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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
AAB-003 PF-05236812 Alzheimer's Disease (Discontinued) Janssen, Pfizer Amyloid-Related Immunotherapy (passive)
AADvac1 Axon peptide 108 conjugated to KLH Alzheimer's Disease (Phase 2), Progressive Nonfluent Aphasia (Phase 1) Axon Neuroscience SE Tau Immunotherapy (active)
AAV-GAD AAV-GAD2,
NLX-P101
Parkinson's Disease (Phase 1/2) MeiraGTx Limited Other Neurotransmitters DNA/RNA-based
AAV2-BDNF MCI due to AD (Phase 1), Alzheimer's Disease (Phase 1) Other DNA/RNA-based
ABBV-0805 BAN0805 Parkinson's Disease (Inactive) AbbVie, BioArctic AB alpha-synuclein Immunotherapy (passive)
ABBV-552 Alzheimer's Disease (Phase 1) AbbVie Other Small Molecule
ABBV-916 N3pG-Abeta mAb Alzheimer's Disease (Phase 2) Amyloid-Related Immunotherapy (passive)
ABBV-CLS-7262 Amyotrophic Lateral Sclerosis (Phase 1) Other Small Molecule
ABT-089 Alzheimer's Disease (Discontinued) Abbott Laboratories Cholinergic System Small Molecule
ABT-288 Alzheimer's Disease (Discontinued) AbbVie Cholinergic System, Other Neurotransmitters Small Molecule
ABT-384 Alzheimer's Disease (Discontinued) AbbVie Other Small Molecule
ABT-957 Alicapistat Alzheimer's Disease (Discontinued) AbbVie Other Small Molecule
ABT 418 Alzheimer's Disease (Discontinued) Cholinergic System Small Molecule None
ABvac40 Alzheimer's Disease (Phase 2) Araclon Biotech Amyloid-Related Immunotherapy (active)
ACD856 Alzheimer's Disease (Phase 1) AlzeCure Pharma AB Other Small Molecule
Acetyl-l-carnitine HCI ALCAR Alzheimer's Disease (Discontinued) Sigma-Tau Pharmaceuticals Other Supplement, Dietary
ACI-24 ACI-24.060,
Pal1-15 acetate salt
Alzheimer's Disease (Phase 2), Down's Syndrome (Phase 2) AC Immune SA Amyloid-Related Immunotherapy (active)
ACI-35 VAC20121,
JNJ-64042056
Alzheimer's Disease (Phase 2/3) AC Immune SA, Janssen Tau Immunotherapy (active)
ACI-3024 Tau MorphomerTM Alzheimer's Disease (Inactive), Other Tauopathy (Phase 0) AC Immune SA Tau Small Molecule
ACI-7104.056 ACI-7104,
Affitope PD01A,
PD03A
Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 1) AC Immune SA, AFFiRiS AG alpha-synuclein Immunotherapy (active)
Acitretin Soriatane ,
Neotigason,
RO 101670
Alzheimer's Disease (Phase 2) Actavis, Allergan plc Amyloid-Related Small Molecule Psoriasis in US
ACP-204 Alzheimer's Disease (Phase 2/3) Acadia Pharmaceuticals Other Neurotransmitters Small Molecule
ACU193 ACU-193 Alzheimer's Disease (Phase 1) Acumen Pharmaceuticals, Inc. Amyloid-Related Immunotherapy (passive)
Aduhelm Aducanumab,
BIIB037
Alzheimer's Disease (Approved) Biogen, Neurimmune Amyloid-Related Immunotherapy (passive)
AF 102B cevimeline HCL,
Evoxac™
Alzheimer's Disease (Discontinued) SnowBrand Pharmaceuticals, Inc. Cholinergic System Small Molecule Treatment of dry mouth in Sjogren's syndrome.
Affitope AD02 Alzheimer's Disease (Discontinued) AFFiRiS AG Amyloid-Related Immunotherapy (active)
AGB101 levetiracetam MCI-AD (Phase 2/3) AgeneBio, Inc. Amyloid-Related Small Molecule
AKST4290 ALK4290,
lazucirnon
Parkinson's Disease (Phase 2) Alkahest, Inc. Inflammation Small Molecule
AL002 Alzheimer's Disease (Phase 2) AbbVie, Alector Inflammation Immunotherapy (passive)
AL003 Alzheimer's Disease (Discontinued) AbbVie, Alector Inflammation Immunotherapy (passive)
AL044 Alzheimer's Disease (Phase 1) Alector Inflammation Immunotherapy (passive)
AL101 GSK-4527226 Alzheimer's Disease (Phase 1) Alector Other Immunotherapy (passive)
Allopregnanolone brexanolone,
3α-hydroxy-5α-pregnan-20-one,
3α,5α-tetrahydroprogesterone
Alzheimer's Disease (Phase 2) Other Neurotransmitters, Other Small Molecule
ALN-APP Alzheimer's Disease (Phase 1) Alnylam Pharmaceuticals, Inc., Regeneron Pharmaceuticals Inc. Amyloid-Related DNA/RNA-based
ALPHA-1062 GLN-1062 ,
Memogain
Alzheimer's Disease (Phase 3) Alpha Cognition, Galantos Pharma Cholinergic System Small Molecule
Alpha-Tocopherol Vitamin E Alzheimer's Disease (Phase 3) Other Supplement, Dietary
ALX-001 BMS-984923 Alzheimer's Disease (Phase 1) Allyx Therapeutics, Inc. Amyloid-Related, Other Neurotransmitters Small Molecule
ALZ-101 Alzheimer's Disease (Phase 1) Alzinova AB Amyloid-Related Immunotherapy (active)
ALZ-801 valiltramiprosate,
NRM-8499,
homotaurine prodrug,
3-APS
Alzheimer's Disease (Phase 3) Alzheon Inc. Amyloid-Related Small Molecule
Alzhemed™ Vivimind™,
Tramiprosate,
NC-531,
homotaurine,
3-APS
Alzheimer's Disease (Discontinued) Neurochem, Inc. Amyloid-Related Supplement, Dietary None
ALZT-OP1 Cromolyn sodium, Intal,
Ibuprofen
Alzheimer's Disease (Phase 3) AZTherapies, Inc. Amyloid-Related, Inflammation Combination, Small Molecule
Ambroxol Ambrosan, Mucosolvan Parkinson's Disease (Phase 2), Parkinson's Disease Dementia (Phase 2), Dementia with Lewy Bodies (Phase 2) alpha-synuclein, Other Small Molecule
Amilomotide CAD106 Alzheimer's Disease (Inactive) Novartis Pharmaceuticals Corporation Amyloid-Related Immunotherapy (active) None
AN-1792 AIP 001 Alzheimer's Disease (Discontinued) Janssen, Pfizer Amyloid-Related Immunotherapy (active) None
ANX005 Amyotrophic Lateral Sclerosis (Phase 2) Annexon, Inc. Inflammation, Other Immunotherapy (passive)
Apabetalone RVX208,
RVX000222
MCI-VaD (Phase 3) Resverlogix Corporation Other Small Molecule
APNmAb005 RAA7 Alzheimer's Disease (Phase 1) Aprinoia Therapeutics Tau Immunotherapy (passive)
AQW051 Alpha-7 nicotinic acetylcholine receptor agonist Alzheimer's Disease (Inactive), Parkinson's Disease (Phase 2), Schizophrenia (Phase 2) Novartis Pharmaceuticals Corporation Cholinergic System Small Molecule
AR1001 Alzheimer's Disease (Phase 3) Aribio Co., Ltd. Other Small Molecule
Aripiprazole Abilify,
BMS-337039
Alzheimer's Disease (Phase 3), Schizophrenia (Approved) Bristol-Myers Squibb, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
ASN51 ASN121151 Alzheimer's Disease (Phase 1) Asceneuron SA Tau Small Molecule
ASN90 ASN120290,
ASN-561
Progressive Supranuclear Palsy (Phase 1) Asceneuron SA Tau Small Molecule
Atabecestat JNJ-54861911 ,
BACE inhibitor
Alzheimer's Disease (Discontinued) Janssen, Shionogi Pharma Amyloid-Related Small Molecule
Atomoxetine ATX,
Strattera
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1) Eli Lilly & Co. Other Neurotransmitters Small Molecule ADHD in US
Atorvastatin Lipitor™ ,
Zarator®,
Sortis®,
Tahor®
Alzheimer's Disease (Inactive) Pfizer Cholesterol Small Molecule Hypercholesterolaemia
Atuzaginstat COR388 Alzheimer's Disease (Discontinued) Cortexyme, Inc., Quince Therapeutics Other Small Molecule
AV-1959D AV-1959 Alzheimer's Disease (Phase 1) Amyloid-Related Immunotherapy (active)
Avagacestat BMS-708163 Alzheimer's Disease (Discontinued) Bristol-Myers Squibb Amyloid-Related Small Molecule
AVP-786 Alzheimer's Disease (Phase 3), Schizophrenia (Phase 2) Avanir Pharmaceuticals, Concert Pharmaceuticals, Inc., Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Combination, Small Molecule
