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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
AL002 Alzheimer's Disease (Phase 1) AbbVie, Alector Inflammation Immunotherapy (passive)
AL003 Alzheimer's Disease (Phase 1) AbbVie, Alector Inflammation Immunotherapy (active)
ALZT-OP1 Cromolyn sodium, Intal,
Ibuprofen
Alzheimer's Disease (Phase 3) AZTherapies, Inc. Amyloid-Related, Inflammation Combination, Small Molecule
AZP2006 AZP-2006 Progressive Supranuclear Palsy (Phase 2), Alzheimer's Disease (Phase 1) AlzProtect Tau, Inflammation, Other Small Molecule
Azeliragon PF-04494700,
TTP488
Alzheimer's Disease (Phase 2/3) Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC Amyloid-Related, Inflammation Small Molecule
BIIB094 ION859,
IONIS-BIIB7Rx
Parkinson's Disease (Phase 1) Biogen, IONIS Pharmaceuticals Inflammation, Other DNA/RNA-based
CHF 5074 Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. Amyloid-Related, Inflammation, Other Small Molecule
Celecoxib Celebrex Alzheimer's Disease (Discontinued) Pfizer Inflammation Small Molecule Pain, Arthritis
DNL151 Parkinson's Disease (Phase 1) Denali Therapeutics Inc. Inflammation, Other Small Molecule
DNL201 Parkinson's Disease (Phase 1) Denali Therapeutics Inc. Inflammation, Other Small Molecule
DNL747 SAR 443060 Alzheimer's Disease (Inactive), Amyotrophic Lateral Sclerosis (Inactive) Denali Therapeutics Inc., Sanofi Inflammation Small Molecule
Epigallocatechin Gallate (EGCG) Sunphenon EGCg Alzheimer's Disease (Phase 2/3), Down's Syndrome (Phase 2), Multiple System Atrophy (Phase 3) Taiyo International Amyloid-Related, Inflammation, Other Supplement, Dietary
Etanercept Enbrel™ Alzheimer's Disease (Phase 2) Amgen, Inc., Pfizer Inflammation Immunotherapy (passive) Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondilysis
GC 021109 Alzheimer's Disease (Phase 1) GliaCure Inflammation Small Molecule
GENUS Gamma entrainment using sensory stimuli Alzheimer's Disease (Phase 1) Cognito Therapeutics, Inc. Amyloid-Related, Inflammation, Other Combination, Procedural Intervention
GM-CSF Leukine Sargramostim,
Leukine®
Alzheimer's Disease (Phase 2) Genzyme, Sanofi Inflammation, Other, Unknown Other Bone Marrow Stimulation
GRF6019 Alzheimer's Disease (Phase 2) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other
GV-971 sodium oligomannate,
sodium oligo-mannurarate
Alzheimer's Disease (Phase 3) Shanghai Green Valley Pharmaceuticals Amyloid-Related, Inflammation Small Molecule
Gammagard® Intravenous Immunoglobulin,
IVIg
Alzheimer's Disease (Discontinued) Baxter Healthcare Amyloid-Related, Inflammation Immunotherapy (passive) Immunodeficiency conditions
Gamunex Intravenous Immunoglobulin,
Human Albumin Combined With Flebogamma
Alzheimer's Disease (Phase 2/3) Grifols Biologicals Inc. Amyloid-Related, Inflammation Combination, Immunotherapy (passive) Immunodeficiency, chronic inflammatory demyelinating neuropathy
HF0220 Alzheimer's Disease (Discontinued) Newron Inflammation Small Molecule
Ibuprofen Advil™,
Nuprin™ ,
Motrin™
Alzheimer's Disease (Discontinued) Amyloid-Related, Inflammation Small Molecule Pain and Fever
Inzomelid Alzheimer's Disease (Phase 1), Parkinson's Disease (Phase 1) Inflazome Ltd. Inflammation Small Molecule
JNJ-40346527 Edicotinib,
JNJ-527,
PRV-6527
Alzheimer's Disease (Phase 1) Janssen Inflammation Small Molecule
Lornoxicam Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) JSW Lifesciences Inflammation Small Molecule Pain in US
MW151 MW01-2-151SRM,
Minozac,
MW01-2-151WH,
compound 17
Alzheimer's Disease (Phase 1) ImmunoChem Therapeutics, LLC Inflammation Small Molecule
Montelukast Singulair, MK0476 Alzheimer's Disease (Phase 2) Intelgenx Inflammation Small Molecule Asthma
NPT520-34 Amyotrophic Lateral Sclerosis (Phase 1), Parkinson's Disease (Phase 1) Neuropore Therapies, Inc. alpha-synuclein, Inflammation, Other Small Molecule
Naproxen Aleve™,
Anaprox™,
Naprosyn™
Alzheimer's Disease (Discontinued) Procter & Gamble Inflammation Small Molecule Over-the-counter drug for reduction of pain, fever, inflammation, and stiffness.
Neflamapimod VX-745 Alzheimer's Disease (Phase 2) EIP Pharma, LLC Inflammation Small Molecule
Octagam®10% Intravenous Immunoglobulin,
NewGam
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Inactive) Octapharma Amyloid-Related, Inflammation Immunotherapy (passive) Immunodeficiency disorders
PQ912 Alzheimer's Disease (Phase 2) Probiodrug AG, Vivoryon Therapeutics AG Amyloid-Related, Inflammation Small Molecule
Pioglitazone AD4833,
Actos®,
Glustin™,
Piozone®
Mild Cognitive Impairment (Phase 3) Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. Inflammation, Other Small Molecule Type 2 diabetes mellitus
Prednisone Alzheimer's Disease (Discontinued) Inflammation Small Molecule
Rofecoxib Vioxx™ Alzheimer's Disease (Discontinued) Merck Inflammation Small Molecule Withdrawn from market
Thalidomide Thalomid® Alzheimer's Disease (Phase 2/3) Celgene Corporation Amyloid-Related, Inflammation Small Molecule
XPro1595 INB03, NeuLiv, XENP1595, DN-TNF, XENP345 Alzheimer's Disease (Phase 1) INmune Bio Inc. Inflammation Other
Young Plasma Progressive Supranuclear Palsy (Inactive), Alzheimer's Disease (Inactive) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other