Therapeutics
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| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
|---|---|---|---|---|---|---|
| ABT-384 | Alzheimer's Disease (Discontinued) | AbbVie | Other | Small Molecule | ||
| ABT-957 | Alzheimer's Disease (Phase 1) | AbbVie | Other | Small Molecule | ||
| AL001 | Frontotemporal Dementia (Phase 3) | Alector | Other | Immunotherapy (passive) | ||
| AMX0035 | Amyotrophic Lateral Sclerosis (Phase 2), Alzheimer's Disease (Phase 2) | Amylyx Pharmaceuticals Inc | Other | Combination, Small Molecule | ||
| ATH-1017 | NDX-1017 | Alzheimer's Disease (Phase 2) | Athira Pharma | Other | Small Molecule | |
| AZP2006 | AZP-2006 | Progressive Supranuclear Palsy (Phase 2), Alzheimer's Disease (Phase 1) | AlzProtect | Tau, Inflammation, Other | Small Molecule | |
| Acetyl-l-carnitine HCI | ALCAR | Alzheimer's Disease (Discontinued) | Sigma-Tau Pharmaceuticals | Other | Supplement, Dietary | |
| Allopregnanolone | brexanolone, 3α-hydroxy-5α-pregnan-20-one, 3α,5α-tetrahydroprogesterone |
Alzheimer's Disease (Phase 1) | Other Neurotransmitters, Other | Small Molecule | ||
| Alpha-Tocopherol | Vitamin E | Alzheimer's Disease (Phase 3) | Other | Supplement, Dietary | ||
| Ambroxol | Ambrosan, Mucosolvan | Parkinson's Disease (Phase 2), Parkinson's Disease Dementia (Phase 2) | alpha-synuclein, Other | Small Molecule | ||
| Anle138b | Multiple System Atrophy (Phase 1), Parkinson's Disease (Phase 1) | MODAG GmbH | Tau, alpha-synuclein, Other | Small Molecule | ||
| Apabetalone | RVX208, RVX000222 |
MCI-VaD (Phase 3) | Resverlogix Corporation | Other | Small Molecule | |
| Atuzaginstat | COR388 | Alzheimer's Disease (Phase 2/3) | Cortexyme, Inc. | Other | Small Molecule | |
| BI 409306 | SUB 166499 | Alzheimer's Disease (Discontinued), Schizophrenia (Phase 2) | Boehringer Ingelheim | Other Neurotransmitters, Other | Small Molecule | |
| BIIB094 | ION859, IONIS-BIIB7Rx |
Parkinson's Disease (Phase 1) | Biogen, IONIS Pharmaceuticals | Inflammation, Other | DNA/RNA-based | |
| BIIB118 | PF-05251749 | Alzheimer's Disease (Phase 1), Parkinson's Disease (Phase 1) | Biogen | Other | Small Molecule | |
| BPN14770 | Alzheimer's Disease (Phase 2) | Shionogi Pharma, Tetra Therapeutics | Cholinergic System, Other | Small Molecule | ||
| Bifidobacterium breve A1 | MCC1274, B. breve |
Mild Cognitive Impairment (Phase 2) | Morinaga Milk Industry Co., Ltd | Other | Supplement, Dietary | |
| Blarcamesine | Anavex 2-73 | Alzheimer's Disease (Phase 2/3), Parkinson's Disease Dementia (Phase 2), Parkinson's Disease (Phase 1) | Anavex Life Science Corp. | Other | Small Molecule | |
| Bosutinib | BOSULIF®, PF-5208763, SKI-606 |
Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) | Pfizer | Other | Small Molecule | Chronic myeloid leukemia |
| Bryostatin 1 | Alzheimer's Disease (Phase 2) | Neurotrope | Other | Other | ||
| CDNF | cerebral dopamine neurotrophic factor | Parkinson's Disease (Phase 1/2) | Herantis Pharma Plc, Renishaw plc. | Other | Procedural Intervention, Other | |
| CERE-110 | Nerve Growth Factor gene therapy | Alzheimer's Disease (Discontinued) | Sangamo BioSciences, Inc. | Other | DNA/RNA-based | |
| CHF 5074 | Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) | CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. | Amyloid-Related, Inflammation, Other | Small Molecule | ||
| CNM-Au8 | Gold nanocrystals | Parkinson's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 2/3) | Clene Nanomedicine, Inc. | Metals, Other | Other | |
| COGNIShunt™ | Alzheimer's Disease (Inactive) | Other | Procedural Intervention | None | ||
