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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
DAYVIGO Lemborexant,
E2006
Alzheimer's Disease (Phase 2) Eisai Co., Ltd. Other Small Molecule Insomnia
ABT 418 Alzheimer's Disease (Discontinued) Cholinergic System Small Molecule None
ABT-089 Alzheimer's Disease (Discontinued) Abbott Laboratories Cholinergic System Small Molecule
ABT-288 Alzheimer's Disease (Discontinued) AbbVie Cholinergic System, Other Neurotransmitters Small Molecule
ABT-384 Alzheimer's Disease (Discontinued) AbbVie Other Small Molecule
ABT-957 Alzheimer's Disease (Phase 1) AbbVie Other Small Molecule
AF 102B cevimeline HCL,
Evoxac™
Alzheimer's Disease (Discontinued) SnowBrand Pharmaceuticals, Inc. Cholinergic System Small Molecule Treatment of dry mouth in Sjogren's syndrome.
AGB101 levetiracetam MCI-AD (Phase 3) AgeneBio, Inc. Amyloid-Related Small Molecule
ALZ-801 NRM-8499, homotaurine, 3-APS Alzheimer's Disease (Phase 1) Alzheon Inc. Amyloid-Related Small Molecule
ALZT-OP1 Cromolyn sodium, Intal,
Ibuprofen
Alzheimer's Disease (Phase 3) AZTherapies, Inc. Amyloid-Related, Inflammation Combination, Small Molecule
AMX0035 Amyotrophic Lateral Sclerosis (Phase 2), Alzheimer's Disease (Phase 2) Amylyx Pharmaceuticals Inc Other Combination, Small Molecule
ASN120290 ASN-561 Progressive Supranuclear Palsy (Phase 1) Asceneuron SA Tau Small Molecule
AVP-786 Alzheimer's Disease (Phase 3), Schizophrenia (Phase 2) Avanir Pharmaceuticals, Concert Pharmaceuticals, Inc., Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Combination, Small Molecule
AVP-923 Nuedexta,
Zenvia
Alzheimer's Disease (Phase 4), Amyotrophic Lateral Sclerosis (Phase 3), Parkinson's Disease (Phase 3) Avanir Pharmaceuticals, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Combination, Small Molecule
AXS-05 Dextromethorphan/bupropion Alzheimer's Disease (Phase 2/3) Axsome Therapeutics, Inc. Other Neurotransmitters Combination, Small Molecule
AZD1446 TC-6683 Alzheimer's Disease (Discontinued) AstraZeneca, Targacept Cholinergic System Small Molecule None
AZD3480 ispronicline,
TC-1734
Alzheimer's Disease (Inactive) AstraZeneca, Targacept Cholinergic System Small Molecule
AZP2006 AZP-2006 Progressive Supranuclear Palsy (Phase 2), Alzheimer's Disease (Phase 1) AlzProtect Tau, Inflammation, Other Small Molecule
Acitretin Soriatane ,
Neotigason,
RO 101670
Alzheimer's Disease (Phase 2) Actavis, Allergan plc Amyloid-Related Small Molecule Psoriasis in US
Allopregnanolone brexanolone,
3α-hydroxy-5α-pregnan-20-one,
3α,5α-tetrahydroprogesterone
Alzheimer's Disease (Phase 1) Other Neurotransmitters, Other Small Molecule
Ambroxol Ambrosan, Mucosolvan Parkinson's Disease (Phase 2), Parkinson's Disease Dementia (Phase 2) alpha-synuclein, Other Small Molecule
Anle138b Multiple System Atrophy (Phase 1) Tau, alpha-synuclein, Other Small Molecule
Apabetalone RVX208,
RVX000222
MCI-VaD (Phase 3) Resverlogix Corporation Other Small Molecule
Aripiprazole Abilify,
BMS-337039
Alzheimer's Disease (Phase 3), Schizophrenia (Approved) Bristol-Myers Squibb, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
Atabecestat JNJ-54861911 ,
BACE inhibitor
