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The Pathogen Hypothesis

June Kinoshita, with Brian Balin, Denah Appelt, Joseph Lyons, Ruth Itzhaki, and Curtis Dobson, led this live discussion on 1 July 2004. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.   Itzhaki RF, ...

Webinar: Cortex Aging Too Fast? Blame TMEM106B and Progranulin

If age is the strongest risk factor for Alzheimer’s and other neurodegenerative diseases, how come some nonagenarians stay sharp while others lose their edge? Genetics beyond the known genes linked to pathologies, such as amyloid plaques and ...

Webinar: Pathogenic Protein Spread? Let’s Think Again

Multiple lines of evidence have converged on the idea that toxic variants of Aβ, α-synuclein, and tau worm their way from one cell to the next, seeding the misfolding and aggregation of normal proteins as they go. In this manner, a growing number of ...

Who Should Use the New Diagnostic Guidelines? The Debate Continues

Download a PDF of this Forum Discussion Ever since new criteria came out for a research diagnosis of prodromal/preclinical Alzheimer’s disease, plus criteria for a research and clinical diagnosis of the MCI and dementia stages of the disease, they have ...

What Price Privacy? Is the HIPAA Law Stifling Dementia Research?

Are you a dementia epidemiologist trying to access patient records so you can puzzle out disease associations? Are you a clinical investigator trying to recruit patients to a trial? Are you a professional dementia care provider trying desperately to spend ...

Herpes Simplex and Alzheimer’s—Time to Think Again?

On Thursday, 24 February 2011, Ruth Itzhaki, University of Manchester, U.K.; Elisa Porcellini, University of Bologna, Italy; Luc Letenneur, INSERM, Bordeaux, France, and Richard Smeyne, St. Jude Children’s Research Hospital, Memphis, Tennessee, shared ...

Are Glia Active Participants in Neurodegenerative Disease?

Ben Barres led the first in a series of Alzforum discussions about the role of glial cells in Alzheimer’s and other neurodegenerative diseases. It has become trendy to say that glia are more than just glue, but in reality, science has not yet advanced ...

Updated Diagnostic Criteria and Management of Lewy Body Dementia

Despite being arguably the second most common dementing disorder, dementia with Lewy bodies, aka DLB, remains both mysterious and understudied.  On Tuesday, October 10, 2017, the Lewy Body Dementia Association and Alzforum co-hosted a webinar discussion ...

Is Alzheimer’s Disease a Uniquely Human Disorder?

Humans are not alone in accumulating Aβ in their brain. Squirrel monkeys, vervets, lemurs, apes, other nonhuman primates, and even dogs develop copious amyloid plaques and cerebral amyloid angiopathy as they age. However, most animals are spared the ...

Neuroinflammation—A Prelude to Alzheimer's?

Neuroinflammation plays a major role in Alzheimer's disease, but whether it represents a cause or a response to pathology is unclear. In the November 27 Nature Reviews Neurology, Dimitrije Krstic and Irene Knuesel argue that age-related chronic ...

Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.

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