| Candesartan | Atacand, Candesartan cilexetil |
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Phase 2) | AstraZeneca, Takeda Pharmaceutical Company | Other | Small Molecule | Hypertension, congestive heart failure |
| Cerebrolysin | Alzheimer's Disease (Phase 2) | Ebewe Pharmaceutical | Other | Other | ||
| Circadin | Alzheimer's Disease (Phase 2) | Neurim Pharmaceuticals Ltd. | Other | Small Molecule | Insomnia | |
| Curcumin | diferuloylmethane, Longvida™ |
Alzheimer's Disease (Phase 2) | Verdure Sciences | Other, Unknown | Supplement, Dietary | None |
| DAYVIGO | Lemborexant, E2006 |
Alzheimer's Disease (Phase 2) | Eisai Co., Ltd. | Other | Small Molecule | Insomnia |
| DNL151 | BIIB122 | Parkinson's Disease (Phase 1) | Biogen, Denali Therapeutics Inc. | Inflammation, Other | Small Molecule | |
| DNL201 | Parkinson's Disease (Inactive) | Biogen, Denali Therapeutics Inc. | Inflammation, Other | Small Molecule | ||
| DNL343 | Amyotrophic Lateral Sclerosis (Phase 1) | Denali Therapeutics Inc. | Other | Small Molecule | ||
| Dapagliflozin | Farxiga, Forxiga, BMS 512148 |
Alzheimer's Disease (Phase 1/2) | AstraZeneca, Bristol-Myers Squibb | Other | Small Molecule | |
| Dapsone | Avlosulfon, Diaminodiphenylsulfone, DDS |
Alzheimer's Disease (Inactive) | Immune Network Ltd. | Other | Small Molecule | Leprosy, malaria, some bacterial skin infections |
| Dexpramipexole | R-pramipexole, RPPX, KNS-760704 , BIIB 050 |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) | Biogen, Knopp Biosciences LLC, Virginia Commonwealth University | Other Neurotransmitters, Other | Small Molecule | |
| Docosahexaenoic acid (DHA) | Omega 3 fatty acid | Alzheimer's Disease (Phase 4) | Martek Biosciences Corporation, NeuroBioPharm, Inc. | Other | Supplement, Dietary | |
| E2027 | Dementia with Lewy Bodies (Phase 2) | Eisai Co., Ltd. | Other | Small Molecule | ||
| EHT 0202 | Etazolate | Alzheimer's Disease (Phase 2) | ExonHit Therapeutics | Other | Small Molecule | None |
| Edonerpic | T-817 MA, T 817 | Alzheimer's Disease (Inactive) | Toyama Chemical Co., Ltd. | Other, Unknown | Small Molecule | |
| Empagliflozin | Jardiance, BI-10773 |
Alzheimer's Disease (Phase 1) | Boehringer Ingelheim, Eli Lilly & Co. | Other | Small Molecule | Type 2 Diabetes, Cardiovascular disease |
| Epigallocatechin Gallate (EGCG) | Sunphenon EGCg | Alzheimer's Disease (Phase 2/3), Down's Syndrome (Phase 2), Multiple System Atrophy (Phase 3) | Taiyo International | Amyloid-Related, Inflammation, Other | Supplement, Dietary | |
| Estrogen | Premarin™ | Alzheimer's Disease (Discontinued) | Other | Other | Hormone Replacement Therapy | |
| Exendin-4 | Exenatide, Byetta, Bydureon |
Alzheimer's Disease (Inactive), Parkinson's Disease (Phase 3) | Other | Small Molecule | Diabetes mellitus in US | |
| FRM-0334 | EVP-0334 | Frontotemporal Dementia (Phase 2) | FORUM Pharmaceuticals Inc. | Other | Small Molecule | |
| G-CSF | Filgrastim | Alzheimer's Disease (Phase 2) | Other | Small Molecule | Neutropenia in US | |
| GENUS | Gamma entrainment using sensory stimuli | Alzheimer's Disease (Phase 1) | Cognito Therapeutics, Inc. | Amyloid-Related, Inflammation, Other | Combination, Procedural Intervention | |
| GM-CSF Leukine | Sargramostim, Leukine® |
Alzheimer's Disease (Phase 2) | Genzyme, Sanofi | Inflammation, Other, Unknown | Other | Bone Marrow Stimulation |
| GRF6019 | Alzheimer's Disease (Phase 2) | Alkahest, Inc., Grifols Biologicals Inc. | Inflammation, Other, Unknown | Other | ||
| GV1001 | RIAVAXTM, Tertomotide | Alzheimer's Disease (Phase 2) | GemVax & KAEL Bio | Other | Immunotherapy (active) | Pancreatic cancer (Korea) |
