice with a defect in a mitochondrial dehydrogenase enzyme show age-related neurodegeneration...
An anti-inflammatory drug has shown therapeutic promise in a mouse model of Alzheimer disease...
Alternative splicing of messenger RNAs can result in the production of protein isoforms with different functions...
People affected by early-onset familial forms (eFAD) often wonder how discoveries apply to them...
In mammals, molecular chaperones may help stave off neurodegenerative disease by steering proteins away from abnormal, toxic conformations...
Showing that an experimental Alzheimer’s therapy delivers meaningful cognitive change is hard enough...
Robert Katzman, a leader in the field of Alzheimer’s research, died at his home in La Jolla, California, last week...
Mouse models and biochemical studies have implicated protein phosphatase 2A (PP2A) in curbing tau hyperphosphorylation in Alzheimer and other diseases...