AVP-923 Nuedexta,
Zenvia
Alzheimer's Disease (Phase 4), Amyotrophic Lateral Sclerosis (Phase 3), Parkinson's Disease (Phase 3) Avanir Pharmaceuticals, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Combination, Small Molecule
AXS-05 Dextromethorphan/bupropion,
Auvelity
Alzheimer's Disease (Phase 2/3) Axsome Therapeutics, Inc. Other Neurotransmitters Combination, Small Molecule Major depressive disorder
AZD1446 TC-6683 Alzheimer's Disease (Discontinued) AstraZeneca, Targacept Cholinergic System Small Molecule None
AZD3480 ispronicline,
TC-1734
Alzheimer's Disease (Inactive) AstraZeneca, Targacept Cholinergic System Small Molecule
Azeliragon PF-04494700,
TTP488
Alzheimer's Disease (Discontinued) Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC Amyloid-Related, Inflammation Small Molecule
Bapineuzumab AAB-001 Alzheimer's Disease (Discontinued) Janssen, Pfizer Amyloid-Related Immunotherapy (passive)
Baricitinib Olumiant®,
NCB28050,
LY3009104
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 1) Eli Lilly & Co. Inflammation Small Molecule Rheumatoid arthritis, Eczema (Europe, Japan only)
Benfotiamine S-benzoylthiamine-O-monophosphate,
Vitamin B1,
Thiamine
Alzheimer's Disease (Phase 2) Inflammation, Other Supplement, Dietary
Bepranemab UCB0107 ,
UCB 0107 ,
Antibody D
Progressive Supranuclear Palsy (Phase 1), Alzheimer's Disease (Phase 2) Hoffmann-La Roche, UCB S.A. Tau Immunotherapy (passive)
Besipirdine HCl HP 749 Alzheimer's Disease (Discontinued) Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule
Bexarotene Targretin® Alzheimer's Disease (Phase 2) Ligand Pharmaceuticals, Inc., ReXceptor Inc. Amyloid-Related, Unknown Small Molecule Cutaneous T-cell Lymphoma in US
BI 409306 SUB 166499 Alzheimer's Disease (Discontinued), Schizophrenia (Phase 2) Boehringer Ingelheim Other Neurotransmitters, Other Small Molecule
BI 1181181 VTP 37948,
BACE inhibitor
Alzheimer's Disease (Discontinued) Boehringer Ingelheim, Vitae Pharmaceuticals Amyloid-Related Small Molecule
Bifidobacterium breve A1 MCC1274,
B. breve
Mild Cognitive Impairment (Phase 2) Morinaga Milk Industry Co., Ltd Other Supplement, Dietary
BIIB076 NI-105,
6C5 huIgG1/l
Alzheimer's Disease (Discontinued) Biogen, Eisai Co., Ltd., Neurimmune Tau Immunotherapy (passive)
BIIB078 BIIB-078,
IONIS-C9Rx
Amyotrophic Lateral Sclerosis (Discontinued) Biogen, IONIS Pharmaceuticals Other DNA/RNA-based
BIIB080 IONIS-MAPTRx,
ISIS 814907
Alzheimer's Disease (Phase 1) Biogen, IONIS Pharmaceuticals Tau DNA/RNA-based
BIIB094 ION859,
IONIS-BIIB7Rx
Parkinson's Disease (Phase 1) Biogen, IONIS Pharmaceuticals Inflammation, Other DNA/RNA-based
BIIB100 KPT-350 Amyotrophic Lateral Sclerosis (Discontinued) Biogen Inflammation, Other Small Molecule
BIIB105 ION541 Amyotrophic Lateral Sclerosis (Phase 1/2) Biogen, IONIS Pharmaceuticals Other DNA/RNA-based
BIIB113 Alzheimer's Disease (Phase 1) Biogen Tau Small Molecule
BIIB118 PF-05251749 Alzheimer's Disease (Phase 1), Parkinson's Disease (Phase 1) Biogen Other Small Molecule
Blarcamesine Anavex 2-73 Alzheimer's Disease (Phase 2/3), Parkinson's Disease Dementia (Phase 2), Parkinson's Disease (Phase 1) Anavex Life Science Corp. Other Small Molecule
BMS-986446 PRX005 Alzheimer's Disease (Phase 1) Bristol-Myers Squibb, Prothena Tau Immunotherapy (passive)
Bosutinib BOSULIF®,
PF-5208763,
SKI-606
Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) Pfizer Other Small Molecule Chronic myeloid leukemia
BPN14770 Alzheimer's Disease (Phase 2) Shionogi Pharma, Tetra Therapeutics Cholinergic System, Other Small Molecule
Brexpiprazole Rexulti,
OPC 34712
Alzheimer's Disease (Approved), Schizophrenia (Approved) Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
BRT-DA01 Bemdaneprocel ,
MSK-DA01
Parkinson's Disease (Phase 1) Bayer, BlueRock Therapeutics Other Neurotransmitters, Other Other
Bryostatin 1 Alzheimer's Disease (Phase 2) Synaptogenix, Inc. Other Other
Buntanetap Posiphen,
ANVS-401,
Posiphen tartrate
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1/2) Annovis Bio Amyloid-Related, alpha-synuclein Small Molecule
Candesartan Atacand,
Candesartan cilexetil
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Phase 2) AstraZeneca, Takeda Pharmaceutical Company Other Small Molecule Hypertension, congestive heart failure
Cannabidiol CBD,
Epidiolex
Alzheimer's Disease (Phase 2) Other Neurotransmitters Small Molecule Seizures in Dravet syndrome, Lennox-Gastaut syndrome or tuberous sclerosis complex
Carvedilol Coreg,
Artist ,
Aucardic,
Dilatrend,
Kredex
Alzheimer's Disease (Phase 4) Procter & Gamble Unknown Small Molecule Hypertension, heart failure, angina pectoris
CDNF cerebral dopamine neurotrophic factor Parkinson's Disease (Phase 1/2) Herantis Pharma Plc, Renishaw plc. Other Procedural Intervention, Other
Celecoxib Celebrex Alzheimer's Disease (Discontinued) Pfizer Inflammation Small Molecule Pain, Arthritis
CERE-110 Nerve Growth Factor gene therapy Alzheimer's Disease (Discontinued) Sangamo BioSciences, Inc. Other DNA/RNA-based
Cerebrolysin Alzheimer's Disease (Phase 2) Ebewe Pharmaceutical Other Other
CHF 5074 Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. Amyloid-Related, Inflammation, Other Small Molecule
Cinpanemab BIIB054,
NI-202
Parkinson's Disease (Discontinued) Biogen, Neurimmune alpha-synuclein Immunotherapy (passive)
Circadin Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Small Molecule Insomnia
Citalopram escitalopram,
Celexa,
Lexapro ,
Cipralex
Alzheimer's Disease (Phase 3), Preclinical Alzheimer's Disease (Inactive) Other Neurotransmitters Small Molecule Depression, generalized anxiety disorder
Clioquinol iodochlorhydroxyquin,
PBT-1
Alzheimer's Disease (Discontinued) Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule
CNM-Au8 Gold nanocrystals Parkinson's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 2/3) Clene Nanomedicine, Inc. Metals, Other Other
Cocoa Flavanols Mild Cognitive Impairment (Not Regulated) Inflammation, Other Supplement, Dietary
COGNIShunt™ Alzheimer's Disease (Inactive) Other Procedural Intervention None
Continuous Positive Airway Pressure CPAP Alzheimer's Disease (Phase 3) Unknown Procedural Intervention Sleep Apnea in US
CpG 1018® CpG oligodeoxynucleotides,
CpG ODN
Alzheimer's Disease (Phase 1) Dynavax Technologies Amyloid-Related, Inflammation Immunotherapy (active), DNA/RNA-based
Crenezumab MABT5102A ,
RG7412
Alzheimer's Disease (Discontinued) AC Immune SA, Genentech, Hoffmann-La Roche Amyloid-Related Immunotherapy (passive) None
CS6253 Cogpep™,
CS-6253
Alzheimer's Disease (Phase 1) Artery Therapeutics, Inc. Amyloid-Related, Cholesterol Small Molecule
CST-103 Clenbuterol Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 2) Other Neurotransmitters Small Molecule Asthma, in countries outside the U.S.