| Idebenone | Catena, Sovrima |
Alzheimer's Disease (Discontinued) | Takeda Pharmaceutical Company | Other | Small Molecule | None |
| Ketasyn | Axona, Caprylic Acid, AC-1202 |
Alzheimer's Disease (Phase 4) | Cerecin Pte. Ltd. | Other | Supplement, Dietary | |
| LM11A-31-BHS | LM11A-31 | Alzheimer's Disease (Phase 2) | PharmatrophiX | Other | Small Molecule | |
| LTI-291 | Parkinson's Disease (Phase 2) | Lysosomal Therapeutics Inc. | Other | Small Molecule | ||
| Leuprolide | Leuprolide acetate | Alzheimer's Disease (Discontinued) | Other | Other | None | |
| Levetiracetam | Keppra | Alzheimer's Disease (Phase 3), Parkinson's Disease (Discontinued) | UCB S.A. | Amyloid-Related, Other | Small Molecule | Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries |
| Linopirdine | DuP996 | Alzheimer's Disease (Discontinued) | Other | Small Molecule | None | |
| Liraglutide | Victoza™, Saxenda™ |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2) | Novo Nordisk A/S | Other | Other | Diabetes, weight loss |
| Losartan | Cozaar®, MK0954 |
Alzheimer's Disease (Phase 2) | Merck | Other | Small Molecule | Hypertension, diabetic neuropathy |
| MEM 1003 | BAY Z 4406 | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued), Vascular Dementia (Discontinued), Bipolar Disorder (Discontinued) | Memory Pharmaceuticals Corporation | Other | Small Molecule | None |
| MSDC-0160 | Mitoglitazone | Alzheimer's Disease (Phase 2) | Metabolic Solutions Development Company | Other | Small Molecule | |
| Masitinib | Masivet, Kinavet, AB1010, Masitinib mesylate |
Alzheimer's Disease (Phase 3), Amyotrophic Lateral Sclerosis (Phase 3) | AB Science | Other | Small Molecule | |
| Melatonin | Alzheimer's Disease (Phase 2) | Other | Supplement, Dietary | None | ||
| Metformin | Glucophage, Glucophage XR |
Alzheimer's Disease (Phase 2/3) | Other | Small Molecule | Type 2 Diabetes | |
| Minocycline | Solodyn, Arestin, Minocin, Dynacin |
Alzheimer's Disease (Discontinued) | Other | Small Molecule | ||
| NIC5-15 | Pinitol, D-Pinitol |
Alzheimer's Disease (Phase 2) | Humanetics Pharmaceuticals Corporation | Amyloid-Related, Other | Small Molecule, Supplement, Dietary | |
| NPT520-34 | Amyotrophic Lateral Sclerosis (Phase 1), Parkinson's Disease (Phase 1) | Neuropore Therapies, Inc. | alpha-synuclein, Inflammation, Other | Small Molecule | ||
| Nasal Insulin | Detemir, Levemir, Humulin, Novolin |
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) | Amyloid-Related, Other | Small Molecule, Other | Diabetes | |
| Nicotinamide | Enduramide, Niacinamide, Nicotinic acid amide, Vitamin B3 |
Alzheimer's Disease (Phase 2) | Other | Small Molecule | ||
| Nilotinib | Tasigna, AMN107 |
Parkinson's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Alzheimer's Disease (Phase 2) | Novartis Pharmaceuticals Corporation | Other | Small Molecule | Chronic myeloid leukemia |
| Nilvadipine | Nilvad, Nivadil, ARC029 |
Alzheimer's Disease (Inactive) | Archer Pharmaceuticals, Inc. | Other | Small Molecule | |
| PR001 | PR001A | Parkinson's Disease (Phase 1/2) | Eli Lilly & Co., Prevail Therapeutics | Other | DNA/RNA-based | |
| PR006 | Frontotemporal Dementia (Phase 1) | Eli Lilly & Co., Prevail Therapeutics | Other | DNA/RNA-based | ||
| PRX-03140 | Potassium salt | Alzheimer's Disease (Inactive) | Epix Pharmaceuticals | Other | Small Molecule | |
| PU-AD | Alzheimer's Disease (Phase 1) | Samus Therapeutics | Other | Small Molecule | ||
| Pioglitazone | AD4833, Actos®, Glustin™, Piozone® |
Mild Cognitive Impairment (Phase 3) | Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. | Inflammation, Other | Small Molecule | Type 2 diabetes mellitus |
