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Name Synonyms FDA Status Company Target Type Therapy Type Approved
AAB-003 PF-05236812 Alzheimer's Disease (Discontinued) Janssen, Pfizer Amyloid-Related Immunotherapy (passive)
AAVrh.10-APOE2 AAVrh.10hAPOE2 Alzheimer's Disease (Phase 1) Amyloid-Related DNA/RNA-based
ABvac 40 Alzheimer's Disease (Phase 2) Araclon Biotech Amyloid-Related Immunotherapy (active)
ACI-24 Pal1-15 acetate salt Alzheimer's Disease (Phase 2), Down's Syndrome (Phase 2) AC Immune SA Amyloid-Related Immunotherapy (active)
AGB101 levetiracetam MCI-AD (Phase 3) AgeneBio, Inc. Amyloid-Related Small Molecule
ALZ-801 NRM-8499, homotaurine, 3-APS Alzheimer's Disease (Phase 3) Alzheon Inc. Amyloid-Related Small Molecule
ALZT-OP1 Cromolyn sodium, Intal,
Alzheimer's Disease (Phase 3) AZTherapies, Inc. Amyloid-Related, Inflammation Combination, Small Molecule
AN-1792 AIP 001 Alzheimer's Disease (Discontinued) Janssen, Pfizer Amyloid-Related Immunotherapy (active) None
Acitretin Soriatane ,
RO 101670
Alzheimer's Disease (Phase 2) Actavis, Allergan plc Amyloid-Related Small Molecule Psoriasis in US
Aducanumab BIIB037 Alzheimer's Disease (Phase 3) Biogen, Neurimmune Amyloid-Related Immunotherapy (passive)
Affitope AD02 Alzheimer's Disease (Discontinued) AFFiRiS AG Amyloid-Related Immunotherapy (active)
Alzhemed™ Vivimind™,
Alzheimer's Disease (Discontinued) Neurochem, Inc. Amyloid-Related Supplement, Dietary None
Amilomotide CAD106 Alzheimer's Disease (Inactive) Novartis Pharmaceuticals Corporation Amyloid-Related Immunotherapy (active) None
Atabecestat JNJ-54861911 ,
BACE inhibitor
Alzheimer's Disease (Discontinued) Janssen, Shionogi Pharma Amyloid-Related Small Molecule
Avagacestat BMS-708163 Alzheimer's Disease (Discontinued) Bristol-Myers Squibb Amyloid-Related Small Molecule
Azeliragon PF-04494700,
Alzheimer's Disease (Phase 2/3) Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC Amyloid-Related, Inflammation Small Molecule
BI 1181181 VTP 37948,
BACE inhibitor
Alzheimer's Disease (Discontinued) Boehringer Ingelheim, Vitae Pharmaceuticals Amyloid-Related Small Molecule
Bapineuzumab AAB-001 Alzheimer's Disease (Discontinued) Janssen, Pfizer Amyloid-Related Immunotherapy (passive)
Bexarotene Targretin® Alzheimer's Disease (Phase 2) Ligand Pharmaceuticals, Inc., ReXceptor Inc. Amyloid-Related, Unknown Small Molecule Cutaneous T-cell Lymphoma in US
CHF 5074 Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. Amyloid-Related, Inflammation, Other Small Molecule
Clioquinol iodochlorhydroxyquin,
Alzheimer's Disease (Discontinued) Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule
Crenezumab MABT5102A ,
Alzheimer's Disease (Phase 2) AC Immune SA, Genentech, Hoffmann-La Roche Amyloid-Related Immunotherapy (passive) None
Donanemab N3pG-Aβ Monoclonal Antibody,
Alzheimer's Disease (Phase 2) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
ELND005 AZD-103,
Alzheimer's Disease (Inactive) Elan Corporation, Opko Health, Speranza Therapeutics, Transition Therapeutics, Inc. Amyloid-Related Small Molecule None
EVP-0962 EVP 0015962 Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) FORUM Pharmaceuticals Inc. Amyloid-Related Small Molecule
Elayta CT1812 Alzheimer's Disease (Phase 2) Cognition Therapeutics Inc. Amyloid-Related Small Molecule
Elenbecestat E2609,
BACE inhibitor
Alzheimer's Disease (Discontinued) Biogen, Eisai Co., Ltd. Amyloid-Related Small Molecule
Epigallocatechin Gallate (EGCG) Sunphenon EGCg Alzheimer's Disease (Phase 2/3), Down's Syndrome (Phase 2), Multiple System Atrophy (Phase 3) Taiyo International Amyloid-Related, Inflammation, Other Supplement, Dietary
Flurizan™ tarenflurbil ,
Alzheimer's Disease (Discontinued) Myriad Genetics & Laboratories Amyloid-Related Small Molecule None
GENUS Gamma entrainment using sensory stimuli Alzheimer's Disease (Phase 1) Cognito Therapeutics, Inc. Amyloid-Related, Inflammation, Other Combination, Procedural Intervention
GSK933776 Alzheimer's Disease (Inactive) GlaxoSmithKline (GSK) Amyloid-Related Immunotherapy (passive)
GV-971 sodium oligomannate,
sodium oligo-mannurarate
Alzheimer's Disease (Phase 3) Shanghai Green Valley Pharmaceuticals Amyloid-Related, Inflammation Small Molecule
Gammagard® Intravenous Immunoglobulin,