CST-2032 Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2) CuraSen Therapeutics, Inc. Other Neurotransmitters Small Molecule
CT1812 Elayta Alzheimer's Disease (Phase 2) Cognition Therapeutics Inc. Amyloid-Related Small Molecule
Curcumin diferuloylmethane,
Longvida™
Alzheimer's Disease (Phase 2) Verdure Sciences Other, Unknown Supplement, Dietary None
CVN424 Parkinson's Disease (Phase 2) Cerevance Other Neurotransmitters Small Molecule
CX516 Ampalex Alzheimer's Disease (Discontinued) Cortex Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule None
CY6463 IW-6463 Alzheimer's Disease (Phase 2) Cyclerion Inflammation Small Molecule
Dapagliflozin Farxiga,
Forxiga,
BMS 512148
Alzheimer's Disease (Phase 1/2) AstraZeneca, Bristol-Myers Squibb Other Small Molecule
Dapsone Avlosulfon,
Diaminodiphenylsulfone,
DDS
Alzheimer's Disease (Inactive) Immune Network Ltd. Other Small Molecule Leprosy, malaria, some bacterial skin infections
Dasatinib + Quercetin Alzheimer's Disease (Phase 1/2) Tau, Other Combination, Small Molecule, Supplement, Dietary
Davunetide NAP,
AL-108
Mild Cognitive Impairment (Discontinued), Progressive Supranuclear Palsy (Discontinued), Schizophrenia (Discontinued), Frontotemporal Dementia (Inactive) Allon Therapeutics Inc., Paladin Labs Inc. Tau Other
Dayvigo Lemborexant,
E2006
Alzheimer's Disease (Phase 2) Eisai Co., Ltd. Other Small Molecule Insomnia
Deep Brain Stimulation-fornix DBS-f Alzheimer's Disease (Phase 3) Functional Neuromodulation Ltd Unknown Procedural Intervention
Deep Brain Stimulation-nucleus basalis of Meynert DBS-nbM Alzheimer's Disease (Phase 2) Cholinergic System, Other Procedural Intervention
Deferiprone Ferriprox Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2/3), Amyotrophic Lateral Sclerosis (Phase 2/3) Apotex Inc., Chiesi Pharmaceuticals Inc. Metals Small Molecule Iron overload due to thalassemia syndromes
Dexpramipexole R-pramipexole,
RPPX,
KNS-760704 ,
BIIB 050
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) Biogen, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule
Dimebon Dimebolin,
Latrepirdine,
Pf-01913539
Alzheimer's Disease (Discontinued), Huntington's Disease (Discontinued) Medivation, Inc. Other Neurotransmitters, Unknown Small Molecule Anti-histamine use in Russia
Dipraglurant ADX48621 Parkinson's Disease (Discontinued) Addex Therapeutics Other Neurotransmitters Small Molecule
DNL151 BIIB122 Parkinson's Disease (Phase 2) Biogen, Denali Therapeutics Inc. Inflammation, Other Small Molecule
DNL201 Parkinson's Disease (Inactive) Biogen, Denali Therapeutics Inc. Inflammation, Other Small Molecule
DNL343 Amyotrophic Lateral Sclerosis (Phase 2/3) Denali Therapeutics Inc. Other Small Molecule
DNL593 PTV:PGRN,
TAK-594
Frontotemporal Dementia (Phase 1/2) Denali Therapeutics Inc., Takeda Pharmaceutical Company Other Other
DNL747 SAR443060 Alzheimer's Disease (Inactive), Amyotrophic Lateral Sclerosis (Inactive) Denali Therapeutics Inc., Sanofi Inflammation Small Molecule
DNL788 SAR443820 Amyotrophic Lateral Sclerosis (Phase 2) Denali Therapeutics Inc., Sanofi Inflammation Small Molecule
DNL919 TAK-920,
ATV:TREM2
Alzheimer's Disease (Discontinued) Denali Therapeutics Inc., Takeda Pharmaceutical Company Amyloid-Related, Inflammation Immunotherapy (passive)
Docosahexaenoic acid (DHA) Omega-3 fatty acid Alzheimer's Disease (Phase 4) Martek Biosciences Corporation, NeuroBioPharm, Inc. Other Supplement, Dietary
Donanemab N3pG-Aβ Monoclonal Antibody,
LY3002813
Alzheimer's Disease (Phase 3) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
Donepezil Aricept™,
Donepezil hydrochloride,
Eranz®,
E 2020
Alzheimer's Disease (Approved), Dementia with Lewy Bodies (Inactive), Down's Syndrome (Inactive), Parkinson's Disease Dementia (Inactive) Corium, Inc., Eisai Co., Ltd., Pfizer Cholinergic System Small Molecule Alzheimer's Disease, Dementia with Lewy Bodies (Japan)
Dronabinol THC ,
Marinol,
Syndros,
delta-9-tetrahydrocannabinol,
delta-9-THC
Alzheimer's Disease (Phase 2) AbbVie, Others Other Neurotransmitters Small Molecule Anorexia and weight loss in people with AIDS; Second-line treatment of nausea and vomiting due to chemotherapy
E2511 Alzheimer's Disease (Phase 1) Eisai Co., Ltd. Cholinergic System Small Molecule
E2814 Alzheimer's Disease (Phase 1/2) Eisai Co., Ltd. Tau Immunotherapy (passive)
Edaravone MCI-186,
Radicava®,
Radicut®,
MT-1186,
FAB122
Amyotrophic Lateral Sclerosis (Phase 4) Mitsubishi Tanabe Pharma Other Small Molecule Amyotrophic Lateral Sclerosis
Edicotinib JNJ-40346527,
JNJ-527,
PRV-6527
Alzheimer's Disease (Phase 1) Janssen Inflammation Small Molecule
Edonerpic T-817 MA, T 817 Alzheimer's Disease (Discontinued) Toyama Chemical Co., Ltd. Other, Unknown Small Molecule
Efavirenz Efavirenz Alzheimer's Disease (Phase 1) Amyloid-Related, Tau, Cholesterol Small Molecule HIV infection
EHT 0202 Etazolate Alzheimer's Disease (Phase 2) ExonHit Therapeutics Other Small Molecule None
Elenbecestat E2609,
BACE inhibitor
Alzheimer's Disease (Discontinued) Biogen, Eisai Co., Ltd. Amyloid-Related Small Molecule
ELND005 AZD-103,
Scyllo-inositol,
cyclohexane-1,2,3,4,5,6-hexol
Alzheimer's Disease (Inactive) Elan Corporation, Opko Health, Speranza Therapeutics, Transition Therapeutics, Inc. Amyloid-Related Small Molecule None
Empagliflozin Jardiance,
BI-10773
Alzheimer's Disease (Phase 1) Boehringer Ingelheim, Eli Lilly & Co. Other Small Molecule Type 2 Diabetes, Cardiovascular disease
Emrusolmin Anle138b,
TEV-56286
Parkinson's Disease (Phase 1/2) MODAG GmbH, Teva Tau, alpha-synuclein, Other Small Molecule
Emtricitabine Alzheimer's Disease (Phase 1) Gilead Sciences, Inc. Other Small Molecule
Encenicline EVP-6124 ,
MT-4666,
α7-nAChR agonist
Alzheimer's Disease (Discontinued), Schizophrenia (Discontinued) FORUM Pharmaceuticals Inc., Mitsubishi Tanabe Pharma Cholinergic System Small Molecule None
Engensis VM202, pCK-HGF-X7, NL003, hepatocyte growth factor Amyotrophic Lateral Sclerosis (Phase 2) Helixmith Other DNA/RNA-based
Epigallocatechin Gallate (EGCG) Sunphenon EGCg Alzheimer's Disease (Phase 2/3), Down's Syndrome (Phase 2), Multiple System Atrophy (Phase 3) Taiyo International Amyloid-Related, Inflammation, Other Supplement, Dietary
Epothilone D BMS-241027 Alzheimer's Disease (Discontinued) Bristol-Myers Squibb Tau Small Molecule
Eptastigmine MF 201 Alzheimer's Disease (Discontinued) Mediolanum Cholinergic System Small Molecule None
Estrogen Premarin™ Alzheimer's Disease (Discontinued) Other Other Hormone Replacement Therapy
