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Adding Dynamics and Nuance to Alzheimer’s Staging

Being able to image amyloid, glucose metabolism, atrophy, even network connectivity in living patients has been a boon for those trying to stage the progression of Alzheimer’s disease. Using magnetic resonance imaging (MRI) and positron emission ...

How Cognitive Stimulation Might Protect Against Aβ Oligomers

Cognitive stimulation has been shown to lower the risk of Alzheimer’s disease, but what actually happens in the brain to confer protection? In the March 6 Neuron, researchers led by Dennis Selkoe report that β2-adrenergic signaling plays a key role. Wild ...

Fluid Business: Could “Liquid” Protein Herald Neurodegeneration?

Could the protein aggregates that cause neurodegeneration turn out to be the cellular equivalent of ice cubes? Scientists investigating how proteins naturally transition between gas-like solutions, condensed liquids, solidified gels, and insoluble fibrils ...

The Alzheimer Biomarker Knowledge Base

Debra Revere discussed how the tools developed by the Telemakus Research Group have been used to extract research methods, animal models, data from tables and figures, and research results from published literature.   View Presentation You will need ...

Intraneuronal Aβ: Was It APP All Along?

On 16 June 2011, ARF held a Webinar with Eddie Lee, Todd Golde, Gunnar Gouras, Frank LaFerla, Virginia Lee, Lars Nilsson, and Robert Vassar to discuss this study’s implications for intraneuronal Aβ and its role in AD pathogenesis. The Guest Moderator was ...

Learn About AD Biomarker Meta-Analysis on AlzBiomarker Database

In the April 8 Lancet Neurology, researchers led by Bob Olsson at the University of Gothenburg, Sweden, reported the most comprehensive meta-analysis of published Alzheimer’s disease fluid biomarker data to date. The researchers scoured literature going ...

Webinar: Cortex Aging Too Fast? Blame TMEM106B and Progranulin

If age is the strongest risk factor for Alzheimer’s and other neurodegenerative diseases, how come some nonagenarians stay sharp while others lose their edge? Genetics beyond the known genes linked to pathologies, such as amyloid plaques and ...

Who Should Use the New Diagnostic Guidelines? The Debate Continues

Download a PDF of this Forum Discussion Ever since new criteria came out for a research diagnosis of prodromal/preclinical Alzheimer’s disease, plus criteria for a research and clinical diagnosis of the MCI and dementia stages of the disease, they have ...

What Price Privacy? Is the HIPAA Law Stifling Dementia Research?

Are you a dementia epidemiologist trying to access patient records so you can puzzle out disease associations? Are you a clinical investigator trying to recruit patients to a trial? Are you a professional dementia care provider trying desperately to spend ...

Updated Diagnostic Criteria and Management of Lewy Body Dementia

Despite being arguably the second most common dementing disorder, dementia with Lewy bodies, aka DLB, remains both mysterious and understudied.  On Tuesday, October 10, 2017, the Lewy Body Dementia Association and Alzforum co-hosted a webinar discussion ...

Weeding Mendel’s Garden: Can We Hoe Dubious Genetic Associations?

Scientists have uncovered hundreds of genetic variants that purportedly cause familial forms of various neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementias, and amyotrophic lateral sclerosis. But are all of these ...

Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.

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