Therapeutics
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| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
|---|---|---|---|---|---|---|
| AMX0035 | Amyotrophic Lateral Sclerosis (Phase 2), Alzheimer's Disease (Phase 2) | Amylyx Pharmaceuticals Inc | Other | Combination, Small Molecule | ||
| ATH-1017 | NDX-1017 | Alzheimer's Disease (Phase 2) | Athira Pharma | Other | Small Molecule | |
| Acitretin | Soriatane , Neotigason, RO 101670 |
Alzheimer's Disease (Phase 2) | Actavis, Allergan plc | Amyloid-Related | Small Molecule | Psoriasis in US |
| BPN14770 | Alzheimer's Disease (Phase 2) | Shionogi Pharma, Tetra Therapeutics | Cholinergic System, Other | Small Molecule | ||
| Bexarotene | Targretin® | Alzheimer's Disease (Phase 2) | Ligand Pharmaceuticals, Inc., ReXceptor Inc. | Amyloid-Related, Unknown | Small Molecule | Cutaneous T-cell Lymphoma in US |
| Bosutinib | BOSULIF®, PF-5208763, SKI-606 |
Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) | Pfizer | Other | Small Molecule | Chronic myeloid leukemia |
| Candesartan | Atacand, Candesartan cilexetil |
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Phase 2) | AstraZeneca, Takeda Pharmaceutical Company | Other | Small Molecule | Hypertension, congestive heart failure |
| Circadin | Alzheimer's Disease (Phase 2) | Neurim Pharmaceuticals Ltd. | Other | Small Molecule | Insomnia | |
| DAYVIGO | Lemborexant, E2006 |
Alzheimer's Disease (Phase 2) | Eisai Co., Ltd. | Other | Small Molecule | Insomnia |
| Deferiprone | Ferriprox | Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2/3), Amyotrophic Lateral Sclerosis (Phase 2) | Apotex Inc., Chiesi Pharmaceuticals Inc. | Metals | Small Molecule | Iron overload due to thalassemia syndromes |
| Dexpramipexole | R-pramipexole, RPPX, KNS-760704 , BIIB 050 |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) | Biogen, Knopp Biosciences LLC, Virginia Commonwealth University | Other Neurotransmitters, Other | Small Molecule | |
| EHT 0202 | Etazolate | Alzheimer's Disease (Phase 2) | ExonHit Therapeutics | Other | Small Molecule | None |
| Elayta | CT1812 | Alzheimer's Disease (Phase 2) | Cognition Therapeutics Inc. | Amyloid-Related | Small Molecule | |
| G-CSF | Filgrastim | Alzheimer's Disease (Phase 2) | Other | Small Molecule | Neutropenia in US | |
| LM11A-31-BHS | LM11A-31 | Alzheimer's Disease (Phase 2) | PharmatrophiX | Other | Small Molecule | |
| Losartan | Cozaar®, MK0954 |
Alzheimer's Disease (Phase 2) | Merck | Other | Small Molecule | Hypertension, diabetic neuropathy |
| MSDC-0160 | Mitoglitazone | Alzheimer's Disease (Phase 2) | Metabolic Solutions Development Company | Other | Small Molecule | |
| Masupirdine | SUVN-502 | Alzheimer's Disease (Phase 2) | Suven Life Sciences Ltd | Other Neurotransmitters | Small Molecule | |
| Montelukast | Singulair, MK0476 | Alzheimer's Disease (Phase 2) | Intelgenx | Inflammation | Small Molecule | Asthma |
| NIC5-15 | Pinitol, D-Pinitol |
Alzheimer's Disease (Phase 2) | Humanetics Pharmaceuticals Corporation | Amyloid-Related, Other | Small Molecule, Supplement, Dietary | |
| Nasal Insulin | Detemir, Levemir, Humulin, Novolin |
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) | Amyloid-Related, Other | Small Molecule, Other | Diabetes | |
| Neflamapimod | VX-745 | Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Huntington's Disease (Phase 2) | EIP Pharma, LLC | Inflammation | Small Molecule | |
| Nicotinamide | Enduramide, Niacinamide, Nicotinic acid amide, Vitamin B3 |
Alzheimer's Disease (Phase 2) | Other | Small Molecule | ||
| Nilotinib | Tasigna, AMN107 |
Parkinson's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Alzheimer's Disease (Phase 2) | Novartis Pharmaceuticals Corporation | Other | Small Molecule | Chronic myeloid leukemia |
| ORM-12741 | Alzheimer's Disease (Phase 2) | Orion Pharma | Other Neurotransmitters | Small Molecule | ||
| PBT2 | PBT-2 | Alzheimer's Disease (Phase 2), Huntington's Disease (Phase 2) | Prana Biotechnology Limited | Amyloid-Related, Metals | Small Molecule | |
| PXT864 | PXT00864 | Alzheimer's Disease (Phase 2) | Pharnext | Other Neurotransmitters | Combination, Small Molecule | |
| Piromelatine | Neu-P11 | Alzheimer's Disease (Phase 2) | Neurim Pharmaceuticals Ltd. | Other Neurotransmitters, Other | Small Molecule | |
| Posiphen | ANVS-401, (+)-phenserine, Posiphen tartrate |
Alzheimer's Disease (Phase 2) | Annovis Bio | Amyloid-Related, alpha-synuclein | Small Molecule | |
| Rasagiline | Rasagiline mesylate, Azilect, TVP-1012 |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Approved), Amyotrophic Lateral Sclerosis (Inactive) | Teva | Other Neurotransmitters | Small Molecule | |
| Rilapladib | SB-659032 | Alzheimer's Disease (Phase 2) | GlaxoSmithKline (GSK) | Other | Small Molecule | |
| Riluzole | Rilutek®, RP 54274 |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) | Sanofi | Other Neurotransmitters, Other | Small Molecule | Amyotrophic Lateral Sclerosis in many countries |
| Rotigotine | Neupro | Alzheimer's Disease (Phase 2) | UCB S.A. | Other Neurotransmitters | Small Molecule | Parkinson's disease, Restless Leg Syndrome |
| SAR110894D | Alzheimer's Disease (Phase 2) | Sanofi | Other | Small Molecule | ||
| Sumifilam | PTI-125 | Alzheimer's Disease (Phase 2) | Cassava Sciences | Amyloid-Related | Small Molecule | |
| T3D-959 | DB959 | Alzheimer's Disease (Phase 2) | T3D Therapeutics, Inc. | Other | Small Molecule | |
| Telmisartan | Micardis | Alzheimer's Disease (Phase 2) | Boehringer Ingelheim | Other | Small Molecule | Hypertension |
| Vafidemstat | ORY-2001 | Alzheimer's Disease (Phase 2) | Oryzon Corporate | Other Neurotransmitters | Small Molecule | |
| Valacyclovir | Valtrex, Valaciclovir, 256U87 |
Alzheimer's Disease (Phase 2) | GlaxoSmithKline (GSK) | Other | Small Molecule | Herpes virus outbreaks |
| Varoglutamstat | PQ912 | Alzheimer's Disease (Phase 2) | Probiodrug AG, Vivoryon Therapeutics N.V. | Amyloid-Related, Inflammation | Small Molecule | |
| Xanamem | UE 2343 | Alzheimer's Disease (Phase 2) | Actinogen Medical | Other | Small Molecule |