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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
ALZ-801 NRM-8499, homotaurine, 3-APS Alzheimer's Disease (Phase 3) Alzheon Inc. Amyloid-Related Small Molecule
ALZT-OP1 Cromolyn sodium, Intal,
Ibuprofen
Alzheimer's Disease (Phase 3) AZTherapies, Inc. Amyloid-Related, Inflammation Combination, Small Molecule
AVP-786 Alzheimer's Disease (Phase 3), Schizophrenia (Phase 2) Avanir Pharmaceuticals, Concert Pharmaceuticals, Inc., Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Combination, Small Molecule
Alpha-Tocopherol Vitamin E Alzheimer's Disease (Phase 3) Other Supplement, Dietary
Aripiprazole Abilify,
BMS-337039
Alzheimer's Disease (Phase 3), Schizophrenia (Approved) Bristol-Myers Squibb, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
Brexpiprazole Rexulti,
OPC 34712
Alzheimer's Disease (Phase 3), Schizophrenia (Approved) H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
Citalopram escitalopram,
Celexa,
Lexapro ,
Cipralex
Alzheimer's Disease (Phase 3), Preclinical Alzheimer's Disease (Inactive) Other Neurotransmitters Small Molecule Depression, generalized anxiety disorder
Continuous Positive Airway Pressure CPAP Alzheimer's Disease (Phase 3) Unknown Procedural Intervention Sleep Apnea in US
Donanemab N3pG-Aβ Monoclonal Antibody,
LY3002813
Alzheimer's Disease (Phase 3) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
GV-971 sodium oligomannate,
sodium oligo-mannurarate
Alzheimer's Disease (Phase 3) Shanghai Green Valley Pharmaceuticals Amyloid-Related, Inflammation Small Molecule
Gantenerumab RO4909832,
RG1450
Alzheimer's Disease (Phase 3) Chugai Pharmaceutical Co., Ltd., Hoffmann-La Roche Amyloid-Related Immunotherapy (passive)
Guanfacine Intuniv,
SPD503,
Afken,
Estulic,
Tenex
Alzheimer's Disease (Phase 3) Other Neurotransmitters Small Molecule Attention-deficit hyperactivity disorder, hypertension
LMTM TRx0237, LMT-X,
Methylene Blue,
Tau aggregation inhibitor (TAI)
Alzheimer's Disease (Phase 3), Frontotemporal Dementia (Phase 3) TauRx Therapeutics Ltd Tau Small Molecule Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
Lecanemab BAN2401 ,
mAb158
Alzheimer's Disease (Phase 3) Biogen, Eisai Co., Ltd. Amyloid-Related Immunotherapy (passive)
Levetiracetam Keppra Alzheimer's Disease (Phase 3), Parkinson's Disease (Discontinued) UCB S.A. Amyloid-Related, Other Small Molecule Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries
Lumateperone ITI-007 Alzheimer's Disease (Phase 3), Schizophrenia (Phase 3), Bipolar Disorder (Phase 3) Bristol-Myers Squibb, Intra-Cellular Therapies, Inc. Other Neurotransmitters Small Molecule
Masitinib Masivet,
Kinavet,
AB1010,
Masitinib mesylate
Alzheimer's Disease (Phase 3), Amyotrophic Lateral Sclerosis (Phase 3) AB Science Other Small Molecule
Pimavanserin Nuplazid,
ACP-103,
Pimavanserin tartrate
Alzheimer's Disease (Phase 3), Schizophrenia (Phase 3), Dementia (Phase 3), Depression (Discontinued) Acadia Pharmaceuticals Other Neurotransmitters Small Molecule Parkinson's psychosis
Pioglitazone AD4833,
Actos®,
Glustin™,
Piozone®
Mild Cognitive Impairment (Phase 3) Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. Inflammation, Other Small Molecule Type 2 diabetes mellitus
Semaglutide Ozempic,
Rybelsus
Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 2) Novo Nordisk A/S Other Other Type 2 Diabetes
Solanezumab LY2062430 Alzheimer's Disease (Phase 3) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive) None
UB-311 Alzheimer's Disease (Phase 3) United Neuroscience Amyloid-Related Immunotherapy (active)