Etanercept Enbrel™ Alzheimer's Disease (Phase 2) Amgen, Inc., Pfizer Inflammation Immunotherapy (passive) Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondilysis
EVP-0962 EVP 0015962 Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) FORUM Pharmaceuticals Inc. Amyloid-Related Small Molecule
Exenatide Exendin-4,
Byetta,
Bydureon
Alzheimer's Disease (Inactive), Parkinson's Disease (Phase 3) Other Small Molecule Diabetes mellitus in US
Ezeprogind AZP2006 ,
AZP-2006
Progressive Supranuclear Palsy (Phase 2) AlzProtect Tau, Inflammation, Other Small Molecule
Flurizan™ tarenflurbil ,
r-flurbiprofen,
MPC-7869
Alzheimer's Disease (Discontinued) Myriad Genetics & Laboratories Amyloid-Related Small Molecule None
Focused Ultrasound – Blood-Brain Barrier FUS-BBB,
MRgFUS,
MRI-Guided Focused Ultrasound,
FUS+MB
Alzheimer's Disease (Phase 1), Amyotrophic Lateral Sclerosis (Phase 1), Mild Cognitive Impairment (Phase 1), Parkinson's Disease (Phase 1) Amyloid-Related, Other Procedural Intervention
Fosgonimeton ATH-1017,
NDX-1017
Alzheimer's Disease (Phase 2/3), Dementia with Lewy Bodies (Phase 2), Parkinson's Disease Dementia (Phase 2) Athira Pharma Other Small Molecule
FRM-0334 EVP-0334 Frontotemporal Dementia (Discontinued) FORUM Pharmaceuticals Inc. Other Small Molecule
G-CSF Filgrastim Alzheimer's Disease (Phase 2) Other Small Molecule Neutropenia in US
Galantamine Razadyne™,
Reminyl™,
Nivalin®
Alzheimer's Disease (Approved) Janssen, Ortho-McNeil Pharmaceutical, Sanochemia Pharmazeutika, Shire, Takeda Pharmaceutical Company Cholinergic System Small Molecule Mild to Moderate Alzheimer's disease
Gammagard® Intravenous Immunoglobulin,
IVIg
Alzheimer's Disease (Discontinued) Baxter Healthcare Amyloid-Related, Inflammation Immunotherapy (passive) Immunodeficiency conditions
Gamunex Intravenous Immunoglobulin,
Human Albumin Combined With Flebogamma
Alzheimer's Disease (Phase 2/3) Grifols Biologicals Inc. Amyloid-Related, Inflammation Combination, Immunotherapy (passive) Immunodeficiency, chronic inflammatory demyelinating neuropathy
Gantenerumab RO4909832,
RG1450,
R1450
Alzheimer's Disease (Discontinued) Chugai Pharmaceutical Co., Ltd., Hoffmann-La Roche Amyloid-Related Immunotherapy (passive)
GC021109 Alzheimer's Disease (Phase 1) GliaCure Inflammation Small Molecule
Gemfibrozil Lopid,
Jezil,
Gen-Fibro
Alzheimer's Disease (Phase 1) Cholesterol Small Molecule Hyperlipidemia
Gosuranemab BIIB092,
BMS-986168, IPN007
Progressive Supranuclear Palsy (Discontinued), Alzheimer's Disease (Discontinued) Biogen, Bristol-Myers Squibb Tau Immunotherapy (passive)
GRF6019 Alzheimer's Disease (Phase 2) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other
GRF6021 AKST/GRF6021 Parkinson's Disease Dementia (Phase 2) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other
GSK239512 Alzheimer's Disease (Discontinued) GlaxoSmithKline (GSK) Cholinergic System, Other Neurotransmitters Small Molecule
GSK933776 Alzheimer's Disease (Inactive) GlaxoSmithKline (GSK) Amyloid-Related Immunotherapy (passive)
GSK2647544 GSK-2647544 Alzheimer's Disease (Phase 1) GlaxoSmithKline (GSK) Cholesterol Small Molecule
Guanfacine Intuniv,
SPD503,
Afken,
Estulic,
Tenex
Alzheimer's Disease (Phase 3) Other Neurotransmitters Small Molecule Attention-deficit hyperactivity disorder, hypertension
GV-971 sodium oligomannate,
sodium oligo-mannurarate
Alzheimer's Disease (Inactive) Shanghai Green Valley Pharmaceuticals Amyloid-Related, Inflammation Small Molecule
GV1001 RIAVAXTM, Tertomotide Alzheimer's Disease (Phase 3) GemVax & KAEL Bio Other Immunotherapy (active) Pancreatic cancer (Korea)
HF0220 Alzheimer's Disease (Discontinued) Newron Inflammation Small Molecule
HMTM LMTM,
LMTX, LMT-X,
TRx0237,
Tau aggregation inhibitor (TAI),
Methylene Blue
Alzheimer's Disease (Phase 3), Frontotemporal Dementia (Phase 3) TauRx Therapeutics Ltd Tau Small Molecule Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
HTL0018318 Alzheimer's Disease (Inactive), Dementia with Lewy Bodies (Inactive) Allergan plc, Sosei Heptares Cholinergic System Small Molecule
Huperzine A ZT-1,
DEBIO 9902 ,
Qian ceng ta,
Cerebra capsule,
Pharmassure Memorall capsule
Alzheimer's Disease (Inactive) Debiopharm Group™, Neuro-Hitech, Inc. Cholinergic System Small Molecule, Supplement, Dietary None
IBC-Ab002 Alzheimer's Disease (Phase 1) ImmunoBrain Checkpoint Amyloid-Related, Inflammation, Other Immunotherapy (passive)
Ibuprofen Advil™,
Nuprin™ ,
Motrin™
Alzheimer's Disease (Discontinued) Amyloid-Related, Inflammation Small Molecule Pain and Fever
Iclepertin BI 425809 Alzheimer's Disease (Discontinued), Schizophrenia (Phase 3) Boehringer Ingelheim Other Neurotransmitters Small Molecule
Idalopirdine Lu AE58054,
SGS 518
Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
Idebenone Catena,
Sovrima
Alzheimer's Disease (Discontinued) Takeda Pharmaceutical Company Other Small Molecule None
Intepirdine RVT-101,
SB 742457 ,
GSK 742457
Alzheimer's Disease (Discontinued), Dementia with Lewy Bodies (Discontinued) Axovant Sciences Ltd. Other Neurotransmitters Small Molecule
Intranasal oxytocin Syntocinon,
Pitocin
Frontotemporal Dementia (Phase 2) Other Other
Inzomelid Alzheimer's Disease (Phase 1), Parkinson's Disease (Phase 1) Inflazome Ltd. Inflammation Small Molecule
ION464 BIIB101,
IONIS-BIIB6Rx
Multiple System Atrophy (Phase 1) Biogen, IONIS Pharmaceuticals alpha-synuclein DNA/RNA-based
Irsenontrine E2027 Dementia with Lewy Bodies (Phase 2) Eisai Co., Ltd. Other Small Molecule
JNJ-63733657 Mild AD (Phase 2) Janssen Tau Immunotherapy (passive)
KarXT xanomeline-trospium Alzheimer's Disease (Phase 3) Karuna Therapeutics Cholinergic System Combination, Small Molecule
Ketasyn Axona,
Caprylic Acid,
AC-1202
Alzheimer's Disease (Phase 4) Cerecin Pte. Ltd. Other Supplement, Dietary
kMCT-ONS medium chain triglyceride-based ketogenic oral nutritional supplement, kMCT Alzheimer's Disease (Not Regulated) Nestlé Health Science Other Supplement, Dietary
Kynmobi APL-130277,
apomorphine hydrochloride sublingual thin film
Parkinson's Disease (Approved) Sunovion Pharmaceuticals Inc. Other Neurotransmitters Small Molecule
Ladostigil Ladostigil hemitartrate,
TV3326
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Discontinued) Avraham Pharmaceuticals Ltd Cholinergic System Small Molecule
Lanabecestat AZD3293 ,
LY3314814,
BACE inhibitor
Alzheimer's Disease (Discontinued) AstraZeneca, Eli Lilly & Co. Amyloid-Related Small Molecule
Latozinemab AL001,
GSK4527223