Alzheimer's Disease (Discontinued) Baxter Healthcare Amyloid-Related, Inflammation Immunotherapy (passive) Immunodeficiency conditions
Gamunex Intravenous Immunoglobulin,
Human Albumin Combined With Flebogamma
Alzheimer's Disease (Phase 2/3) Grifols Biologicals Inc. Amyloid-Related, Inflammation Combination, Immunotherapy (passive) Immunodeficiency, chronic inflammatory demyelinating neuropathy
Gantenerumab RO4909832,
Alzheimer's Disease (Phase 3) Chugai Pharmaceutical Co., Ltd., Hoffmann-La Roche Amyloid-Related Immunotherapy (passive)
Ibuprofen Advil™,
Nuprin™ ,
Alzheimer's Disease (Discontinued) Amyloid-Related, Inflammation Small Molecule Pain and Fever
LY2599666 Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
LY2886721 BACE inhibitor Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule
LY3202626 BACE Inhibitor Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule
LY3372993 Alzheimer's Disease (Phase 1) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
Lanabecestat AZD3293 ,
BACE inhibitor
Alzheimer's Disease (Discontinued) AstraZeneca, Eli Lilly & Co. Amyloid-Related Small Molecule
Lecanemab BAN2401 ,
Alzheimer's Disease (Phase 3) Biogen, Eisai Co., Ltd. Amyloid-Related Immunotherapy (passive)
Levetiracetam Keppra Alzheimer's Disease (Phase 3), Parkinson's Disease (Discontinued) UCB S.A. Amyloid-Related, Other Small Molecule Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries
Lu AF20513 Alzheimer's Disease (Phase 1) H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Amyloid-Related Immunotherapy (active)
MEDI1814 Alzheimer's Disease (Phase 1) AstraZeneca, Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
NIC5-15 Pinitol,
Alzheimer's Disease (Phase 2) Humanetics Pharmaceuticals Corporation Amyloid-Related, Other Small Molecule, Supplement, Dietary
Nasal Insulin Detemir,
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) Amyloid-Related, Other Small Molecule, Other Diabetes
Octagam®10% Intravenous Immunoglobulin,
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Inactive) Octapharma Amyloid-Related, Inflammation Immunotherapy (passive) Immunodeficiency disorders
PBT2 PBT-2 Alzheimer's Disease (Phase 2), Huntington's Disease (Phase 2) Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule
PF-06648671 Alzheimer's Disease (Discontinued) Pfizer Amyloid-Related Small Molecule
PF-06751979 BACE inhibitor Alzheimer's Disease (Discontinued) Pfizer Amyloid-Related Small Molecule
PRI-002 RD2,
contraloid acetate
Alzheimer's Disease (Phase 1) Priavoid GmbH Amyloid-Related Small Molecule
Ponezumab PF-04360365 Alzheimer's Disease (Discontinued), Cerebral Amyloid Angiopathy (Discontinued) Pfizer Amyloid-Related Immunotherapy (passive) None
Posiphen ANVS-401,
Posiphen tartrate
Alzheimer's Disease (Phase 2) Annovis Bio Amyloid-Related, alpha-synuclein Small Molecule
RG7129 RO5508887,
BACE Inhibitor
Alzheimer's Disease (Discontinued) Roche Amyloid-Related Small Molecule
RO7126209 RG6102,
Brain shuttle gantenerumab
Alzheimer's Disease (Phase 1) Hoffmann-La Roche Amyloid-Related Immunotherapy (passive)
SAR228810 Alzheimer's Disease (Phase 1) Sanofi Amyloid-Related Immunotherapy (passive)
Semagacestat LY450139 Dihydrate ,
hydroxylvaleryl monobenzocaprolactam
Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule None
Solanezumab LY2062430 Alzheimer's Disease (Phase 3) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive) None
Sumifilam PTI-125 Alzheimer's Disease (Phase 2) Cassava Sciences Amyloid-Related Small Molecule
Thalidomide Thalomid® Alzheimer's Disease (Phase 2/3) Celgene Corporation Amyloid-Related, Inflammation Small Molecule
UB-311 Alzheimer's Disease (Phase 3) United Neuroscience Amyloid-Related Immunotherapy (active)
Umibecestat CNP520,
BACE Inhibitor
Alzheimer's Disease (Phase 2/3) Amgen, Inc., Novartis Pharmaceuticals Corporation Amyloid-Related Small Molecule
Vanutide cridificar ACC-001,
Alzheimer's Disease (Discontinued) Janssen Amyloid-Related Immunotherapy (active) None
Varoglutamstat PQ912 Alzheimer's Disease (Phase 2) Probiodrug AG, Vivoryon Therapeutics AG Amyloid-Related, Inflammation Small Molecule
Verubecestat MK-8931, MK-8931-009 ,
BACE inhibitor
Alzheimer's Disease (Discontinued) Merck Amyloid-Related Small Molecule