| Piromelatine | Neu-P11 | Alzheimer's Disease (Phase 2) | Neurim Pharmaceuticals Ltd. | Other Neurotransmitters, Other | Small Molecule | |
| Repetitive Transcranial Magnetic Stimulation | rTMS | Alzheimer's Disease (Phase 2) | Neuronix Ltd | Other | Procedural Intervention | |
| Resveratrol | trans-3,4',5-trihydroxystilbene | Alzheimer's Disease (Phase 3), Mild Cognitive Impairment (Phase 4) | Other | Small Molecule, Supplement, Dietary | ||
| Rilapladib | SB-659032 | Alzheimer's Disease (Phase 2) | GlaxoSmithKline (GSK) | Other | Small Molecule | |
| Riluzole | Rilutek®, RP 54274 |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) | Sanofi | Other Neurotransmitters, Other | Small Molecule | Amyotrophic Lateral Sclerosis in many countries |
| Rosiglitazone | Rosiglitazone maleate, Avandia |
Alzheimer's Disease (Discontinued) | GlaxoSmithKline (GSK) | Other | Small Molecule | |
| S-Equol | Aus-131 | Alzheimer's Disease (Phase 1) | Ausio Pharmaceuticals, LLC | Other | Small Molecule | |
| SAR110894D | Alzheimer's Disease (Phase 2) | Sanofi | Other | Small Molecule | ||
| Saracatinib | AZD0530 | Alzheimer's Disease (Discontinued), Parkinson's Disease (Phase 1) | AstraZeneca | Other | Small Molecule | |
| Semaglutide | Ozempic, Rybelsus |
Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 2) | Novo Nordisk A/S | Other | Other | Type 2 Diabetes |
| Sembragiline | RO4602522, RG1577 |
Alzheimer's Disease (Discontinued) | Evotech AG | Other Neurotransmitters, Other | Small Molecule | |
| Souvenaid | Fortasyn Connect | Alzheimer's Disease (Not Regulated) | Nutricia | Other | Supplement, Dietary | |
| Suvorexant | Belsomra, MK-4305 |
Alzheimer's Disease (Approved) | Merck | Other | Small Molecule | Insomnia, Insomnia in mild to moderate Alzheimer's disease |
| T3D-959 | DB959 | Alzheimer's Disease (Phase 2) | T3D Therapeutics, Inc. | Other | Small Molecule | |
| Telmisartan | Micardis | Alzheimer's Disease (Phase 2) | Boehringer Ingelheim | Other | Small Molecule | Hypertension |
| Tofersen | BIIB067, Ionis-SOD1Rx, ASO1 |
Amyotrophic Lateral Sclerosis (Phase 3) | Biogen, IONIS Pharmaceuticals | Other | DNA/RNA-based | |
| Tricaprilin | AC-1204 , Caprylic triglyceride |
Alzheimer's Disease (Phase 2/3) | Cerecin Pte. Ltd. | Other | Supplement, Dietary, Other | None |
| Valacyclovir | Valtrex, Valaciclovir, 256U87 |
Alzheimer's Disease (Phase 2) | GlaxoSmithKline (GSK) | Other | Small Molecule | Herpes virus outbreaks |
| Vascepa | Icosapent ethyl (IPE), Ethyl eicosapentaenoic acid (E-EPA), AMR101, Miraxion |
Alzheimer's Disease (Phase 2/3) | Other | Small Molecule | Severe hypertriglyceridemia, and to lower risk of cardiovascular events in people with elevated triglycerides | |
| Venglustat | Ibiglustat, GZ/SAR402671, Genz-682452 |
Parkinson's Disease (Inactive) | Genzyme, Sanofi | alpha-synuclein, Other | Small Molecule | |
| Xaliproden | SR 57746A | Alzheimer's Disease (Discontinued) | Sanofi | Other Neurotransmitters, Other | Small Molecule | |
| Xanamem | UE 2343 | Alzheimer's Disease (Phase 2) | Actinogen Medical | Other | Small Molecule | |
| YTX-7739 | Parkinson's Disease (Phase 1) | Yumanity Therapeutics | Other | Small Molecule | ||
| Young Plasma | Progressive Supranuclear Palsy (Inactive), Alzheimer's Disease (Inactive) | Alkahest, Inc., Grifols Biologicals Inc. | Inflammation, Other, Unknown | Other | ||
| kMCT-ONS | medium chain triglyceride-based ketogenic oral nutritional supplement, kMCT | Alzheimer's Disease (Not Regulated) | Nestlé Health Science | Other | Supplement, Dietary |