Frontotemporal Dementia (Phase 3), Amyotrophic Lateral Sclerosis (Phase 2) Alector, GlaxoSmithKline (GSK) Other Immunotherapy (passive)
Lenalidomide Revlimid Alzheimer's Disease (Phase 2) Celgene Corporation Amyloid-Related, Inflammation Small Molecule Multiple myeloma, lymphoma, myelodysplastic syndromes
Leqembi Lecanemab-irmb,
BAN2401,
mAb158
Alzheimer's Disease (Approved) BioArctic AB, Biogen, Eisai Co., Ltd. Amyloid-Related Immunotherapy (passive)
Leuprolide Leuprolide acetate ,
Lupron Depot,
Eligard
Alzheimer's Disease (Phase 2) Tolmar Pharmaceuticals, Inc. Other Other Advanced prostate cancer
Levetiracetam Keppra Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued) UCB S.A. Amyloid-Related, Other Small Molecule Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries
Levodopa L-Dopa, Sinemet,
Duodopa, Duopa,
Inbrija,
Parcopa,
Prolopa,
Rytary,
Stalevo,
Foslevodopa
Parkinson's Disease (Approved) AbbVie, Acorda Therapeutics, Inc., Amneal Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule
Linopirdine DuP996 Alzheimer's Disease (Discontinued) Other Small Molecule None
Liraglutide Victoza™,
Saxenda™
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2) Novo Nordisk A/S Other Other Diabetes, weight loss
LM11A-31-BHS LM11A-31 Alzheimer's Disease (Phase 2) PharmatrophiX Other Small Molecule
Lomecel-B mesenchymal stem cells Alzheimer's Disease (Phase 2) Longeveron Inflammation, Other Other
Lornoxicam Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) JSW Lifesciences Inflammation Small Molecule Pain in US
Losartan Cozaar®,
MK0954
Alzheimer's Disease (Phase 2) Merck Other Small Molecule Hypertension, diabetic neuropathy
LTI-291 Parkinson's Disease (Phase 2) Lysosomal Therapeutics Inc. Other Small Molecule
LU25-109 Alzheimer's Disease (Discontinued) Cholinergic System Small Molecule None
Lu AF20513 Alzheimer's Disease (Discontinued) Lundbeck, Otsuka Pharmaceutical Co., Ltd. Amyloid-Related Immunotherapy (active)
LU AF82422 Parkinson's Disease (Phase 1), Multiple System Atrophy (Phase 2) Genmab A/S, Lundbeck alpha-synuclein Immunotherapy (passive)
Lu AF87908 hC10.2 Alzheimer's Disease (Phase 1) Lundbeck Tau Immunotherapy (passive)
Lu AF88434 Mild Cognitive Impairment (Discontinued) Lundbeck Other Small Molecule
Lumateperone ITI-007 Alzheimer's Disease (Phase 3), Schizophrenia (Phase 3), Bipolar Disorder (Phase 3) Bristol-Myers Squibb, Intra-Cellular Therapies, Inc. Other Neurotransmitters Small Molecule
LX1001 AAVrh.10-APOE2,
AAVrh.10hAPOE2
Alzheimer's Disease (Phase 1) Lexeo Therapeutics Amyloid-Related DNA/RNA-based
LY2599666 Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
LY2886721 BACE inhibitor Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule
LY3202626 BACE Inhibitor Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule
LY3372689 Alzheimer's Disease (Phase 2) Eli Lilly & Co. Tau Small Molecule
LY3884961 PR001,
PR001A
Parkinson's Disease (Phase 1/2) Eli Lilly & Co., Prevail Therapeutics Other DNA/RNA-based
LY3884963 PR006 Frontotemporal Dementia (Phase 1/2) Eli Lilly & Co., Prevail Therapeutics Other DNA/RNA-based
Masitinib Masivet,
Kinavet,
AB1010,
Masitinib mesylate
Alzheimer's Disease (Phase 3), Amyotrophic Lateral Sclerosis (Phase 3) AB Science Other Small Molecule
Masupirdine SUVN-502 Alzheimer's Disease (Phase 3) Suven Life Sciences Ltd Other Neurotransmitters Small Molecule
MEDI1814 Alzheimer's Disease (Phase 1) AstraZeneca, Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
Melatonin Alzheimer's Disease (Phase 2) Other Supplement, Dietary None
MEM 1003 BAY Z 4406 Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued), Vascular Dementia (Discontinued), Bipolar Disorder (Discontinued) Memory Pharmaceuticals Corporation Other Small Molecule None
Memantine Ebixa™,
Namenda™ ,
Axura®,
Akatinol®,
Memary®
Alzheimer's Disease (Approved) Forest Laboratories, Inc., Lundbeck, Merz Pharma Other Neurotransmitters Small Molecule Alzheimer's Disease
MemorEM Transcranial Electromagnetic Treatment TEMT Alzheimer's Disease (Phase 1) NeuroEM Therapeutics, Inc. Amyloid-Related, Other Procedural Intervention
Metformin Glucophage,
Glucophage XR
Alzheimer's Disease (Phase 2/3) Other Small Molecule Type 2 Diabetes
Methylphenidate Ritalin, Concerta Alzheimer's Disease (Phase 4) Other Neurotransmitters Small Molecule Attention-deficit hyperactivity disorder (ADHD), narcolepsy
Metrifonate trichlorfon Alzheimer's Disease (Discontinued) Cholinergic System Small Molecule None
Mevidalen LY3154207,
Mevidalen hydroxybenzoate
Parkinson's Disease Dementia (Phase 2), Dementia with Lewy Bodies (Phase 2) Eli Lilly & Co. Other Neurotransmitters Small Molecule
Milameline CI 979 Alzheimer's Disease (Discontinued) Aventis Pharmaceuticals, Inc. (was Hoechst) Cholinergic System Small Molecule None
Minocycline Solodyn,
Arestin,
Minocin,
Dynacin
Alzheimer's Disease (Discontinued) Other Small Molecule
Minzasolmin UCB0599,
NPT200-11
Parkinson's Disease (Phase 2) Neuropore Therapies, Inc., Novartis Pharmaceuticals Corporation, UCB S.A. alpha-synuclein Small Molecule
Mirtazapine Remeron,
esmirtazapine,
Org 50081
Alzheimer's Disease (Phase 3) Other Neurotransmitters Small Molecule
MK-1942 Alzheimer's Disease (Discontinued) Merck Unknown Small Molecule
MK-2214 Alzheimer's Disease (Phase 1) Merck Tau Immunotherapy (passive)
MK-7622 Alzheimer's Disease (Discontinued) Merck Unknown Small Molecule
MK-8189 Alzheimer's Disease (Phase 1) Merck Other Neurotransmitters Small Molecule
MKC-231 Alzheimer's Disease (Inactive) Mitsubishi Tanabe Pharma Unknown Small Molecule None
Montelukast Singulair, MK0476 Alzheimer's Disease (Phase 2) Intelgenx Inflammation Small Molecule Asthma
MSDC-0160 Mitoglitazone Alzheimer's Disease (Phase 2) Metabolic Solutions Development Company Other Small Molecule
Multivitamin-mineral Supplement Centrum Silver Mild Cognitive Impairment (Not Regulated) Pfizer Other Supplement, Dietary
MW150 MW01-18-150SRM Alzheimer's Disease (Phase 2) Neurokine Therapeutics Inflammation, Other Small Molecule
MW151 MW01-2-151SRM,
Minozac,
MW01-2-151WH,
compound 17
Alzheimer's Disease (Phase 1) ImmunoChem Therapeutics, LLC Inflammation Small Molecule
NA-831 Traneurocin Alzheimer's Disease (Phase 2) Biomed Industries, NeuroActiva™ Inc. Cholinergic System Small Molecule
Nabilone Cesamet Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 2) Bausch Health Companies Inc. Other Neurotransmitters Small Molecule Nausea associated with cancer chemotherapy (US and other countries); pain spasticity in multiple sclerosis (Canada and other countries).
