ApoE3 Christchurch Clings Tightly to Tau, Averting Tangles
In AD mouse models, replacing ApoE3 with ApoE3Ch preserves memory.
NEWS
Leqembi Maintenance Dosing Approved in the U.S.
The nod will allow people who have completed 18 months of biweekly IV dosing to transition to monthly IVs. An application for subcutaneous dosing is pending.
C-Terminal Amidation Sends Proteins to the Shredder
Triggered by oxidative stress, this degradation signal may protect neurons.
Cell-Based Assay Matches Tau Strains to Neuropathological Diagnosis
By tracking how mutations influence the incorporation of monomers, scientists pinpoint which residues shape tau fibrils.
Blame Mom? Maternal X Chromosome Worsens Memory
In female mice, the silencing of several cognitive genes on maternally inherited X chromosomes correlated with poor memory; re-expressing the genes improved it.
Can the Kidneys Kickstart Parkinson’s?
In people with PD and other Lewy body diseases, α-synuclein accumulates in the kidneys, scientists say. In mice, it spreads from there to the brain.
“iAssembloids” Probe Glial Roles in Neuron Survival
New 3D model shows how a tau kinase and Apoe4 astrocytes kill neurons through oxidative stress.
Plaques Spur Spread of Tangles by Sending Synapses into Overdrive
Hyperconnectivity ushers tangles from temporal lobe to posterior cortex. Study could revive interest in trialing anti-convulsants with tau biomarkers as an outcome.
SPOTLIGHT
Blame Mom? Maternal X Chromosome Worsens Memory
It turns out parents matter when it comes to X chromosomes. Female mice that express genes from only the maternal X did worse on memory tests than those with a balance of maternal and paternal X chromosome expression. Why? Scientists traced the effect to the silencing of several genes on the maternal X. Activating those genes in female mice bolstered memory, suggesting they play a role in cognition.
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