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Could the protein aggregates that cause neurodegeneration turn out to be the cellular equivalent of ice cubes? Scientists investigating how proteins naturally transition between gas-like solutions, condensed liquids, solidified gels, and insoluble fibrils ...
On 4 April 2013, the Alzheimer's Disease Neuroimaging Initiative biostatistics core held the first session of its two-part online training course on using ADNI data. Led by Danielle Harvey of the University of California, Davis, the session gave a ...
What makes a good grant proposal in Alzheimer’s research? How to develop and present it? What are funders looking for? Students from all over the world learned the answers by working hands-on with established Alzheimer’s disease researchers at a workshop ...
Over the years, γ-secretase has garnered intense interest from scientists and drug developers who have targeted the multimeric complex in an attempt to curb production of amyloid-β (Aβ), the peptide believed to underlie Alzheimer’s disease. Meanwhile, the ...
Download a PDF of this Forum Discussion Ever since new criteria came out for a research diagnosis of prodromal/preclinical Alzheimer’s disease, plus criteria for a research and clinical diagnosis of the MCI and dementia stages of the disease, they have ...
On 16 June 2011, ARF held a Webinar with Eddie Lee, Todd Golde, Gunnar Gouras, Frank LaFerla, Virginia Lee, Lars Nilsson, and Robert Vassar to discuss this study’s implications for intraneuronal Aβ and its role in AD pathogenesis. The Guest Moderator was ...
Our thanks to the Journal of Gerontology for granting permission to post the full text article. Natalie Rasgon led this live discussion on 6 July 2005. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. ...
In a paper just published in the inaugural issue of the new journal, Alzheimer's & Dementia, Claudio Costantini, Rekha Kolasani, and Luigi Puglielli argue that the lipids ceramide and cholesterol may provide metabolic links between AD and aging. ...
Children born with Down’s syndrome can receive excellent healthcare at specialized clinics, but once they become adults, their care often falls to doctors who may be less qualified to deal with their specific needs. The new Down Syndrome Center for ...
In this Webinar, Paul Aisen gave a slide talk followed by a panel discussion with Reisa Sperling and Lon Schneider, clinician-researchers and members of the ADCS Steering Committee; Randall Bateman, clinical core leader of DIAN, who is planning drug ...
This live discussion was held on the paper by O'Doherty et al., in Science, on "An aneuploid mouse strain carrying human chromosome 21 with down syndrome phenotypes." Lizzy Fisher and Victor Tybulewicz led this live discussion on 14 October ...
Are you confused about the various forms of PET and MRI that are used to image the brain? Do you know which protocol is more suited to detecting plaques and which can measure brain activity? Are you concerned when you see images of shrinking brains? Do ...
Ever since amyloid-β (Aβ) was identified as the major component in amyloid plaques, scientists have been trying to decipher just exactly what the little peptide does. Most researchers would agree that Aβ is toxic to cells, but some are still skeptical. ...
There is now a concerted push in the research community to find pharmacological and/or non-pharmacological interventions that can prevent or slow the progression of Alzheimer disease. But prevention trials promise to be long and potentially costly affairs ...
Cognitive stimulation has been shown to lower the risk of Alzheimer’s disease, but what actually happens in the brain to confer protection? In the March 6 Neuron, researchers led by Dennis Selkoe report that β2-adrenergic signaling plays a key role. Wild ...
Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.