Naproxen Aleve™,
Anaprox™,
Naprosyn™
Alzheimer's Disease (Discontinued) Procter & Gamble Inflammation Small Molecule Over-the-counter drug for reduction of pain, fever, inflammation, and stiffness.
Nasal Insulin Detemir,
Levemir,
Humulin,
Novolin,
glulisine
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) Amyloid-Related, Other Small Molecule, Other Diabetes
NE3107 HE3286 Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 1/2) BioVie Pharma Inflammation, Other Small Molecule
Nefiracetam Alzheimer's Disease (Discontinued) Daiichi Sankyo Pharmaceuticals Cholinergic System Small Molecule None
Neflamapimod VX-745 Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Huntington's Disease (Discontinued) CervoMed, Inc. Inflammation Small Molecule
Nelonicline ABT-126 Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) AbbVie Cholinergic System Small Molecule
Nelotanserin APD-125 Dementia with Lewy Bodies (Discontinued) Axovant Sciences Ltd. Other Neurotransmitters Small Molecule
NeoTrofin AIT-082,
leteprinim
Alzheimer's Disease (Discontinued) NeoTherapeutics, Inc. Unknown Small Molecule None
Neramexane MRZ 2/579 Alzheimer's Disease (Discontinued) Forest Laboratories, Inc., Merck Other Neurotransmitters Small Molecule None
NeuroAD Repetitive Transcranial Magnetic Stimulation ,
rTMS-Cog
Alzheimer's Disease (Rejected) Neuronix Ltd Other Procedural Intervention
NGX267 AF267B Alzheimer's Disease (Inactive) TorreyPines Therapeutics, Inc. Cholinergic System Small Molecule None
NIC5-15 Pinitol,
D-Pinitol
Alzheimer's Disease (Phase 2) Humanetics Pharmaceuticals Corporation Amyloid-Related, Other Small Molecule, Supplement, Dietary
Nicotinamide Riboside Niagen,
NR,
Nicotinamide,
Vitamin B3
Alzheimer's Disease (Phase 1), Parkinson's Disease (Phase 2), Mild Cognitive Impairment (Phase 1/2) ChromaDex, Others Other Supplement, Dietary
Nilotinib Tasigna,
AMN107
Parkinson's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Alzheimer's Disease (Phase 3) KeifeRx Other Small Molecule Chronic myeloid leukemia
Nilvadipine Nilvad,
Nivadil,
ARC029
Alzheimer's Disease (Inactive) Archer Pharmaceuticals, Inc. Other Small Molecule
Nimodipine Nimotop Frontotemporal Dementia (Discontinued) Bayer Metals Small Molecule Subarachnoid hemorrhage
NIO752 Progressive Supranuclear Palsy (Phase 1), Alzheimer's Disease (Phase 1) Novartis Pharmaceuticals Corporation Tau DNA/RNA-based
NPT520-34 Amyotrophic Lateral Sclerosis (Phase 1), Parkinson's Disease (Phase 1) Neuropore Therapies, Inc. alpha-synuclein, Inflammation, Other Small Molecule
NS2330 Tesofensine Alzheimer's Disease (Discontinued) NeuroSearch A/S Other Neurotransmitters Small Molecule
NTRX-07 MDA7 Alzheimer's Disease (Phase 1) NeuroTherapia, Inc. Inflammation, Other Small Molecule
Nuplazid Pimavanserin,
ACP-103,
Pimavanserin tartrate
Alzheimer's Disease (Rejected), Schizophrenia (Phase 3), Dementia (Rejected), Depression (Discontinued) Acadia Pharmaceuticals Other Neurotransmitters Small Molecule Parkinson's psychosis
NurOwn™ MSC-NTF Cells,
debamestrocel ,
Neurotrophic factors-secreting Mesenchymal Stromal Cells
Amyotrophic Lateral Sclerosis (Phase 3) BrainStorm Cell Therapeutics, Inc. Other Other
NYX-458 PD-MCI (Discontinued) Aptinyx Inc. Other Neurotransmitters Small Molecule
Obicetrapib TA-8995 Alzheimer's Disease (Phase 2) NewAmsterdam Pharma Cholesterol Small Molecule
Octagam®10% Intravenous Immunoglobulin,
NewGam
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Inactive) Octapharma Amyloid-Related, Inflammation Immunotherapy (passive) Immunodeficiency disorders
OLX-07010 Alzheimer's Disease (Phase 1) Oligomerix, Inc. Tau Small Molecule
ORM-12741 Alzheimer's Disease (Phase 2) Orion Pharma Other Neurotransmitters Small Molecule
PBFT02 Frontotemporal Dementia (Phase 1/2) Passage Bio Other DNA/RNA-based
PBT2 PBT-2 Alzheimer's Disease (Inactive), Huntington's Disease (Inactive) Alterity Therapeutics Amyloid-Related, Metals Small Molecule
Pepinemab VX15,
VX15/2503
Alzheimer's Disease (Phase 1/2), Huntington's Disease (Phase 2) Vaccinex, Inc. Inflammation Immunotherapy (passive)
PF-05212377 PF-5212377,
WYE-103760,
SAM-760
Alzheimer's Disease (Discontinued) Pfizer Other Neurotransmitters Small Molecule
PF-06648671 Alzheimer's Disease (Discontinued) Pfizer Amyloid-Related Small Molecule
PF-06751979 BACE inhibitor Alzheimer's Disease (Discontinued) Pfizer Amyloid-Related Small Molecule
PF-06852231 Alzheimer's Disease (Discontinued) Pfizer Cholinergic System Small Molecule
Phenserine Alzheimer's Disease (Inactive) Annovis Bio, TorreyPines Therapeutics, Inc. Cholinergic System Small Molecule
Physostigmine Salicylate Synapton Alzheimer's Disease (Discontinued) Forest Laboratories, Inc. Cholinergic System Small Molecule
Pioglitazone AD4833,
Actos®,
Glustin™,
Piozone®
Mild Cognitive Impairment (Phase 3) Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. Inflammation, Other Small Molecule Type 2 diabetes mellitus
Piromelatine Neu-P11 Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Neurotransmitters, Other Small Molecule
PNT001 Alzheimer's Disease (Phase 1), Traumatic Brain Injury (Phase 1) Pinteon Therapeutics Tau Immunotherapy (passive)
Ponezumab PF-04360365 Alzheimer's Disease (Discontinued), Cerebral Amyloid Angiopathy (Discontinued) Pfizer Amyloid-Related Immunotherapy (passive) None
Prasinezumab PRX002, RO7046015, RG7935, NEOD002 Parkinson's Disease (Phase 2) Hoffmann-La Roche, Prothena alpha-synuclein Immunotherapy (passive)
Prazosin Prazosin hydrochloride,
Minipress,
Hypovase,
Vasoflex
Alzheimer's Disease (Phase 4) Other Neurotransmitters Small Molecule Hypertension
Prednisone Alzheimer's Disease (Discontinued) Inflammation Small Molecule
PRI-002 Contraloid,
contraloid acetate,
RD2
Alzheimer's Disease (Phase 1) Priavoid GmbH Amyloid-Related Small Molecule
Pridopidine ACR16,
TV-7820,
Huntexil,
ASP2314
