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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
DAYVIGO Lemborexant,
E2006
Alzheimer's Disease (Phase 2) Eisai Co., Ltd. Other Small Molecule Insomnia
ABT-384 Alzheimer's Disease (Discontinued) AbbVie Other Small Molecule
ABT-957 Alzheimer's Disease (Phase 1) AbbVie Other Small Molecule
AL001 Frontotemporal Dementia (Phase 2) Alector Other Immunotherapy (passive)
AMX0035 Amyotrophic Lateral Sclerosis (Phase 2), Alzheimer's Disease (Phase 2) Amylyx Pharmaceuticals Inc Other Combination, Small Molecule
AZP2006 AZP-2006 Progressive Supranuclear Palsy (Phase 2), Alzheimer's Disease (Phase 1) AlzProtect Tau, Inflammation, Other Small Molecule
Acetyl-l-carnitine HCI ALCAR Alzheimer's Disease (Discontinued) Sigma-Tau Pharmaceuticals Other Supplement, Dietary
Allopregnanolone brexanolone,
3α-hydroxy-5α-pregnan-20-one,
3α,5α-tetrahydroprogesterone
Alzheimer's Disease (Phase 1) Other Neurotransmitters, Other Small Molecule
Alpha-Tocopherol Vitamin E Alzheimer's Disease (Phase 3) Other Supplement, Dietary
Ambroxol Ambrosan, Mucosolvan Parkinson's Disease (Phase 2), Parkinson's Disease Dementia (Phase 2) alpha-synuclein, Other Small Molecule
Anle138b Multiple System Atrophy (Phase 1) Tau, alpha-synuclein, Other Small Molecule
Apabetalone RVX208,
RVX000222
MCI-VaD (Phase 3) Resverlogix Corporation Other Small Molecule
BI 409306 SUB 166499 Alzheimer's Disease (Discontinued), Schizophrenia (Phase 2) Boehringer Ingelheim Other Neurotransmitters, Other Small Molecule
BIIB094 ION859,
IONIS-BIIB7Rx
Parkinson's Disease (Phase 1) Biogen, IONIS Pharmaceuticals Inflammation, Other DNA/RNA-based
BPN14770 Alzheimer's Disease (Phase 2) Shionogi Pharma, Tetra Therapeutics Cholinergic System, Other Small Molecule
Bifidobacterium breve A1 MCC1274,
B. breve
Mild Cognitive Impairment (Phase 2) Morinaga Milk Industry Co., Ltd Other Supplement, Dietary
Blarcamesine Anavex 2-73 Alzheimer's Disease (Phase 2), Parkinson's Disease Dementia (Phase 2) Anavex Life Science Corp. Other Small Molecule
Bosutinib BOSULIF®,
PF-5208763,
SKI-606
Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) Pfizer Other Small Molecule Chronic myeloid leukemia
Bryostatin 1 Alzheimer's Disease (Phase 2) Neurotrope Other Other
CDNF cerebral dopamine neurotrophic factor Parkinson's Disease (Phase 1/2) Herantis Pharma Plc, Renishaw plc. Other Procedural Intervention, Other
CERE-110 Nerve Growth Factor gene therapy Alzheimer's Disease (Discontinued) Sangamo BioSciences, Inc. Other DNA/RNA-based
CHF 5074 Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. Amyloid-Related, Inflammation, Other Small Molecule
COGNIShunt™ Alzheimer's Disease (Inactive) Other Procedural Intervention None
COR388 Alzheimer's Disease (Phase 1) Cortexyme, Inc. Other Small Molecule
Cerebrolysin Alzheimer's Disease (Phase 2) Ebewe Pharmaceutical Other Other
Circadin Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Small Molecule Insomnia
Curcumin diferuloylmethane,
Longvida™
Alzheimer's Disease (Phase 2) Verdure Sciences Other, Unknown Supplement, Dietary None
DNL151 Parkinson's Disease (Phase 1) Denali Therapeutics Inc. Inflammation, Other Small Molecule
DNL201 Parkinson's Disease (Phase 1) Denali Therapeutics Inc. Inflammation, Other Small Molecule
Dapagliflozin Farxiga,
Forxiga,
BMS 512148
Alzheimer's Disease (Phase 1/2) AstraZeneca, Bristol-Myers Squibb Other Small Molecule
Dapsone Avlosulfon,
Diaminodiphenylsulfone,
DDS
Alzheimer's Disease (Inactive) Immune Network Ltd. Other Small Molecule Leprosy, malaria, some bacterial skin infections
Dexpramipexole R-pramipexole,
RPPX,
KNS-760704 ,
BIIB 050
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) Biogen, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule
