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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
AL001 Frontotemporal Dementia (Phase 1) Other Immunotherapy (passive)
C2N 8E12 ABBV-8E12 Progressive Supranuclear Palsy (Phase 2), Alzheimer's Disease (Phase 2) AbbVie, C2N Diagnostics, LLC Tau Immunotherapy (passive)
Davunetide NAP,
AL-108
Mild Cognitive Impairment (Discontinued), Progressive Supranuclear Palsy (Discontinued), Schizophrenia (Discontinued), Frontotemporal Dementia (Inactive) Allon Therapeutics Inc., Paladin Labs Inc. Tau Other
FRM-0334 EVP-0334 Frontotemporal Dementia (Phase 2) FORUM Pharmaceuticals Inc. Other Small Molecule
Gosuranemab BIIB092,
BMS-986168, IPN007
Progressive Supranuclear Palsy (Phase 2), Alzheimer's Disease (Phase 2) Biogen, Bristol-Myers Squibb Tau Immunotherapy (passive)
LMTM TRx0237, LMT-X,
Methylene Blue,
Tau aggregation inhibitor (TAI)
Alzheimer's Disease (Phase 3), Frontotemporal Dementia (Phase 3) TauRx Therapeutics Ltd Tau Small Molecule Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
Nimodipine Nimotop Frontotemporal Dementia (Phase 1) Bayer Metals Small Molecule Subarachnoid hemorrhage
TPI 287 Alzheimer's Disease (Phase 1), Corticobasal Degeneration (Phase 1), Progressive Supranuclear Palsy (Phase 1) Cortice Biosciences Tau Small Molecule
Tideglusib NP031112,
Nypta® ,
Zentylor™ ,
Glycogen synthase kinase 3 inhibitor,
NP12
Alzheimer's Disease (Discontinued), Progressive Supranuclear Palsy (Discontinued) Zeltia Group Tau Small Molecule
UCB0107 UCB 0107 Progressive Supranuclear Palsy (Phase 1) UCB S.A. Tau Immunotherapy (passive)
Young Plasma Progressive Supranuclear Palsy (Phase 1), Alzheimer's Disease (Phase 1) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other