Alzheimer's Disease (Discontinued) Janssen, Shionogi Pharma Amyloid-Related Small Molecule
Atomoxetine ATX,
Strattera
Alzheimer's Disease (Discontinued) Eli Lilly & Co. Other Neurotransmitters Small Molecule ADHD in US
Atorvastatin Lipitor™ ,
Zarator®,
Sortis®,
Tahor®
Alzheimer's Disease (Inactive) Pfizer Cholesterol Small Molecule Hypercholesterolaemia
Avagacestat BMS-708163 Alzheimer's Disease (Discontinued) Bristol-Myers Squibb Amyloid-Related Small Molecule
Azeliragon PF-04494700,
TTP488
Alzheimer's Disease (Phase 2/3) Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC Amyloid-Related, Inflammation Small Molecule
BI 1181181 VTP 37948,
BACE inhibitor
Alzheimer's Disease (Discontinued) Boehringer Ingelheim, Vitae Pharmaceuticals Amyloid-Related Small Molecule
BI 409306 SUB 166499 Alzheimer's Disease (Discontinued), Schizophrenia (Phase 2) Boehringer Ingelheim Other Neurotransmitters, Other Small Molecule
BI 425809 Alzheimer's Disease (Discontinued), Schizophrenia (Phase 2) Boehringer Ingelheim Other Neurotransmitters Small Molecule
BPN14770 Alzheimer's Disease (Phase 2) Shionogi Pharma, Tetra Therapeutics Cholinergic System, Other Small Molecule
Besipirdine HCl HP 749 Alzheimer's Disease (Discontinued) Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule
Bexarotene Targretin® Alzheimer's Disease (Phase 2) Ligand Pharmaceuticals, Inc., ReXceptor Inc. Amyloid-Related, Unknown Small Molecule Cutaneous T-cell Lymphoma in US
Blarcamesine Anavex 2-73 Alzheimer's Disease (Phase 2), Parkinson's Disease Dementia (Phase 2) Anavex Life Science Corp. Other Small Molecule
Bosutinib BOSULIF®,
PF-5208763,
SKI-606
Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) Pfizer Other Small Molecule Chronic myeloid leukemia
Brexpiprazole Rexulti,
OPC 34712
Alzheimer's Disease (Phase 3), Schizophrenia (Approved) H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
CHF 5074 Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. Amyloid-Related, Inflammation, Other Small Molecule
COR388 Alzheimer's Disease (Phase 1) Cortexyme, Inc. Other Small Molecule
CVN424 Parkinson's Disease (Phase 2) Cerevance Other Neurotransmitters Small Molecule
CX516 Ampalex Alzheimer's Disease (Discontinued) Cortex Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule None
Carvedilol Coreg,
Artist ,
Aucardic,
Dilatrend,
Kredex
Alzheimer's Disease (Phase 4) Procter & Gamble Unknown Small Molecule Hypertension, heart failure, angina pectoris
Celecoxib Celebrex Alzheimer's Disease (Discontinued) Pfizer Inflammation Small Molecule Pain, Arthritis
Circadin Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Small Molecule Insomnia
Citalopram escitalopram,
Celexa,
Lexapro ,
Cipralex
Alzheimer's Disease (Phase 3), Preclinical Alzheimer's Disease (Phase 1) Other Neurotransmitters Small Molecule Depression, generalized anxiety disorder
Clioquinol iodochlorhydroxyquin,
PBT-1
Alzheimer's Disease (Discontinued) Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule
DNL151 Parkinson's Disease (Phase 1) Denali Therapeutics Inc. Inflammation, Other Small Molecule
DNL201 Parkinson's Disease (Phase 1) Denali Therapeutics Inc. Inflammation, Other Small Molecule
