Protein Folding and Neurodegeneration: Biophysics to the Rescue?

30 Apr 2003

David Teplow led this live discussion on 30 April 2003. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.    See also David Thirumalai's Emerging Ideas on the Molecular Basis of Protein and ...

Isolation of Single Immunohistochemically Identified Whole Neuronal Cell Bodies from Post-Mortem Human Brain for Simultaneous Anlaysis of Multiple Gene Expression

27 Feb 1998

Peter T. Nelson led this live discussion on 27 February 1998. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Paper Under Discussion: Cheetham JE, Coleman PD, Chow N. Isolation of Single ...

Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down's Syndrome Patients

28 May 1998

Chris Weihl led this live discussion on 28 May 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.    Article under discussion van Leeuwen FW, de Kleijn DPV, van den Hurk HH, Neubauer A, Sonnemans ...

Pin1, Tau and the Cell Cycle in Alzheimer Disease

03 Aug 1999

June Kinoshita, with Peter Davies, led this live discussion on 3 August 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.    Paper under discussion: Lu, Pei-Jung, Wulf, Gerburg, Zhou, Xiao Zhen, ...

Beta-Catenin and PS1

13 Aug 1999

Chris Weihl, with Bruce Yankner, Benjamin Wolozin, Eddie Koo, and Kenneth Kosik led this live discussion on 13 August 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion ...

Protofibrillar Aβ in Alzheimer's Disease

17 Feb 2000

Dennis Selkoe, Dean Hartley, and William Klein led this live discussion on 17 February 2000. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held Thursday, 17 February ...

Generation of an Apoptotic Intracellular Peptide by γ-secretase Cleavage of Alzheimer's β-amyloid Precursor Protein

20 Sep 2000

Benjamin Wolozin, with Luciano D'Adamio and Eddie Koo, led this live discussion on 20 September 2000. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.    Journal of Alzheimer's Disease. 2000 ...

New Theories of Presenilin Function

12 Dec 2000

Chris Weihl led this live discussion on 12 December 2000. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held on 12 December 2000 and moderated by Chris Weihl. ...

The Role of ApoE in Alzheimer's Disease: An Alternative View

11 Dec 2001

Keith Crutcher led this live discussion on 11 December 2001. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held on 11 December 2001. Participants: Keith Crutcher, Nico ...

Neural Stem Cells to the Rescue—Can Neuroreplacement Ever Become a Treatment for Alzheimer's?

09 Jul 2002

Kiminobu Sugaya led this live discussion on 9 July 2002. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held 9 July 2002, 12 noon-1 p.m EST with Kiminobu Sugaya. ...

Alzheimer Genes in Cortical Development: How Do Their Prenatal Functions Relate to Dementia?

12 Jul 2002

Jie Shen led this live discussion on 12 July 2002. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held 12 July 2002, 12 noon-1 p.m EST with Jie Shen. Participants: Jie ...

From Here to There: AβPP as an Axonal Transport Receptor—How Could This Explain Neurodegeneration in AD?

15 Jul 2002

Larry Goldstein led this live discussion on 15 July 2002. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.    See a follow-up live discussion background text: Axonal Transport Hypothesis Moves On to ...

Will Probing Flies and Worms Bear Fruit in the Search for New Genes Involved in Alzheimer's?

29 Oct 2002

Mel Feany led this live discussion on 29 October 2002. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held 29 October 2002, featuring Mel Feany of Brigham and Women' ...

CAA: We All Know It's There, But Just What Is It Doing in Alzheimer's?

12 Mar 2003

Steven Greenberg and Mathias Jucker led this live discussion on 12 March 2003. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript unavailable. Background Text By Steven Greenberg and Mathias ...

RNAi in Neurodegenerative Diseases—What's the Therapeutic Potential?

18 Mar 2003

By Zuoshang Xu, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 Zuoshang Xu led this live discussion on 18 March 2003. Readers are invited to submit additional comments by using our ...