Docosahexaenoic acid (DHA) Omega 3 fatty acid Alzheimer's Disease (Phase 4) Martek Biosciences Corporation, NeuroBioPharm, Inc. Other Supplement, Dietary
EHT 0202 Etazolate Alzheimer's Disease (Phase 2) ExonHit Therapeutics Other Small Molecule None
Edonerpic T-817 MA, T 817 Alzheimer's Disease (Inactive) Toyama Chemical Co., Ltd. Other, Unknown Small Molecule
Empagliflozin Jardiance,
BI-10773
Alzheimer's Disease (Phase 1) Boehringer Ingelheim, Eli Lilly & Co. Other Small Molecule Type 2 Diabetes, Cardiovascular disease
Epigallocatechin Gallate (EGCG) Sunphenon EGCg Alzheimer's Disease (Phase 2/3), Down's Syndrome (Phase 2), Multiple System Atrophy (Phase 3) Taiyo International Amyloid-Related, Inflammation, Other Supplement, Dietary
Estrogen Premarin™ Alzheimer's Disease (Discontinued) Other Other Hormone Replacement Therapy
Exendin-4 Exenatide,
Byetta,
Bydureon
Alzheimer's Disease (Inactive), Parkinson's Disease (Phase 3) Other Small Molecule Diabetes mellitus in US
FRM-0334 EVP-0334 Frontotemporal Dementia (Phase 2) FORUM Pharmaceuticals Inc. Other Small Molecule
G-CSF Filgrastim Alzheimer's Disease (Phase 2) Other Small Molecule Neutropenia in US
GENUS Gamma entrainment using sensory stimuli Alzheimer's Disease (Phase 1) Cognito Therapeutics, Inc. Amyloid-Related, Inflammation, Other Combination, Procedural Intervention
GM-CSF Leukine Sargramostim,
Leukine®
Alzheimer's Disease (Phase 2) Genzyme, Sanofi Inflammation, Other, Unknown Other Bone Marrow Stimulation
GRF6019 Alzheimer's Disease (Phase 2) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other
GV1001 RIAVAXTM, Tertomotide Alzheimer's Disease (Phase 2) GemVax & KAEL Bio Other Immunotherapy (active) Pancreatic cancer (Korea)
Idebenone Catena,
Sovrima
Alzheimer's Disease (Discontinued) Takeda Pharmaceutical Company Other Small Molecule None
Ketasyn Axona,
Caprylic Acid,
AC-1202
Alzheimer's Disease (Phase 4) Accera, Inc. Other Supplement, Dietary
LM11A-31-BHS LM11A-31 Alzheimer's Disease (Phase 2) PharmatrophiX Other Small Molecule
LTI-291 Parkinson's Disease (Phase 2) Lysosomal Therapeutics Inc. Other Small Molecule
Leuprolide Leuprolide acetate Alzheimer's Disease (Discontinued) Other Other None
Levetiracetam Keppra Alzheimer's Disease (Phase 3), Parkinson's Disease (Discontinued) UCB S.A. Amyloid-Related, Other Small Molecule Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries
Linopirdine DuP996 Alzheimer's Disease (Discontinued) Other Small Molecule None
Liraglutide Victoza™,
Saxenda™
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2) Novo Nordisk A/S Other Other Diabetes, weight loss
MEM 1003 BAY Z 4406 Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued), Vascular Dementia (Discontinued), Bipolar Disorder (Discontinued) Memory Pharmaceuticals Corporation Other Small Molecule None
MSDC-0160 Mitoglitazone Alzheimer's Disease (Phase 2) Metabolic Solutions Development Company Other Small Molecule
Masitinib Masivet,
Kinavet,
AB1010,
Masitinib mesylate
Alzheimer's Disease (Phase 3), Amyotrophic Lateral Sclerosis (Phase 3) AB Science Other Small Molecule
Melatonin Alzheimer's Disease (Phase 2) Other Supplement, Dietary None
Metformin Glucophage,
Glucophage XR
Alzheimer's Disease (Phase 2/3) Other Small Molecule Type 2 Diabetes
Minocycline Solodyn,
Arestin,
Minocin,
Dynacin
Alzheimer's Disease (Discontinued) Other Small Molecule
NDX-1017 Alzheimer's Disease (Phase 1) Athira Pharma Other Small Molecule
NIC5-15 Pinitol,
D-Pinitol
Alzheimer's Disease (Phase 2) Humanetics Pharmaceuticals Corporation Amyloid-Related, Other Small Molecule, Supplement, Dietary
NPT520-34 Amyotrophic Lateral Sclerosis (Phase 1), Parkinson's Disease (Phase 1) Neuropore Therapies, Inc. alpha-synuclein, Inflammation, Other Small Molecule
Nasal Insulin Detemir,
Levemir,
Humulin,
Novolin
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) Amyloid-Related, Other Small Molecule, Other Diabetes
