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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
AADvac1 Axon peptide 108 conjugated to KLH Alzheimer's Disease (Phase 2), Progressive Nonfluent Aphasia (Phase 1) Axon Neuroscience SE Tau Immunotherapy (active)
ACI-35 VAC20121,
JNJ-64042056
Alzheimer's Disease (Phase 2/3) AC Immune SA, Janssen Tau Immunotherapy (active)
ACI-3024 Tau MorphomerTM Alzheimer's Disease (Inactive), Other Tauopathy (Phase 0) AC Immune SA Tau Small Molecule
APNmAb005 RAA7 Alzheimer's Disease (Phase 1) Aprinoia Therapeutics Tau Immunotherapy (passive)
ASN51 ASN121151 Alzheimer's Disease (Phase 1) Asceneuron SA Tau Small Molecule
ASN90 ASN120290,
ASN-561
Progressive Supranuclear Palsy (Phase 1) Asceneuron SA Tau Small Molecule
Bepranemab UCB0107 ,
UCB 0107 ,
Antibody D
Progressive Supranuclear Palsy (Phase 1), Alzheimer's Disease (Phase 2) Hoffmann-La Roche, UCB S.A. Tau Immunotherapy (passive)
BIIB076 NI-105,
6C5 huIgG1/l
Alzheimer's Disease (Discontinued) Biogen, Eisai Co., Ltd., Neurimmune Tau Immunotherapy (passive)
BIIB080 IONIS-MAPTRx,
ISIS 814907
Alzheimer's Disease (Phase 1) Biogen, IONIS Pharmaceuticals Tau DNA/RNA-based
BIIB113 Alzheimer's Disease (Phase 1) Biogen Tau Small Molecule
BMS-986446 PRX005 Alzheimer's Disease (Phase 1) Bristol-Myers Squibb, Prothena Tau Immunotherapy (passive)
Dasatinib + Quercetin Alzheimer's Disease (Phase 1/2) Tau, Other Combination, Small Molecule, Supplement, Dietary
Davunetide NAP,
AL-108
Mild Cognitive Impairment (Discontinued), Progressive Supranuclear Palsy (Discontinued), Schizophrenia (Discontinued), Frontotemporal Dementia (Inactive) Allon Therapeutics Inc., Paladin Labs Inc. Tau Other
E2814 Alzheimer's Disease (Phase 1/2) Eisai Co., Ltd. Tau Immunotherapy (passive)
Efavirenz Efavirenz Alzheimer's Disease (Phase 1) Amyloid-Related, Tau, Cholesterol Small Molecule HIV infection
Emrusolmin Anle138b,
TEV-56286
Parkinson's Disease (Phase 1/2) MODAG GmbH, Teva Tau, alpha-synuclein, Other Small Molecule
Epothilone D BMS-241027 Alzheimer's Disease (Discontinued) Bristol-Myers Squibb Tau Small Molecule
Ezeprogind AZP2006 ,
AZP-2006
Progressive Supranuclear Palsy (Phase 2) AlzProtect Tau, Inflammation, Other Small Molecule
Gosuranemab BIIB092,
BMS-986168, IPN007
Progressive Supranuclear Palsy (Discontinued), Alzheimer's Disease (Discontinued) Biogen, Bristol-Myers Squibb Tau Immunotherapy (passive)
HMTM LMTM,
LMTX, LMT-X,
TRx0237,
Tau aggregation inhibitor (TAI),
Methylene Blue
Alzheimer's Disease (Phase 3), Frontotemporal Dementia (Phase 3) TauRx Therapeutics Ltd Tau Small Molecule Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
JNJ-63733657 Mild AD (Phase 2) Janssen Tau Immunotherapy (passive)
Lu AF87908 hC10.2 Alzheimer's Disease (Phase 1) Lundbeck Tau Immunotherapy (passive)
LY3372689 Alzheimer's Disease (Phase 2) Eli Lilly & Co. Tau Small Molecule
MK-2214 Alzheimer's Disease (Phase 1) Merck Tau Immunotherapy (passive)
NIO752 Progressive Supranuclear Palsy (Phase 1), Alzheimer's Disease (Phase 1) Novartis Pharmaceuticals Corporation Tau DNA/RNA-based
OLX-07010 Alzheimer's Disease (Phase 1) Oligomerix, Inc. Tau Small Molecule
PNT001 Alzheimer's Disease (Phase 1), Traumatic Brain Injury (Phase 1) Pinteon Therapeutics Tau Immunotherapy (passive)
Rember TM Methylene Blue ,
methylthioninium (MT),
TRx-0014,
Tau aggregation inhibitor (TAI)
Alzheimer's Disease (Discontinued) TauRx Therapeutics Ltd Tau Small Molecule Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
RG7345 RO6926496 Alzheimer's Disease (Discontinued) Tau Immunotherapy (passive)
Semorinemab RO7105705 ,
MTAU9937A,
RG6100
Alzheimer's Disease (Phase 2) AC Immune SA, Genentech, Hoffmann-La Roche Tau Immunotherapy (passive)
Tideglusib NP031112,
Nypta® ,
Zentylor™ ,
Glycogen synthase kinase 3 inhibitor,
NP12
Alzheimer's Disease (Discontinued), Progressive Supranuclear Palsy (Discontinued) Zeltia Group Tau Small Molecule
Tilavonemab ABBV-8E12,
C2N 8E12,
HJ8.5
Progressive Supranuclear Palsy (Discontinued), Alzheimer's Disease (Discontinued) AbbVie, C2N Diagnostics, LLC Tau Immunotherapy (passive)
TPI 287 Alzheimer's Disease (Inactive), Corticobasal Degeneration (Inactive), Progressive Supranuclear Palsy (Phase 1) Cortice Biosciences Tau Small Molecule
Zagotenemab LY3303560 Alzheimer's Disease (Discontinued) Eli Lilly & Co. Tau, Unknown Immunotherapy (passive)