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Name Synonyms FDA Status Company Target Type Therapy Type Approved
ABBV-8E12 C2N 8E12 Progressive Supranuclear Palsy (Discontinued), Alzheimer's Disease (Phase 2) AbbVie, C2N Diagnostics, LLC Tau Immunotherapy (passive)
AL001 Frontotemporal Dementia (Phase 2) Alector Other Immunotherapy (passive)
ASN120290 ASN-561 Progressive Supranuclear Palsy (Phase 1) Asceneuron SA Tau Small Molecule
AZP2006 AZP-2006 Progressive Supranuclear Palsy (Phase 2), Alzheimer's Disease (Phase 1) AlzProtect Tau, Inflammation, Other Small Molecule
Davunetide NAP,
Mild Cognitive Impairment (Discontinued), Progressive Supranuclear Palsy (Discontinued), Schizophrenia (Discontinued), Frontotemporal Dementia (Inactive) Allon Therapeutics Inc., Paladin Labs Inc. Tau Other
FRM-0334 EVP-0334 Frontotemporal Dementia (Phase 2) FORUM Pharmaceuticals Inc. Other Small Molecule
Gosuranemab BIIB092,
BMS-986168, IPN007
Progressive Supranuclear Palsy (Discontinued), Alzheimer's Disease (Phase 2) Biogen, Bristol-Myers Squibb Tau Immunotherapy (passive)
LMTM TRx0237, LMT-X,
Methylene Blue,
Tau aggregation inhibitor (TAI)
Alzheimer's Disease (Phase 3), Frontotemporal Dementia (Phase 3) TauRx Therapeutics Ltd Tau Small Molecule Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
Nimodipine Nimotop Frontotemporal Dementia (Phase 1) Bayer Metals Small Molecule Subarachnoid hemorrhage
TPI 287 Alzheimer's Disease (Inactive), Corticobasal Degeneration (Inactive), Progressive Supranuclear Palsy (Phase 1) Cortice Biosciences Tau Small Molecule
Tideglusib NP031112,
Nypta® ,
Zentylor™ ,
Glycogen synthase kinase 3 inhibitor,
Alzheimer's Disease (Discontinued), Progressive Supranuclear Palsy (Discontinued) Zeltia Group Tau Small Molecule
UCB0107 UCB 0107 Progressive Supranuclear Palsy (Phase 1) UCB S.A. Tau Immunotherapy (passive)
Young Plasma Progressive Supranuclear Palsy (Inactive), Alzheimer's Disease (Inactive) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other