DNL747 SAR 443060 Alzheimer's Disease (Inactive), Amyotrophic Lateral Sclerosis (Inactive) Denali Therapeutics Inc., Sanofi Inflammation Small Molecule
Dapagliflozin Farxiga,
Forxiga,
BMS 512148
Alzheimer's Disease (Phase 1/2) AstraZeneca, Bristol-Myers Squibb Other Small Molecule
Dapsone Avlosulfon,
Diaminodiphenylsulfone,
DDS
Alzheimer's Disease (Inactive) Immune Network Ltd. Other Small Molecule Leprosy, malaria, some bacterial skin infections
Dexpramipexole R-pramipexole,
RPPX,
KNS-760704 ,
BIIB 050
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) Biogen, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule
Dimebon Dimebolin,
Latrepirdine,
Pf-01913539
Alzheimer's Disease (Discontinued), Huntington's Disease (Discontinued) Medivation, Inc. Other Neurotransmitters, Unknown Small Molecule Anti-histamine use in Russia
Donepezil Aricept™,
Donepezil hydrochloride,
Eranz®,
E 2020
Alzheimer's Disease (Approved), Dementia with Lewy Bodies (Phase 3), Down's Syndrome (Phase 2), Parkinson's Disease Dementia (Phase 3) Eisai Co., Ltd., Pfizer Cholinergic System Small Molecule Alzheimer's Disease
EHT 0202 Etazolate Alzheimer's Disease (Phase 2) ExonHit Therapeutics Other Small Molecule None
ELND005 AZD-103,
Scyllo-inositol,
cyclohexane-1,2,3,4,5,6-hexol
Alzheimer's Disease (Inactive) Elan Corporation, Opko Health, Speranza Therapeutics, Transition Therapeutics, Inc. Amyloid-Related Small Molecule None
EVP-0962 EVP 0015962 Alzheimer's Disease (Phase 2), Mild Cognitive Impairment (Phase 2) FORUM Pharmaceuticals Inc. Amyloid-Related Small Molecule
Edonerpic T-817 MA, T 817 Alzheimer's Disease (Inactive) Toyama Chemical Co., Ltd. Other, Unknown Small Molecule
Elayta CT1812 Alzheimer's Disease (Phase 2) Cognition Therapeutics Inc. Amyloid-Related Small Molecule
Elenbecestat E2609,
BACE inhibitor
Alzheimer's Disease (Discontinued) Biogen, Eisai Co., Ltd. Amyloid-Related Small Molecule
Empagliflozin Jardiance,
BI-10773
Alzheimer's Disease (Phase 1) Boehringer Ingelheim, Eli Lilly & Co. Other Small Molecule Type 2 Diabetes, Cardiovascular disease
Encenicline EVP-6124 ,
MT-4666,
α7-nAChR agonist
Alzheimer's Disease (Discontinued), Schizophrenia (Discontinued) FORUM Pharmaceuticals Inc., Mitsubishi Tanabe Pharma Cholinergic System Small Molecule None
Epothilone D BMS-241027 Alzheimer's Disease (Discontinued) Bristol-Myers Squibb Tau Small Molecule
Eptastigmine MF 201 Alzheimer's Disease (Discontinued) Mediolanum Cholinergic System Small Molecule None
Exendin-4 Exenatide,
Byetta,
Bydureon
Alzheimer's Disease (Inactive), Parkinson's Disease (Phase 3) Other Small Molecule Diabetes mellitus in US
FRM-0334 EVP-0334 Frontotemporal Dementia (Phase 2) FORUM Pharmaceuticals Inc. Other Small Molecule
Flurizan™ tarenflurbil ,
r-flurbiprofen,
MPC-7869
Alzheimer's Disease (Discontinued) Myriad Genetics & Laboratories Amyloid-Related Small Molecule None
G-CSF Filgrastim Alzheimer's Disease (Phase 2) Other Small Molecule Neutropenia in US
GC 021109 Alzheimer's Disease (Phase 1) GliaCure Inflammation Small Molecule
GLN-1062 Memogain Alzheimer's Disease (Phase 1) Galantos Pharma, Neurodyn Cholinergic System Small Molecule
GSK239512 Alzheimer's Disease (Discontinued) GlaxoSmithKline (GSK) Cholinergic System, Other Neurotransmitters Small Molecule
