Research Brief: Lucky Seven—Htt N-Terminal Structure Solved
Like preschool teachers trying to arrange squirmy youngsters into a straight line, structural biologists spend days, even years, taming the unruly...
6401 RESULTS
Sort By:
Like preschool teachers trying to arrange squirmy youngsters into a straight line, structural biologists spend days, even years, taming the unruly...
In AD immunotherapy research, the peripheral sink hypothesis claims that certain antibodies help drain the peptide from the central nervous system...
Yesterday, Nature Genetics online released full reports of the two largest genomewide association studies of sporadic Alzheimer disease performed to date..
A gene involved in neurotransmitter regulation is the latest addition to the handful of genetic loci linked to amyotrophic lateral sclerosis in genomewide association studies...
Pushing the limits of light and electron microscopy, two new studies promise to open up ever more detailed nano-vistas into cells and tissues...
Proposed causes of Alzheimer disease may abound in the scientific literature, but many focus on a common endpoint: sputtering synapses that spell death for neurons...
Many researchers studying neurodegenerative disease focus their studies on the affected organs of the nervous system. But in doing so, they may be ignoring a more accessible place...
Imaging the brain through ultra-thin bone windows into the brains of live mice, scientists see in vivo that amyloid plaques form and reach their full size over a period of weeks...
Researchers have identified age-dependent learning problems that seem to stem from defects in synaptic function...
For a motor neuron to maintain the unwieldy meter-long axons that innervate the lower limbs requires all the cell’s parts to work together perfectly...
Building a healthy axon, like erecting a skyscraper, takes a variety of workers and materials...
Hopes of bringing M1’s therapeutic potential to the clinic have resurged with recent data hinting at better success by targeting allosteric sites...
How does a nice (that is, soluble and relatively unstructured) protein like tau end up rigidly locked into paired helical filaments and neurofibrillary tangles?...
As is true with getting into college or receiving a job offer, it’s not just pedigree but also life experiences that may determine whether a person will develop Alzheimer disease...
The idea that natural variants of a single gene could substantially influence brain structure might blow your mind...