Amyotrophic Lateral Sclerosis (Phase 2/3), Huntington's Disease (Phase 3), Parkinson's Disease (Inactive) Prilenia Therapeutics Other Small Molecule
Propentofylline HWA 285,
PPF
Alzheimer's Disease (Discontinued) Unknown Small Molecule
Protollin Alzheimer's Disease (Phase 1) I-MAB Biopharma Co., Ltd., Jiangsu Nhwa Pharmaceutical Co., Ltd Inflammation Immunotherapy (active)
PRX-03140 Potassium salt Alzheimer's Disease (Inactive) Epix Pharmaceuticals Other Small Molecule
PRX012 Alzheimer's Disease (Phase 1) Prothena Amyloid-Related Immunotherapy (passive)
PU-AD PU-HZ151,
icapamespib
Alzheimer's Disease (Phase 2) Samus Therapeutics Other Small Molecule
PXT864 PXT00864 Alzheimer's Disease (Discontinued) Pharnext Other Neurotransmitters Combination, Small Molecule
QALSODY™ Tofersen,
BIIB067 ,
Ionis-SOD1Rx ,
ASO1
Amyotrophic Lateral Sclerosis (Approved) Biogen, IONIS Pharmaceuticals Other DNA/RNA-based ALS
QRL-101 QRA-244 Amyotrophic Lateral Sclerosis (Phase 1) QurAlis Corporation Other Small Molecule
QRL-201 Amyotrophic Lateral Sclerosis (Phase 1) QurAlis Corporation Other DNA/RNA-based
Rasagiline Rasagiline mesylate,
Azilect,
TVP-1012
Alzheimer's Disease (Phase 2), Parkinson's Disease (Approved), Amyotrophic Lateral Sclerosis (Inactive) Teva Other Neurotransmitters Small Molecule
Relyvrio Albrioza,
AMX0035
Amyotrophic Lateral Sclerosis (Approved), Alzheimer's Disease (Phase 2) Amylyx Pharmaceuticals Inc Other Combination, Small Molecule ALS
Rember TM Methylene Blue ,
methylthioninium (MT),
TRx-0014,
Tau aggregation inhibitor (TAI)
Alzheimer's Disease (Discontinued) TauRx Therapeutics Ltd Tau Small Molecule Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
Remternetug LY3372993,
N3pG-Abeta mAb
Alzheimer's Disease (Phase 3) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
Resveratrol trans-3,4',5-trihydroxystilbene Alzheimer's Disease (Phase 3), Mild Cognitive Impairment (Phase 4) Other Small Molecule, Supplement, Dietary
RG3487 RO5313534,
MEM 3454
Alzheimer's Disease (Inactive) Cholinergic System Small Molecule
RG6289 Alzheimer's Disease (Phase 1) Hoffmann-La Roche Amyloid-Related Small Molecule
RG7129 RO5508887,
BACE Inhibitor
Alzheimer's Disease (Discontinued) Roche Amyloid-Related Small Molecule
RG7345 RO6926496 Alzheimer's Disease (Discontinued) Tau Immunotherapy (passive)
Rilapladib SB-659032 Alzheimer's Disease (Discontinued) GlaxoSmithKline (GSK) Other Small Molecule
Riluzole Rilutek®,
RP 54274
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule Amyotrophic Lateral Sclerosis in many countries
Rivastigmine Exelon™,
Rivastigmine tartrate ,
Rivastach® Patch,
Prometax®,
SDZ ENA 713
Alzheimer's Disease (Approved), Parkinson's Disease Dementia (Approved) Novartis Pharmaceuticals Corporation Cholinergic System Small Molecule Mild to moderate Alzheimer’s disease and mild to moderate dementia related to Parkinson's disease
Rofecoxib Vioxx™ Alzheimer's Disease (Discontinued) Merck Inflammation Small Molecule Withdrawn from market
Rosiglitazone Rosiglitazone maleate,
Avandia
Alzheimer's Disease (Discontinued) GlaxoSmithKline (GSK) Other Small Molecule
Rotigotine Neupro Alzheimer's Disease (Phase 2), Frontotemporal Dementia (Phase 2) UCB S.A. Other Neurotransmitters Small Molecule Parkinson's disease, Restless Leg Syndrome
S-Equol Aus-131 Alzheimer's Disease (Phase 1) Ausio Pharmaceuticals, LLC Other Small Molecule
S 38093 Alzheimer's Disease (Discontinued) Servier Cholinergic System, Other Neurotransmitters Small Molecule
S47445 CX1632 Alzheimer's Disease (Discontinued) Cortex Pharmaceuticals, Inc., Servier Other Neurotransmitters Small Molecule
Sabeluzole R58735 Alzheimer's Disease (Inactive) Unknown Small Molecule
Safinamide Xadago,
Onstryv
Multiple System Atrophy (Phase 2), Parkinson's Disease (Approved) Newron, Zambon Company S.p.A. Other Neurotransmitters Small Molecule
SAGE-718 Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2), Huntington's Disease (Phase 2) Sage Therapeutics, Inc. Other Neurotransmitters Small Molecule
SAR110894D Alzheimer's Disease (Phase 2) Sanofi Other Small Molecule
SAR228810 Alzheimer's Disease (Discontinued) Sanofi Amyloid-Related Immunotherapy (passive)
Saracatinib AZD0530 Alzheimer's Disease (Discontinued), Parkinson's Disease (Phase 1) AstraZeneca Other Small Molecule
Sargramostim GM-CSF Leukine ,
Leukine®
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1) Genzyme, Partner Therapeutics, Inc., Sanofi Inflammation, Other, Unknown Other Bone Marrow Stimulation
SB 202026 Memric Alzheimer's Disease (Discontinued) Other Neurotransmitters Small Molecule
Seltorexant JNJ-42847922,
MIN-202
Alzheimer's Disease (Phase 2) Janssen Other Small Molecule
Semagacestat LY450139 Dihydrate ,
hydroxylvaleryl monobenzocaprolactam
Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule None
Semaglutide Ozempic,
Rybelsus
Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 2) Novo Nordisk A/S Other Other Type 2 Diabetes
Sembragiline RO4602522,
RG1577
Alzheimer's Disease (Discontinued) Evotech AG Other Neurotransmitters, Other Small Molecule
Semorinemab RO7105705 ,
MTAU9937A,
RG6100
Alzheimer's Disease (Phase 2) AC Immune SA, Genentech, Hoffmann-La Roche Tau Immunotherapy (passive)
Sensory Stimulation Systems GENUS,
Gamma entrainment using sensory stimuli,
GammaSense Stimulation
Alzheimer's Disease (Phase 3) Cognito Therapeutics, Inc. Amyloid-Related, Inflammation, Other Combination, Procedural Intervention
SGS-742 CGP-36742,
DVD-742
Alzheimer's Disease (Discontinued) Novartis Pharmaceuticals Corporation, Saegis Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule
Simufilam PTI-125,
sumifilam
Alzheimer's Disease (Phase 3) Cassava Sciences Amyloid-Related Small Molecule
Simvastatin Zocor®,
Lipex®,
Lipovas®,
Denan®
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Phase 4) Merck Cholesterol Small Molecule Hypercholesterolemia and diabetic cardiomyopathy.