GSK2647544 GSK-2647544 Alzheimer's Disease (Phase 1) GlaxoSmithKline (GSK) Cholesterol Small Molecule
GV-971 sodium oligomannate,
sodium oligo-mannurarate
Alzheimer's Disease (Phase 3) Shanghai Green Valley Pharmaceuticals Amyloid-Related, Inflammation Small Molecule
Galantamine Razadyne™,
Reminyl™,
Nivalin®
Alzheimer's Disease (Approved) Janssen, Ortho-McNeil Pharmaceutical, Sanochemia Pharmazeutika, Shire, Takeda Pharmaceutical Company Cholinergic System Small Molecule Mild to Moderate Alzheimer's disease
Gemfibrozil Lopid,
Jezil,
Gen-Fibro
Alzheimer's Disease (Phase 1) Cholesterol Small Molecule Hyperlipidemia
Guanfacine Intuniv,
SPD503,
Afken,
Estulic,
Tenex
Alzheimer's Disease (Phase 3) Other Neurotransmitters Small Molecule Attention-deficit hyperactivity disorder, hypertension
HF0220 Alzheimer's Disease (Discontinued) Newron Inflammation Small Molecule
HTL0018318 Alzheimer's Disease (Phase 1), Dementia with Lewy Bodies (Phase 2) Allergan plc, Sosei Heptares Cholinergic System Small Molecule
Huperzine A ZT-1,
DEBIO 9902 ,
Qian ceng ta,
Cerebra capsule,
Pharmassure Memorall capsule
Alzheimer's Disease (Inactive) Debiopharm Group™, Neuro-Hitech, Inc. Cholinergic System Small Molecule, Supplement, Dietary None
Ibuprofen Advil™,
Nuprin™ ,
Motrin™
Alzheimer's Disease (Discontinued) Amyloid-Related, Inflammation Small Molecule Pain and Fever
Idalopirdine Lu AE58054,
SGS 518
Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
Idebenone Catena,
Sovrima
Alzheimer's Disease (Discontinued) Takeda Pharmaceutical Company Other Small Molecule None
Intepirdine RVT-101,
SB 742457 ,
GSK 742457
Alzheimer's Disease (Discontinued), Dementia with Lewy Bodies (Discontinued) Axovant Sciences Ltd. Other Neurotransmitters Small Molecule
Inzomelid Alzheimer's Disease (Phase 1), Parkinson's Disease (Phase 1) Inflazome Ltd. Inflammation Small Molecule
JNJ-40346527 Edicotinib,
JNJ-527,
PRV-6527
Alzheimer's Disease (Phase 1) Janssen Inflammation Small Molecule
Kynmobi APL-130277,
apomorphine hydrochloride sublingual thin film
Parkinson's Disease (Approved) Sunovion Pharmaceuticals Inc. Other Neurotransmitters Small Molecule
LM11A-31-BHS LM11A-31 Alzheimer's Disease (Phase 2) PharmatrophiX Other Small Molecule
LMTM TRx0237, LMT-X,
Methylene Blue,
Tau aggregation inhibitor (TAI)
Alzheimer's Disease (Phase 3), Frontotemporal Dementia (Phase 3) TauRx Therapeutics Ltd Tau Small Molecule Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
LTI-291 Parkinson's Disease (Phase 2) Lysosomal Therapeutics Inc. Other Small Molecule
LU25-109 Alzheimer's Disease (Discontinued) Cholinergic System Small Molecule None
LY2886721 BACE inhibitor Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule
LY3202626 BACE Inhibitor Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule
Ladostigil Ladostigil hemitartrate,
TV3326
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Discontinued) Avraham Pharmaceuticals Ltd Cholinergic System Small Molecule
Lanabecestat AZD3293 ,
LY3314814,
BACE inhibitor
Alzheimer's Disease (Discontinued) AstraZeneca, Eli Lilly & Co. Amyloid-Related Small Molecule
