Therapeutics
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| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
|---|---|---|---|---|---|---|
| Acitretin | Soriatane , Neotigason, RO 101670 |
Alzheimer's Disease (Phase 2) | Actavis, Allergan plc | Amyloid-Related | Small Molecule | Psoriasis in US |
| Anavex 2-73 | Alzheimer's Disease (Phase 2) | Anavex Life Science Corp. | Other | Small Molecule | ||
| BI 425809 | Alzheimer's Disease (Phase 2), Schizophrenia (Phase 2) | Boehringer Ingelheim | Other Neurotransmitters | Small Molecule | ||
| Bexarotene | Targretin® | Alzheimer's Disease (Phase 2) | Ligand Pharmaceuticals, Inc., ReXceptor Inc. | Amyloid-Related, Unknown | Small Molecule | Cutaneous T-cell Lymphoma in US |
| Circadin | Alzheimer's Disease (Phase 2) | Neurim Pharmaceuticals Ltd. | Other | Small Molecule | Insomnia | |
| Dexpramipexole | R-pramipexole, RPPX, KNS-760704 , BIIB 050 |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) | Biogen, Knopp Biosciences LLC, Virginia Commonwealth University | Other Neurotransmitters, Other | Small Molecule | |
| EHT 0202 | Etazolate | Alzheimer's Disease (Phase 2) | ExonHit Therapeutics | Other | Small Molecule | None |
| ELND005 | AZD-103, Scyllo-inositol, cyclohexane-1,2,3,4,5,6-hexol |
Alzheimer's Disease (Phase 2) | Elan Corporation, Speranza Therapeutics, Transition Therapeutics, Inc. | Amyloid-Related | Small Molecule | None |
| EVP-0962 | EVP 0015962 | Alzheimer's Disease (Phase 2), Mild Cognitive Impairment (Phase 2) | FORUM Pharmaceuticals Inc. | Amyloid-Related | Small Molecule | |
| Edonerpic | T-817 MA, T 817 | Alzheimer's Disease (Phase 2) | Toyama Chemical Co., Ltd. | Other, Unknown | Small Molecule | |
| Elayta | CT1812 | Alzheimer's Disease (Phase 2) | Cognition Therapeutics Inc. | Amyloid-Related | Small Molecule | |
| Exendin-4 | Exenatide, Byetta, Bydureon |
Alzheimer's Disease (Phase 2) | Other | Small Molecule | Diabetes mellitus in US | |
| G-CSF | Filgrastim | Alzheimer's Disease (Phase 2) | Other | Small Molecule | Neutropenia in US | |
| Liraglutide | Victoza™ | Alzheimer's Disease (Phase 2) | Novo Nordisk A/S | Other | Small Molecule | |
| MSDC-0160 | Mitoglitazone | Alzheimer's Disease (Phase 2) | Metabolic Solutions Development Company | Other | Small Molecule | |
| Minocycline | Solodyn, Arestin, Minocin, Dynacin |
Alzheimer's Disease (Phase 2) | Inflammation | Small Molecule | ||
| NIC5-15 | Pinitol, D-Pinitol |
Alzheimer's Disease (Phase 2) | Humanetics Pharmaceuticals Corporation | Amyloid-Related, Other | Small Molecule, Dietary Supplement | |
| Nasal Insulin | Detemir, Levemir, Humulin, Novolin |
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) | Amyloid-Related, Other | Small Molecule, Other | Diabetes | |
| Neflamapimod | VX-745 | Alzheimer's Disease (Phase 2) | EIP Pharma, LLC | Inflammation | Small Molecule | |
| Nicotinamide | Enduramide, Niacinamide, Nicotinic acid amide, Vitamin B3 |
Alzheimer's Disease (Phase 2) | Other | Small Molecule | ||
| ORM-12741 | Alzheimer's Disease (Phase 2) | Orion Pharma | Other Neurotransmitters | Small Molecule | ||
| PBT2 | PBT-2 | Alzheimer's Disease (Phase 2), Huntington's Disease (Phase 2) | Prana Biotechnology Limited | Amyloid-Related, Metals | Small Molecule | |
| PQ912 | Alzheimer's Disease (Phase 2) | Probiodrug AG | Amyloid-Related, Inflammation | Small Molecule | ||
| PXT864 | PXT00864 | Alzheimer's Disease (Phase 2) | Pharnext | Other Neurotransmitters | Small Molecule | |
| Pimavanserin | Nuplazid, ACP-103, Pimavanserin tartrate |
Alzheimer's Disease (Phase 2), Schizophrenia (Phase 3) | Acadia Pharmaceuticals | Other Neurotransmitters | Small Molecule | Parkinson's psychosis |
| Piromelatine | Neu-P11 | Alzheimer's Disease (Phase 2) | Neurim Pharmaceuticals Ltd. | Other Neurotransmitters, Other | Small Molecule | |
| Rilapladib | SB-659032 | Alzheimer's Disease (Phase 2) | GlaxoSmithKline (GSK) | Other | Small Molecule | |
| Riluzole | Rilutek®, RP 54274 |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) | Sanofi | Other Neurotransmitters, Other | Small Molecule | Amyotrophic Lateral Sclerosis in many countries |
| SAR110894D | Alzheimer's Disease (Phase 2) | Sanofi | Other | Small Molecule | ||
| SUVN-502 | Alzheimer's Disease (Phase 2) | Suven Life Sciences Ltd | Other Neurotransmitters | Small Molecule | ||
| Saracatinib | AZD0530 | Alzheimer's Disease (Phase 2) | AstraZeneca | Other | Small Molecule | |
| T3D-959 | DB959 | Alzheimer's Disease (Phase 2) | T3D Therapeutics, Inc. | Other | Small Molecule | |
| Telmisartan | Micardis | Alzheimer's Disease (Phase 2) | Boehringer Ingelheim | Other | Small Molecule | Hypertension |
| XanamemTM | UE 2343 | Alzheimer's Disease (Phase 2) | Actinogen Medical | Other | Small Molecule |