Targeting Tumor Necrosis Factor—A Therapeutic Strategy for AD

• 2 Comments

29 May 2008

prevent TNFα transcription (25,26). A possible post-translational therapeutic target in AD is TACE (TNFα

Non-coding RNAs in Neurodegeneration

22 Oct 2007

Peter T. Nelson led this Webinar from 12:00-1:30 p.m. (U.S. Eastern Time) on Friday, 26 October

Susceptibility Testing and Risk Assessment in Alzheimer Disease

01 May 2007

Alzheimer Disease. Alzheimer's Disease and Associated Disorders, 2000. 14(3): p. 129-136. Abstract 26.

Presenilin Loss of Function—Plan B for AD?

• 21 Comments

09 Mar 2007

These are comfortable times for the amyloid hypothesis, it would seem. Every week brings more good news about some anti-amyloid intervention having “cured” mice from their “Alzheimer’s.” On the human front, we are eagerly awaiting such therapeutics to sho

The Functional Roles of APP Cytoplasmic Domain—Conflicts and Consensus

21 Dec 2006

2001 Dec 18;98(26):14979-84. Abstract 6. Hébert SS, Serneels L, Tolia A, Craessaerts K, Derks C,

Messing with the Membrane—An Alternative Interpretation of the Amyloid-β Hypothesis

• 20 Comments

01 Nov 2006

disease. Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9093-8. Copyright © 2005 National Academy of

Webinar: The NeuronDB Knowledge Base

17 Oct 2006

this Webinar on 26 October 2006. Readers are invited to submit additional comments by using our

Cell Cycle Hypothesis Pedaling into Mainstream Acceptance? Results in Fly, Mouse Models Warrant a Second Look

• 4 Comments

12 Apr 2006

Vikram Khurana, Karl Herrup, Bruce Lamb, Inez Vincent, Rachael Neve, Donna McPhie, Dan Geschwind, Cathy Andorfer, and Xiongwei Zhu participated in a discussion of how far the cell cycle hypothesis has come in the past few years, and where to go next. Vik

Gain or Loss of Function—Time to Shake up Assumptions on γ-Secretase in Alzheimer Disease?

• 23 Comments

25 Mar 2006

We invite you to participate in this “offline” Forum discussion with past ARF advisors Peter Davies of Albert Einstein College of Medicine in the Bronx, New York, and Bart De Strooper at K.U. Leuven, Belgium. The goal of this discussion is to explore the

The Pathogen Hypothesis—Challenging the Primacy of Genetics in Late-Onset Alzheimer Disease.

• 5 Comments

22 Jan 2006

We invite you to participate in this "offline" Forum Discussion led by Brian Balin (Philadelphia College of Osteopathic Medicine). This discussion will extend our previously held live discussion on the Pathogen Hypothesis of Alzheimer Disease. T

Are Glia Active Participants in Neurodegenerative Disease?

• 1 Comment

05 Dec 2005

Ben Barres led the first in a series of Alzforum discussions about the role of glial cells in Alzheimer’s and other neurodegenerative diseases. It has become trendy to say that glia are more than just glue, but in reality, science has not yet advanced sig

Ceramide and Cholesterol: Possible Connections Between Normal Aging of the Brain and Alzheimer’s Disease

15 Oct 2005

a long-chain (C26) ceramide synthase. A human homolog of LAG1 can correct the phenotype in yeast, so we do have

Now You See Them, Now You Don't: The Amyloid Channel Hypothesis

16 Jun 2005

Ever since amyloid-β (Aβ) was identified as the major component in amyloid plaques, scientists have been trying to decipher just exactly what the little peptide does. Most researchers would agree that Aβ is toxic to cells, but some are still skeptical. Ev

Caloric Restriction: Eat Less, Live Longer!

• 4 Comments

31 Mar 2005

Neurosci. 2003;26:81-104. Epub 2003 Jan 24. Review. Abstract Reiss AB, Siller KA, Rahman MM, Chan ES, Ghiso

Cell Death: Time to Push It Out of the Doldrums

• 10 Comments

10 Sep 2004

system neurotoxins. Proc Natl Acad Sci U S A. 1998 May 26 ; 95(11):6448-53. Lang-Rollin IC, Rideout HJ,