Levetiracetam Keppra Alzheimer's Disease (Phase 3), Parkinson's Disease (Discontinued) UCB S.A. Amyloid-Related, Other Small Molecule Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries
Linopirdine DuP996 Alzheimer's Disease (Discontinued) Other Small Molecule None
Lornoxicam Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) JSW Lifesciences Inflammation Small Molecule Pain in US
Lumateperone ITI-007 Alzheimer's Disease (Phase 3), Schizophrenia (Phase 3), Bipolar Disorder (Phase 3) Bristol-Myers Squibb, Intra-Cellular Therapies, Inc. Other Neurotransmitters Small Molecule
MEM 1003 BAY Z 4406 Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued), Vascular Dementia (Discontinued), Bipolar Disorder (Discontinued) Memory Pharmaceuticals Corporation Other Small Molecule None
MK-7622 Alzheimer's Disease (Discontinued) Merck Unknown Small Molecule
MKC-231 Alzheimer's Disease (Inactive) Mitsubishi Tanabe Pharma Unknown Small Molecule None
MSDC-0160 Mitoglitazone Alzheimer's Disease (Phase 2) Metabolic Solutions Development Company Other Small Molecule
MW151 MW01-2-151SRM,
Minozac,
MW01-2-151WH,
compound 17
Alzheimer's Disease (Phase 1) ImmunoChem Therapeutics, LLC Inflammation Small Molecule
Masitinib Masivet,
Kinavet,
AB1010,
Masitinib mesylate
Alzheimer's Disease (Phase 3), Amyotrophic Lateral Sclerosis (Phase 3) AB Science Other Small Molecule
Masupirdine SUVN-502 Alzheimer's Disease (Phase 2) Suven Life Sciences Ltd Other Neurotransmitters Small Molecule
Memantine Ebixa™,
Namenda™ ,
Axura®,
Akatinol®,
Memary®
Alzheimer's Disease (Approved) Forest Laboratories, Inc., H. Lundbeck, Merz Pharma Other Neurotransmitters Small Molecule Alzheimer's Disease
Metformin Glucophage,
Glucophage XR
Alzheimer's Disease (Phase 2/3) Other Small Molecule Type 2 Diabetes
Methylphenidate Ritalin, Concerta Alzheimer's Disease (Phase 4) Other Neurotransmitters Small Molecule Attention-deficit hyperactivity disorder (ADHD), narcolepsy
Metrifonate trichlorfon Alzheimer's Disease (Discontinued) Cholinergic System Small Molecule None
Milameline CI 979 Alzheimer's Disease (Discontinued) Aventis Pharmaceuticals, Inc. (was Hoechst) Cholinergic System Small Molecule None
Minocycline Solodyn,
Arestin,
Minocin,
Dynacin
Alzheimer's Disease (Discontinued) Other Small Molecule
Montelukast Singulair, MK0476 Alzheimer's Disease (Phase 2) Intelgenx Inflammation Small Molecule Asthma
NDX-1017 Alzheimer's Disease (Phase 1) Athira Pharma Other Small Molecule
NGX267 AF267B Alzheimer's Disease (Inactive) TorreyPines Therapeutics, Inc. Cholinergic System Small Molecule None
NIC5-15 Pinitol,
D-Pinitol
Alzheimer's Disease (Phase 2) Humanetics Pharmaceuticals Corporation Amyloid-Related, Other Small Molecule, Supplement, Dietary
NPT520-34 Amyotrophic Lateral Sclerosis (Phase 1), Parkinson's Disease (Phase 1) Neuropore Therapies, Inc. alpha-synuclein, Inflammation, Other Small Molecule
NS2330 Tesofensine Alzheimer's Disease (Discontinued) NeuroSearch A/S Other Neurotransmitters Small Molecule
Naproxen Aleve™,
Anaprox™,
Naprosyn™
Alzheimer's Disease (Discontinued) Procter & Gamble Inflammation Small Molecule Over-the-counter drug for reduction of pain, fever, inflammation, and stiffness.