Nicotinamide Enduramide,
Niacinamide,
Nicotinic acid amide,
Vitamin B3
Alzheimer's Disease (Phase 2) Other Small Molecule
Nilotinib Tasigna,
AMN107
Parkinson's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Alzheimer's Disease (Phase 2) Novartis Pharmaceuticals Corporation Other Small Molecule Chronic myeloid leukemia
Nilvadipine Nilvad,
Nivadil,
ARC029
Alzheimer's Disease (Inactive) Archer Pharmaceuticals, Inc. Other Small Molecule
PF-05251749 Alzheimer's Disease (Discontinued) Pfizer Other Small Molecule
PR001 PR001A Parkinson's Disease (Phase 1/2) Prevail Therapeutics Other DNA/RNA-based
PRX-03140 Potassium salt Alzheimer's Disease (Inactive) Epix Pharmaceuticals Other Small Molecule
PU-AD Alzheimer's Disease (Phase 1) Samus Therapeutics Other Small Molecule
Pioglitazone AD4833,
Actos®,
Glustin™,
Piozone®
Mild Cognitive Impairment (Phase 3) Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. Inflammation, Other Small Molecule Type 2 diabetes mellitus
Piromelatine Neu-P11 Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Neurotransmitters, Other Small Molecule
Repetitive Transcranial Magnetic Stimulation rTMS Alzheimer's Disease (Phase 2) Neuronix Ltd Other Procedural Intervention
Resveratrol trans-3,4',5-trihydroxystilbene Alzheimer's Disease (Phase 3), Mild Cognitive Impairment (Phase 4) Other Small Molecule, Supplement, Dietary
Rilapladib SB-659032 Alzheimer's Disease (Phase 2) GlaxoSmithKline (GSK) Other Small Molecule
Riluzole Rilutek®,
RP 54274
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule Amyotrophic Lateral Sclerosis in many countries
Rosiglitazone Rosiglitazone maleate,
Avandia
Alzheimer's Disease (Discontinued) GlaxoSmithKline (GSK) Other Small Molecule
S-Equol Aus-131 Alzheimer's Disease (Phase 1) Ausio Pharmaceuticals, LLC Other Small Molecule
SAR110894D Alzheimer's Disease (Phase 2) Sanofi Other Small Molecule
Saracatinib AZD0530 Alzheimer's Disease (Discontinued), Parkinson's Disease (Phase 1) AstraZeneca Other Small Molecule
Semaglutide Ozempic,
Rybelsus
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2) Novo Nordisk A/S Other Other Type 2 Diabetes
Sembragiline RO4602522,
RG1577
Alzheimer's Disease (Discontinued) Evotech AG Other Neurotransmitters, Other Small Molecule
Souvenaid FortasynTM Connect Alzheimer's Disease (Not Regulated) Other Supplement, Dietary
Suvorexant Belsomra,
MK-4305
Alzheimer's Disease (Approved) Merck Other Small Molecule Insomnia, Insomnia in mild to moderate Alzheimer's disease
T3D-959 DB959 Alzheimer's Disease (Phase 2) T3D Therapeutics, Inc. Other Small Molecule
Telmisartan Micardis Alzheimer's Disease (Phase 2) Boehringer Ingelheim Other Small Molecule Hypertension
Tofersen BIIB067,
Ionis-SOD1Rx,
ASO1
Amyotrophic Lateral Sclerosis (Phase 3) Biogen, IONIS Pharmaceuticals Other DNA/RNA-based
Tricaprilin AC-1204 ,
Caprylic triglyceride
Alzheimer's Disease (Phase 2/3) Accera, Inc. Other Supplement, Dietary, Other None
Valacyclovir Valtrex,
Valaciclovir,
256U87
Alzheimer's Disease (Phase 2) GlaxoSmithKline (GSK) Other Small Molecule Herpes virus outbreaks
Vascepa Icosapent ethyl (IPE),
Ethyl eicosapentaenoic acid (E-EPA),
AMR101,
Miraxion
Alzheimer's Disease (Phase 2/3) Other Small Molecule Severe hypertriglyceridemia, and to lower risk of cardiovascular events in people with elevated triglycerides
Venglustat Ibiglustat,
GZ/SAR402671
Parkinson's Disease (Phase 2) Genzyme, Sanofi alpha-synuclein, Other Small Molecule
Xaliproden SR 57746A Alzheimer's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule
Xanamem UE 2343 Alzheimer's Disease (Phase 2) Actinogen Medical Other Small Molecule
Young Plasma Progressive Supranuclear Palsy (Inactive), Alzheimer's Disease (Inactive) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other