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Webinar: Cortex Aging Too Fast? Blame TMEM106B and Progranulin

If age is the strongest risk factor for Alzheimer’s and other neurodegenerative diseases, how come some nonagenarians stay sharp while others lose their edge? Genetics beyond the known genes linked to pathologies, such as amyloid plaques and ...

What Price Privacy? Is the HIPAA Law Stifling Dementia Research?

Are you a dementia epidemiologist trying to access patient records so you can puzzle out disease associations? Are you a clinical investigator trying to recruit patients to a trial? Are you a professional dementia care provider trying desperately to spend ...

Weeding Mendel’s Garden: Can We Hoe Dubious Genetic Associations?

Scientists have uncovered hundreds of genetic variants that purportedly cause familial forms of various neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementias, and amyotrophic lateral sclerosis. But are all of these ...

Making a BioMark on Alzheimer Disease

Our thanks to Practical Neurology for granting permission to reprint the full text of a recent article (.pdf) by John Trojanowski. John Trojanowski, Les Shaw, and Anne Fagan led this live discussion on 1 June 2005. Readers are invited to submit additional ...

Fluid Business: Could “Liquid” Protein Herald Neurodegeneration?

Could the protein aggregates that cause neurodegeneration turn out to be the cellular equivalent of ice cubes? Scientists investigating how proteins naturally transition between gas-like solutions, condensed liquids, solidified gels, and insoluble fibrils ...

Webinar: O Blood-Based Biomarker, Where Art Thou?

Our Webinar on 17 June 2013 covered the latest research and future directions on blood-based biomarkers discussed at a recent Alzheimer’s Drug Discovery Foundation/Alzheimer’s Association conference. Sid O’Bryant, Texas Tech University, Lubbock; Samantha ...

Using ADNI Data—Online Training, Part 1

On 4 April 2013, the Alzheimer's Disease Neuroimaging Initiative biostatistics core held the first session of its two-part online training course on using ADNI data. Led by Danielle Harvey of the University of California, Davis, the session gave a ...

International Student Workshop on AD

What makes a good grant proposal in Alzheimer’s research? How to develop and present it? What are funders looking for? Students from all over the world learned the answers by working hands-on with established Alzheimer’s disease researchers at a workshop ...

Latest γ-Secretase Substrate Involved in Synaptic Stability, Autism?

Over the years, γ-secretase has garnered intense interest from scientists and drug developers who have targeted the multimeric complex in an attempt to curb production of amyloid-β (Aβ), the peptide believed to underlie Alzheimer’s disease. Meanwhile, the ...

Who Should Use the New Diagnostic Guidelines? The Debate Continues

Download a PDF of this Forum Discussion Ever since new criteria came out for a research diagnosis of prodromal/preclinical Alzheimer’s disease, plus criteria for a research and clinical diagnosis of the MCI and dementia stages of the disease, they have ...

Adding Dynamics and Nuance to Alzheimer’s Staging

Being able to image amyloid, glucose metabolism, atrophy, even network connectivity in living patients has been a boon for those trying to stage the progression of Alzheimer’s disease. Using magnetic resonance imaging (MRI) and positron emission ...

Evolution of AD Trials

In a sign that researchers are grappling with therapy development, the 4th International Conference on Clinical Trials on Alzheimer's Disease was filled beyond the capacity of its venue, drawing 522 researchers from around the globe. Held 3-5 ...

Slow Aβ Clearance Is ApoE4’s Modus Operandi in Late-Onset AD

Alzforum has been pleased to partner with the journal Science Translational Medicine in hosting a Webinar discussion of a new Alzheimer’s disease research study published 29 June 2011. The journal generously granted free access to Castellano et al. for ...

Intraneuronal Aβ: Was It APP All Along?

On 16 June 2011, ARF held a Webinar with Eddie Lee, Todd Golde, Gunnar Gouras, Frank LaFerla, Virginia Lee, Lars Nilsson, and Robert Vassar to discuss this study’s implications for intraneuronal Aβ and its role in AD pathogenesis. The Guest Moderator was ...

Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.

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