SNP318 Alzheimer's Disease (Phase 1) SciNeuro Pharmaceuticals Inflammation Small Molecule
Solanezumab LY2062430 Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive) None
Souvenaid Fortasyn Connect Alzheimer's Disease (Not Regulated) Nutricia Other Supplement, Dietary
ST101 ZSET1446 Alzheimer's Disease (Inactive) Sonexa Therapeutics, Inc. Unknown Small Molecule
Suritozole MD 26479 Alzheimer's Disease (Discontinued) Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule
SUVN-G3031 Samelisant,
17v
Alzheimer's Disease (Phase 1) Suven Life Sciences Ltd Cholinergic System, Other Neurotransmitters Small Molecule
Suvorexant Belsomra,
MK-4305
Alzheimer's Disease (Approved) Merck Other Small Molecule Insomnia, Insomnia in mild to moderate Alzheimer's disease
T3D-959 DB959 Alzheimer's Disease (Phase 2) T3D Therapeutics, Inc. Other Small Molecule
Tacrine Cognex™ Alzheimer's Disease (Approved) Pfizer, Shionogi Pharma Cholinergic System Small Molecule
TAK-341 MEDI1341 Parkinson's Disease (Phase 1), Multiple System Atrophy (Phase 2) AstraZeneca, Takeda Pharmaceutical Company alpha-synuclein Immunotherapy (passive)
TB006 Alzheimer's Disease (Phase 1) TrueBinding, Inc. Inflammation Immunotherapy (passive)
Telmisartan Micardis Alzheimer's Disease (Phase 2) Boehringer Ingelheim Other Small Molecule Hypertension
Thalidomide Thalomid® Alzheimer's Disease (Discontinued) Celgene Corporation Amyloid-Related, Inflammation Small Molecule
Tideglusib NP031112,
Nypta® ,
Zentylor™ ,
Glycogen synthase kinase 3 inhibitor,
NP12
Alzheimer's Disease (Discontinued), Progressive Supranuclear Palsy (Discontinued) Zeltia Group Tau Small Molecule
Tilavonemab ABBV-8E12,
C2N 8E12,
HJ8.5
Progressive Supranuclear Palsy (Discontinued), Alzheimer's Disease (Discontinued) AbbVie, C2N Diagnostics, LLC Tau Immunotherapy (passive)
TPI 287 Alzheimer's Disease (Inactive), Corticobasal Degeneration (Inactive), Progressive Supranuclear Palsy (Phase 1) Cortice Biosciences Tau Small Molecule
TPN-101 OBP-601,
BMS-986001,
censavudine,
festinavir,
4'-ethynyl stavudine,
4'-ethynyl-d4T
ALS-FTD (Phase 2), Progressive Supranuclear Palsy (Phase 2) Transposon Therapeutics Inflammation Small Molecule, DNA/RNA-based
Trappsol® Cyclo™ HP-beta-CD,
HPbetaCD
Alzheimer's Disease (Phase 2) Cyclo Therapeutics, Inc. Cholesterol Other
Trazodone Trazodone hydrochloride,
Oleptro,
Desyrel
Alzheimer's Disease (Phase 3), Mild Cognitive Impairment (Phase 3), Amyotrophic Lateral Sclerosis (Phase 2/3) Other Neurotransmitters Small Molecule Depression
Tricaprilin AC-1204 ,
Caprylic triglyceride,
AC-SD-03,
CER-000,
AC-OLE-O1-VA
Alzheimer's Disease (Phase 3) Cerecin Pte. Ltd. Other Supplement, Dietary, Other None
Trontinemab RO7126209,
RG6102 ,
Brain shuttle gantenerumab
Alzheimer's Disease (Phase 1) Hoffmann-La Roche Amyloid-Related Immunotherapy (passive)
Troriluzole BHV-4157, trigriluzole, FC-4157 Alzheimer's Disease (Discontinued) Biohaven Pharmaceuticals Other Neurotransmitters Other
TW001 FNP122,
FAB122,
oral edaravone
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 3) Treeway B.V. Other Small Molecule
UB-311 Alzheimer's Disease (Phase 2) United Neuroscience, Vaxxinity Amyloid-Related Immunotherapy (active)
UB-312 Parkinson's Disease (Phase 2) United Neuroscience, Vaxxinity alpha-synuclein Immunotherapy (active)
UCB7853 Parkinson's Disease (Phase 1) UCB S.A. alpha-synuclein Immunotherapy (passive)
Ulefnersen ION363,
Jacifusen
Amyotrophic Lateral Sclerosis (Phase 3) IONIS Pharmaceuticals Other DNA/RNA-based
Umibecestat CNP520,
BACE Inhibitor
Alzheimer's Disease (Discontinued) Amgen, Inc., Novartis Pharmaceuticals Corporation Amyloid-Related Small Molecule
Vafidemstat ORY-2001 Alzheimer's Disease (Phase 2) Oryzon Corporate Other Neurotransmitters Small Molecule
Valacyclovir Valtrex,
Valaciclovir,
256U87
Alzheimer's Disease (Phase 2) GlaxoSmithKline (GSK) Other Small Molecule Herpes virus outbreaks
Valproate Depakote,
Depakene,
Valproic acid ,
Divalproex sodium
Alzheimer's Disease (Inactive) Abbott Laboratories Other Neurotransmitters Small Molecule Epilepsy, Bipolar disorder, Migraine
Vanutide cridificar ACC-001,
PF-05236806
Alzheimer's Disease (Discontinued) Janssen Amyloid-Related Immunotherapy (active) None
Varenicline Champix™,
Chantix™,
Varenicline tartrate,
CP-526,555,
Alpha4 beta2 nicotinic receptor agonist
Alzheimer's Disease (Discontinued) Pfizer Cholinergic System Small Molecule Smoking cessation
Varoglutamstat PQ912 Alzheimer's Disease (Phase 2) Probiodrug AG, Vivoryon Therapeutics N.V. Amyloid-Related, Inflammation Small Molecule
Vascepa Icosapent ethyl (IPE),
Ethyl eicosapentaenoic acid (E-EPA),
AMR101,
Miraxion
Alzheimer's Disease (Phase 2/3) Other Small Molecule Severe hypertriglyceridemia, and to lower risk of cardiovascular events in people with elevated triglycerides
Venglustat Ibiglustat,
GZ/SAR402671,
Genz-682452
Parkinson's Disease (Inactive) Genzyme, Sanofi alpha-synuclein, Other Small Molecule
Verdiperstat AZD3241,
BHV-3241
Motor Neuron Disease (Discontinued), Multiple System Atrophy (Discontinued), Primary Progressive Aphasia (Phase 1) AstraZeneca, Biohaven Pharmaceuticals Inflammation, Other Small Molecule
Verubecestat MK-8931, MK-8931-009 ,
BACE inhibitor
Alzheimer's Disease (Discontinued) Merck Amyloid-Related Small Molecule
VGL101 Adult-onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (Phase 1) Vigil Neuroscience, Inc. Inflammation, Other Immunotherapy (passive)
Vodobatinib K0706,
SCC-138,
SCO-088
Parkinson's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) Sun Pharma Advanced Research Company Ltd. Other Small Molecule
VY-AADC VY-AADC01,
VY-AADC02
Parkinson's Disease (Discontinued) Neurocrine Biosciences, Voyager Therapeutics Other Neurotransmitters DNA/RNA-based
WVE-004 Frontotemporal Dementia (Discontinued), Amyotrophic Lateral Sclerosis (Discontinued) Wave Life Sciences USA, Inc. Other DNA/RNA-based
Xaliproden SR 57746A Alzheimer's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule
Xanamem UE 2343 Alzheimer's Disease (Phase 2) Actinogen Medical Other Small Molecule
XPro1595 Pegipanermin, INB03, NeuLiv, XENP1595, DN-TNF, XENP345,
XPro™ ,
LIVNate
Alzheimer's Disease (Phase 2), Mild Cognitive Impairment (Phase 2) INmune Bio Inc. Inflammation Other
Young Plasma Progressive Supranuclear Palsy (Inactive), Alzheimer's Disease (Inactive) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other
YTX-7739 Parkinson's Disease (Phase 1) Yumanity Therapeutics Other Small Molecule
Zagotenemab LY3303560 Alzheimer's Disease (Discontinued) Eli Lilly & Co. Tau, Unknown Immunotherapy (passive)