Nasal Insulin Detemir,
Levemir,
Humulin,
Novolin
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) Amyloid-Related, Other Small Molecule, Other Diabetes
Nefiracetam Alzheimer's Disease (Discontinued) Daiichi Sankyo Pharmaceuticals Cholinergic System Small Molecule None
Neflamapimod VX-745 Alzheimer's Disease (Phase 2) EIP Pharma, LLC Inflammation Small Molecule
Nelonicline ABT-126 Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) AbbVie Cholinergic System Small Molecule
Nelotanserin APD-125 Dementia with Lewy Bodies (Discontinued) Axovant Sciences Ltd. Other Neurotransmitters Small Molecule
NeoTrofin AIT-082,
leteprinim
Alzheimer's Disease (Discontinued) NeoTherapeutics, Inc. Unknown Small Molecule None
Neramexane MRZ 2/579 Alzheimer's Disease (Discontinued) Forest Laboratories, Inc., Merck Other Neurotransmitters Small Molecule None
Nicotinamide Enduramide,
Niacinamide,
Nicotinic acid amide,
Vitamin B3
Alzheimer's Disease (Phase 2) Other Small Molecule
Nilotinib Tasigna,
AMN107
Parkinson's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Alzheimer's Disease (Phase 2) Novartis Pharmaceuticals Corporation Other Small Molecule Chronic myeloid leukemia
Nilvadipine Nilvad,
Nivadil,
ARC029
Alzheimer's Disease (Inactive) Archer Pharmaceuticals, Inc. Other Small Molecule
Nimodipine Nimotop Frontotemporal Dementia (Phase 1) Bayer Metals Small Molecule Subarachnoid hemorrhage
ORM-12741 Alzheimer's Disease (Phase 2) Orion Pharma Other Neurotransmitters Small Molecule
PBT2 PBT-2 Alzheimer's Disease (Phase 2), Huntington's Disease (Phase 2) Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule
PF-05212377 PF-5212377,
WYE-103760,
SAM-760
Alzheimer's Disease (Discontinued) Pfizer Other Neurotransmitters Small Molecule
PF-05251749 Alzheimer's Disease (Discontinued) Pfizer Other Small Molecule
PF-06648671 Alzheimer's Disease (Discontinued) Pfizer Amyloid-Related Small Molecule
PF-06751979 BACE inhibitor Alzheimer's Disease (Discontinued) Pfizer Amyloid-Related Small Molecule
PF-06852231 Alzheimer's Disease (Discontinued) Pfizer Cholinergic System Small Molecule
PQ912 Alzheimer's Disease (Phase 2) Probiodrug AG, Vivoryon Therapeutics AG Amyloid-Related, Inflammation Small Molecule
PRX-03140 Potassium salt Alzheimer's Disease (Inactive) Epix Pharmaceuticals Other Small Molecule
PTI-125 Alzheimer's Disease (Phase 2) Cassava Sciences Amyloid-Related Small Molecule
PU-AD Alzheimer's Disease (Phase 1) Samus Therapeutics Other Small Molecule
PXT864 PXT00864 Alzheimer's Disease (Phase 2) Pharnext Other Neurotransmitters Combination, Small Molecule
Phenserine Alzheimer's Disease (Inactive) Annovis Bio, TorreyPines Therapeutics, Inc. Cholinergic System Small Molecule
Physostigmine Salicylate Synapton Alzheimer's Disease (Discontinued) Forest Laboratories, Inc. Cholinergic System Small Molecule
Pimavanserin Nuplazid,
ACP-103,
Pimavanserin tartrate
Alzheimer's Disease (Phase 3), Schizophrenia (Phase 3), Dementia (Phase 3), Depression (Phase 3) Acadia Pharmaceuticals Other Neurotransmitters Small Molecule Parkinson's psychosis
Pioglitazone AD4833,
Actos®,
Glustin™,
Piozone®
Mild Cognitive Impairment (Phase 3) Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. Inflammation, Other Small Molecule Type 2 diabetes mellitus
Piromelatine Neu-P11 Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Neurotransmitters, Other Small Molecule
Posiphen ANVS-401,
(+)-phenserine,
Posiphen tartrate
Alzheimer's Disease (Phase 2) Annovis Bio Amyloid-Related, alpha-synuclein Small Molecule
