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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
AMX0035 Amyotrophic Lateral Sclerosis (Phase 2), Alzheimer's Disease (Phase 2) Amylyx Pharmaceuticals Inc Other Combination, Small Molecule
ATH-1017 NDX-1017 Alzheimer's Disease (Phase 2) Athira Pharma Other Small Molecule
Acitretin Soriatane ,
Neotigason,
RO 101670
Alzheimer's Disease (Phase 2) Actavis, Allergan plc Amyloid-Related Small Molecule Psoriasis in US
BPN14770 Alzheimer's Disease (Phase 2) Shionogi Pharma, Tetra Therapeutics Cholinergic System, Other Small Molecule
Bexarotene Targretin® Alzheimer's Disease (Phase 2) Ligand Pharmaceuticals, Inc., ReXceptor Inc. Amyloid-Related, Unknown Small Molecule Cutaneous T-cell Lymphoma in US
Bosutinib BOSULIF®,
PF-5208763,
SKI-606
Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) Pfizer Other Small Molecule Chronic myeloid leukemia
Candesartan Atacand,
Candesartan cilexetil
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Phase 2) AstraZeneca, Takeda Pharmaceutical Company Other Small Molecule Hypertension, congestive heart failure
Circadin Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Small Molecule Insomnia
DAYVIGO Lemborexant,
E2006
Alzheimer's Disease (Phase 2) Eisai Co., Ltd. Other Small Molecule Insomnia
Deferiprone Ferriprox Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2/3), Amyotrophic Lateral Sclerosis (Phase 2) Apotex Inc., Chiesi Pharmaceuticals Inc. Metals Small Molecule Iron overload due to thalassemia syndromes
Dexpramipexole R-pramipexole,
RPPX,
KNS-760704 ,
BIIB 050
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) Biogen, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule
EHT 0202 Etazolate Alzheimer's Disease (Phase 2) ExonHit Therapeutics Other Small Molecule None
Elayta CT1812 Alzheimer's Disease (Phase 2) Cognition Therapeutics Inc. Amyloid-Related Small Molecule
G-CSF Filgrastim Alzheimer's Disease (Phase 2) Other Small Molecule Neutropenia in US
LM11A-31-BHS LM11A-31 Alzheimer's Disease (Phase 2) PharmatrophiX Other Small Molecule
Losartan Cozaar®,
MK0954
Alzheimer's Disease (Phase 2) Merck Other Small Molecule Hypertension, diabetic neuropathy
MSDC-0160 Mitoglitazone Alzheimer's Disease (Phase 2) Metabolic Solutions Development Company Other Small Molecule
Masupirdine SUVN-502 Alzheimer's Disease (Phase 2) Suven Life Sciences Ltd Other Neurotransmitters Small Molecule
Montelukast Singulair, MK0476 Alzheimer's Disease (Phase 2) Intelgenx Inflammation Small Molecule Asthma
NIC5-15 Pinitol,
D-Pinitol
Alzheimer's Disease (Phase 2) Humanetics Pharmaceuticals Corporation Amyloid-Related, Other Small Molecule, Supplement, Dietary
Nasal Insulin Detemir,
Levemir,
Humulin,
Novolin
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) Amyloid-Related, Other Small Molecule, Other Diabetes
Neflamapimod VX-745 Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Huntington's Disease (Phase 2) EIP Pharma, LLC Inflammation Small Molecule
Nicotinamide Enduramide,
Niacinamide,
Nicotinic acid amide,
Vitamin B3
Alzheimer's Disease (Phase 2) Other Small Molecule
Nilotinib Tasigna,
AMN107
Parkinson's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Alzheimer's Disease (Phase 2) Novartis Pharmaceuticals Corporation Other Small Molecule Chronic myeloid leukemia
ORM-12741 Alzheimer's Disease (Phase 2) Orion Pharma Other Neurotransmitters Small Molecule
PBT2 PBT-2 Alzheimer's Disease (Phase 2), Huntington's Disease (Phase 2) Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule
PXT864 PXT00864 Alzheimer's Disease (Phase 2) Pharnext Other Neurotransmitters Combination, Small Molecule
Piromelatine Neu-P11 Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Neurotransmitters, Other Small Molecule
Posiphen ANVS-401,
(+)-phenserine,
Posiphen tartrate
Alzheimer's Disease (Phase 2) Annovis Bio Amyloid-Related, alpha-synuclein Small Molecule
Rasagiline Rasagiline mesylate,
Azilect,
TVP-1012
Alzheimer's Disease (Phase 2), Parkinson's Disease (Approved), Amyotrophic Lateral Sclerosis (Inactive) Teva Other Neurotransmitters Small Molecule
Rilapladib SB-659032 Alzheimer's Disease (Phase 2) GlaxoSmithKline (GSK) Other Small Molecule
Riluzole Rilutek®,
RP 54274
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule Amyotrophic Lateral Sclerosis in many countries
Rotigotine Neupro Alzheimer's Disease (Phase 2) UCB S.A. Other Neurotransmitters Small Molecule Parkinson's disease, Restless Leg Syndrome
SAR110894D Alzheimer's Disease (Phase 2) Sanofi Other Small Molecule
Sumifilam PTI-125 Alzheimer's Disease (Phase 2) Cassava Sciences Amyloid-Related Small Molecule
T3D-959 DB959 Alzheimer's Disease (Phase 2) T3D Therapeutics, Inc. Other Small Molecule
Telmisartan Micardis Alzheimer's Disease (Phase 2) Boehringer Ingelheim Other Small Molecule Hypertension
Vafidemstat ORY-2001 Alzheimer's Disease (Phase 2) Oryzon Corporate Other Neurotransmitters Small Molecule
Valacyclovir Valtrex,
Valaciclovir,
256U87
Alzheimer's Disease (Phase 2) GlaxoSmithKline (GSK) Other Small Molecule Herpes virus outbreaks
Varoglutamstat PQ912 Alzheimer's Disease (Phase 2) Probiodrug AG, Vivoryon Therapeutics N.V. Amyloid-Related, Inflammation Small Molecule
Xanamem UE 2343 Alzheimer's Disease (Phase 2) Actinogen Medical Other Small Molecule