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Name Synonyms FDA Status Company Target Type Therapy Type Approved
AMX0035 Amyotrophic Lateral Sclerosis (Phase 2), Alzheimer's Disease (Phase 2) Amylyx Pharmaceuticals Inc Other Combination, Small Molecule
Acitretin Soriatane ,
RO 101670
Alzheimer's Disease (Phase 2) Actavis, Allergan plc Amyloid-Related Small Molecule Psoriasis in US
BI 425809 Alzheimer's Disease (Phase 2), Schizophrenia (Phase 2) Boehringer Ingelheim Other Neurotransmitters Small Molecule
Bexarotene Targretin® Alzheimer's Disease (Phase 2) Ligand Pharmaceuticals, Inc., ReXceptor Inc. Amyloid-Related, Unknown Small Molecule Cutaneous T-cell Lymphoma in US
Blarcamesine Anavex2-73 Alzheimer's Disease (Phase 2) Anavex Life Science Corp. Other Small Molecule
Circadin Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Small Molecule Insomnia
Dexpramipexole R-pramipexole,
KNS-760704 ,
BIIB 050
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) Biogen, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule
EHT 0202 Etazolate Alzheimer's Disease (Phase 2) ExonHit Therapeutics Other Small Molecule None
EVP-0962 EVP 0015962 Alzheimer's Disease (Phase 2), Mild Cognitive Impairment (Phase 2) FORUM Pharmaceuticals Inc. Amyloid-Related Small Molecule
Elayta CT1812 Alzheimer's Disease (Phase 2) Cognition Therapeutics Inc. Amyloid-Related Small Molecule
G-CSF Filgrastim Alzheimer's Disease (Phase 2) Other Small Molecule Neutropenia in US
LM11A-31-BHS LM11A-31 Alzheimer's Disease (Phase 2) PharmatrophiX Other Small Molecule
Lemborexant E2006 Alzheimer's Disease (Phase 2) Eisai Co., Ltd. Other Small Molecule
Liraglutide Victoza™ Alzheimer's Disease (Phase 2) Novo Nordisk A/S Other Small Molecule
MSDC-0160 Mitoglitazone Alzheimer's Disease (Phase 2) Metabolic Solutions Development Company Other Small Molecule
Masupirdine SUVN-502 Alzheimer's Disease (Phase 2) Suven Life Sciences Ltd Other Neurotransmitters Small Molecule
Montelukast Singulair, MK0476 Alzheimer's Disease (Phase 2) Intelgenx Inflammation Small Molecule Asthma
NIC5-15 Pinitol,
Alzheimer's Disease (Phase 2) Humanetics Pharmaceuticals Corporation Amyloid-Related, Other Small Molecule, Supplement, Dietary
Nasal Insulin Detemir,
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) Amyloid-Related, Other Small Molecule, Other Diabetes
Neflamapimod VX-745 Alzheimer's Disease (Phase 2) EIP Pharma, LLC Inflammation Small Molecule
Nicotinamide Enduramide,
Nicotinic acid amide,
Vitamin B3
Alzheimer's Disease (Phase 2) Other Small Molecule
ORM-12741 Alzheimer's Disease (Phase 2) Orion Pharma Other Neurotransmitters Small Molecule
PBT2 PBT-2 Alzheimer's Disease (Phase 2), Huntington's Disease (Phase 2) Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule
PQ912 Alzheimer's Disease (Phase 2) Probiodrug AG Amyloid-Related, Inflammation Small Molecule
PTI-125 Alzheimer's Disease (Phase 2) Cassava Sciences Amyloid-Related Small Molecule
PXT864 PXT00864 Alzheimer's Disease (Phase 2) Pharnext Other Neurotransmitters Combination, Small Molecule
Pimavanserin Nuplazid,
Pimavanserin tartrate
Alzheimer's Disease (Phase 2), Schizophrenia (Phase 3), Dementia (Phase 3) Acadia Pharmaceuticals Other Neurotransmitters Small Molecule Parkinson's psychosis
Piromelatine Neu-P11 Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Neurotransmitters, Other Small Molecule
Rasagiline Rasagiline mesylate,
Alzheimer's Disease (Phase 2), Parkinson's Disease (Approved), Amyotrophic Lateral Sclerosis (Inactive) Teva Other Neurotransmitters Small Molecule
Rilapladib SB-659032 Alzheimer's Disease (Phase 2) GlaxoSmithKline (GSK) Other Small Molecule
Riluzole Rilutek®,
RP 54274
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule Amyotrophic Lateral Sclerosis in many countries
SAR110894D Alzheimer's Disease (Phase 2) Sanofi Other Small Molecule
T3D-959 DB959 Alzheimer's Disease (Phase 2) T3D Therapeutics, Inc. Other Small Molecule
Telmisartan Micardis Alzheimer's Disease (Phase 2) Boehringer Ingelheim Other Small Molecule Hypertension
XanamemTM UE 2343 Alzheimer's Disease (Phase 2) Actinogen Medical Other Small Molecule