Prazosin Prazosin hydrochloride,
Minipress,
Hypovase,
Vasoflex
Alzheimer's Disease (Phase 4) Other Neurotransmitters Small Molecule Hypertension
Prednisone Alzheimer's Disease (Discontinued) Inflammation Small Molecule
Propentofylline HWA 285,
PPF
Alzheimer's Disease (Discontinued) Unknown Small Molecule
RG3487 RO5313534,
MEM 3454
Alzheimer's Disease (Inactive) Roche Cholinergic System Small Molecule
RG7129 RO5508887,
BACE Inhibitor
Alzheimer's Disease (Discontinued) Roche Amyloid-Related Small Molecule
Rasagiline Rasagiline mesylate,
Azilect,
TVP-1012
Alzheimer's Disease (Phase 2), Parkinson's Disease (Approved), Amyotrophic Lateral Sclerosis (Inactive) Teva Other Neurotransmitters Small Molecule
Rember TM Methylene Blue ,
methylthioninium (MT),
TRx-0014,
Tau aggregation inhibitor (TAI)
Alzheimer's Disease (Discontinued) TauRx Therapeutics Ltd Tau Small Molecule Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
Resveratrol trans-3,4',5-trihydroxystilbene Alzheimer's Disease (Phase 3), Mild Cognitive Impairment (Phase 4) Other Small Molecule, Supplement, Dietary
Rilapladib SB-659032 Alzheimer's Disease (Phase 2) GlaxoSmithKline (GSK) Other Small Molecule
Riluzole Rilutek®,
RP 54274
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule Amyotrophic Lateral Sclerosis in many countries
Rivastigmine Exelon™,
Rivastigmine tartrate ,
Rivastach® Patch,
Prometax®,
SDZ ENA 713
Alzheimer's Disease (Approved), Parkinson's Disease Dementia (Approved) Novartis Pharmaceuticals Corporation Cholinergic System Small Molecule Mild to moderate Alzheimer’s disease and mild to moderate dementia related to Parkinson's disease
Rofecoxib Vioxx™ Alzheimer's Disease (Discontinued) Merck Inflammation Small Molecule Withdrawn from market
Rosiglitazone Rosiglitazone maleate,
Avandia
Alzheimer's Disease (Discontinued) GlaxoSmithKline (GSK) Other Small Molecule
Rotigotine Neupro Alzheimer's Disease (Phase 2) UCB S.A. Other Neurotransmitters Small Molecule Parkinson's disease, Restless Leg Syndrome
S 38093 Alzheimer's Disease (Discontinued) Servier Cholinergic System, Other Neurotransmitters Small Molecule
S-Equol Aus-131 Alzheimer's Disease (Phase 1) Ausio Pharmaceuticals, LLC Other Small Molecule
S47445 CX1632 Alzheimer's Disease (Discontinued) Cortex Pharmaceuticals, Inc., Servier Other Neurotransmitters Small Molecule
SAR110894D Alzheimer's Disease (Phase 2) Sanofi Other Small Molecule
SB 202026 Memric Alzheimer's Disease (Discontinued) Other Neurotransmitters Small Molecule
SGS-742 CGP-36742,
DVD-742
Alzheimer's Disease (Discontinued) Novartis Pharmaceuticals Corporation, Saegis Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule
ST101 ZSET1446 Alzheimer's Disease (Inactive) Sonexa Therapeutics, Inc. Unknown Small Molecule
SUVN-G3031 Alzheimer's Disease (Phase 1) Suven Life Sciences Ltd Cholinergic System, Other Neurotransmitters Small Molecule
Sabeluzole R58735 Alzheimer's Disease (Inactive) Unknown Small Molecule
Saracatinib AZD0530 Alzheimer's Disease (Discontinued), Parkinson's Disease (Phase 1) AstraZeneca Other Small Molecule
Semagacestat LY450139 Dihydrate ,
hydroxylvaleryl monobenzocaprolactam
Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule None
Sembragiline RO4602522,
RG1577
Alzheimer's Disease (Discontinued) Evotech AG Other Neurotransmitters, Other Small Molecule
Simvastatin Zocor®,
Lipex®,
Lipovas®,
Denan®
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Phase 4) Merck Cholesterol Small Molecule Hypercholesterolemia and diabetic cardiomyopathy.
