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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
Dexpramipexole R-pramipexole,
RPPX,
KNS-760704 ,
BIIB 050
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) Biogen, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule
Masupirdine SUVN-502 Alzheimer's Disease (Phase 2) Suven Life Sciences Ltd Other Neurotransmitters Small Molecule
ORM-12741 Alzheimer's Disease (Phase 2) Orion Pharma Other Neurotransmitters Small Molecule
PXT864 PXT00864 Alzheimer's Disease (Phase 2) Pharnext Other Neurotransmitters Combination, Small Molecule
Piromelatine Neu-P11 Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Neurotransmitters, Other Small Molecule
Rasagiline Rasagiline mesylate,
Azilect,
TVP-1012
Alzheimer's Disease (Phase 2), Parkinson's Disease (Approved), Amyotrophic Lateral Sclerosis (Inactive) Teva Other Neurotransmitters Small Molecule
Riluzole Rilutek®,
RP 54274
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule Amyotrophic Lateral Sclerosis in many countries
Rotigotine Neupro Alzheimer's Disease (Phase 2) UCB S.A. Other Neurotransmitters Small Molecule Parkinson's disease, Restless Leg Syndrome
Vafidemstat ORY-2001 Alzheimer's Disease (Phase 2) Oryzon Corporate Other Neurotransmitters Small Molecule