Researchers rely on transgenic mice to model Alzheimer's disease, but these models are far from perfect. Some can only be maintained on specific genetic backgrounds, some die young or have surprising phenotypes when crossed with other mouse lines, ...
Paul Coleman, with Carl Cotman, Mark A. Smith, and George Perry, led this live discussion on 24 March 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held 24 March ...
Dr. Coleman led this live discussion on how biomarker information and basic science of AD can inform each other. He reviewed how the more common biomarkers of tau and Aß peptides relate to the major neurobiological deficits in AD—synaptic loss and ...
Katrina Gwinn-Hardy led this Web seminar and discussion on the whole genome study of Parkinson disease which was published recently in Lancet Neurology. Co-author Gwinn-Hardy presented the findings and introduced some discussion topics around data sharing ...
Ben Wolozin of the Boston University School of Medicine presented some results from analyzing a 4.5 million-subject database of medical records to identify medications that are associated with reduction or increase in the incidence of dementia. His team& ...
Marc Paradis led this live discussion on 20 March 1998. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Paper under Discussion: Li JH, Xu M, Zhou H. Ma J. and Potter H. Alzheimer presenilins in the ...
On 5 March 2009, we held a Webinar/Live Discussion with a slide presentation by Scott Small and Karen Duff, and a subsequent panel discussion with John Morris at Washington University, St. Louis; Michael Wolfe of Brigham and Women's Hospital, Boston; ...
At first blush, Alzheimer disease and fragile X syndrome may appear as chalk and cheese, since the former is a neurodegenerative disease and the latter a developmental disorder. However, both are characterized by synaptic pathology and as exemplified by a ...
This background text was prompted by an article in the Journal of Medical Ethics by Udo Schuklenk questioning ethical implications of scientific dissent. George Perry led this live discussion on 10 March 2004. Readers are invited to submit additional ...
Deborah Watson and Kenneth Kosik led this live discussion on 30 January 1998. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Paper Under Discussion: De Strooper B, Saftig P, Craessaerts K, ...
Debra Revere discussed how the tools developed by the Telemakus Research Group have been used to extract research methods, animal models, data from tables and figures, and research results from published literature. View Presentation You will need ...
Are you a dementia epidemiologist trying to access patient records so you can puzzle out disease associations? Are you a clinical investigator trying to recruit patients to a trial? Are you a professional dementia care provider trying desperately to spend ...
Scientists have uncovered hundreds of genetic variants that purportedly cause familial forms of various neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementias, and amyotrophic lateral sclerosis. But are all of these ...
John C. Morris, Murray Raskind, and Martin Farlow led this live discussion on 14 October 2003. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: John C. Morris, M.D. led this live ...
Our thanks to Practical Neurology for granting permission to reprint the full text of a recent article (.pdf) by John Trojanowski. John Trojanowski, Les Shaw, and Anne Fagan led this live discussion on 1 June 2005. Readers are invited to submit additional ...
Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.