Suritozole MD 26479 Alzheimer's Disease (Discontinued) Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule
Suvorexant Belsomra,
MK-4305
Alzheimer's Disease (Approved) Merck Other Small Molecule Insomnia, Insomnia in mild to moderate Alzheimer's disease
T3D-959 DB959 Alzheimer's Disease (Phase 2) T3D Therapeutics, Inc. Other Small Molecule
TPI 287 Alzheimer's Disease (Inactive), Corticobasal Degeneration (Inactive), Progressive Supranuclear Palsy (Phase 1) Cortice Biosciences Tau Small Molecule
Tacrine Cognex™ Alzheimer's Disease (Approved) Pfizer, Shionogi Pharma Cholinergic System Small Molecule
Telmisartan Micardis Alzheimer's Disease (Phase 2) Boehringer Ingelheim Other Small Molecule Hypertension
Thalidomide Thalomid® Alzheimer's Disease (Phase 2/3) Celgene Corporation Amyloid-Related, Inflammation Small Molecule
Tideglusib NP031112,
Nypta® ,
Zentylor™ ,
Glycogen synthase kinase 3 inhibitor,
NP12
Alzheimer's Disease (Discontinued), Progressive Supranuclear Palsy (Discontinued) Zeltia Group Tau Small Molecule
Umibecestat CNP520,
BACE Inhibitor
Alzheimer's Disease (Phase 2/3) Amgen, Inc., Novartis Pharmaceuticals Corporation Amyloid-Related Small Molecule
Vafidemstat ORY-2001 Alzheimer's Disease (Phase 2) Oryzon Corporate Other Neurotransmitters Small Molecule
Valacyclovir Valtrex,
Valaciclovir,
256U87
Alzheimer's Disease (Phase 2) GlaxoSmithKline (GSK) Other Small Molecule Herpes virus outbreaks
Valproate Depakote,
Depakene,
Valproic acid ,
Divalproex sodium
Alzheimer's Disease (Inactive) Abbott Laboratories Other Neurotransmitters Small Molecule Epilepsy, Bipolar disorder, Migraine
Varenicline Champix™,
Chantix™,
Varenicline tartrate,
CP-526,555,
Alpha4 beta2 nicotinic receptor agonist
Alzheimer's Disease (Discontinued) Pfizer Cholinergic System Small Molecule Smoking cessation
Vascepa Icosapent ethyl (IPE),
Ethyl eicosapentaenoic acid (E-EPA),
AMR101,
Miraxion
Alzheimer's Disease (Phase 2/3) Other Small Molecule Severe hypertriglyceridemia, and to lower risk of cardiovascular events in people with elevated triglycerides
Venglustat Ibiglustat,
GZ/SAR402671
Parkinson's Disease (Phase 2) Genzyme, Sanofi alpha-synuclein, Other Small Molecule
Verubecestat MK-8931, MK-8931-009 ,
BACE inhibitor
Alzheimer's Disease (Discontinued) Merck Amyloid-Related Small Molecule
Xaliproden SR 57746A Alzheimer's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule
Xanamem UE 2343 Alzheimer's Disease (Phase 2) Actinogen Medical Other Small Molecule