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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
Zagotenemab LY3303560 Alzheimer's Disease (Phase 2) Eli Lilly & Co. Tau, Unknown Immunotherapy (passive)
AADvac1 Axon peptide 108 conjugated to KLH Alzheimer's Disease (Phase 2), Progressive Nonfluent Aphasia (Phase 1) Axon Neuroscience SE Tau Immunotherapy (active)
ACI-35 Alzheimer's Disease (Phase 1) AC Immune SA, Janssen Tau Immunotherapy (active)
BIIB076 NI-105,
6C5 huIgG1/l
Alzheimer's Disease (Phase 1) Biogen, Neurimmune Tau Immunotherapy (passive)
BIIB080 IONIS-MAPTRx,
ISIS 814907
Alzheimer's Disease (Phase 1) Biogen, IONIS Pharmaceuticals Tau RNA-based
C2N 8E12 ABBV-8E12 Progressive Supranuclear Palsy (Phase 2), Alzheimer's Disease (Phase 2) AbbVie, C2N Diagnostics, LLC Tau Immunotherapy (passive)
Davunetide NAP,
AL-108
Mild Cognitive Impairment (Discontinued), Progressive Supranuclear Palsy (Discontinued), Schizophrenia (Discontinued), Frontotemporal Dementia (Inactive) Allon Therapeutics Inc., Paladin Labs Inc. Tau Other
Epothilone D BMS-241027 Alzheimer's Disease (Discontinued) Bristol-Myers Squibb Tau Small Molecule
Gosuranemab BIIB092,
BMS-986168, IPN007
Progressive Supranuclear Palsy (Phase 2), Alzheimer's Disease (Phase 2) Biogen, Bristol-Myers Squibb Tau Immunotherapy (passive)
JNJ-63733657 Mild AD (Phase 1) Janssen Tau Immunotherapy (passive)
LMTM TRx0237, LMT-X,
Methylene Blue,
Tau aggregation inhibitor (TAI)
Alzheimer's Disease (Phase 3), Frontotemporal Dementia (Phase 3) TauRx Therapeutics Ltd Tau Small Molecule Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
RG7345 RO6926496 Alzheimer's Disease (Discontinued) Tau Immunotherapy (passive)
Rember TM Methylene Blue ,
methylthioninium (MT),
TRx-0014,
Tau aggregation inhibitor (TAI)
Alzheimer's Disease (Discontinued) TauRx Therapeutics Ltd Tau Small Molecule Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
Semorinemab RO7105705, MTAU9937A,
RG6100
Alzheimer's Disease (Phase 2) AC Immune SA, Genentech, Hoffmann-La Roche Tau Immunotherapy (passive)
TPI 287 Alzheimer's Disease (Inactive), Corticobasal Degeneration (Inactive), Progressive Supranuclear Palsy (Phase 1) Cortice Biosciences Tau Small Molecule
Tideglusib NP031112,
Nypta® ,
Zentylor™ ,
Glycogen synthase kinase 3 inhibitor,
NP12
Alzheimer's Disease (Discontinued), Progressive Supranuclear Palsy (Discontinued) Zeltia Group Tau Small Molecule
UCB0107 UCB 0107 Progressive Supranuclear Palsy (Phase 1) UCB S.A. Tau Immunotherapy (passive)