Name: LY3372993
Therapy Type: Immunotherapy (passive) (timeline)
Target Type: Amyloid-Related (timeline)
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Phase 1)
Company: Eli Lilly & Co.


LY3372993 is an investigational anti-Aβ monoclonal antibody. The company disclosed no information about LY3372993, or how it may differ from donanemab, Lilly’s Phase 2 Aβ antibody.


In November 2018, Lilly started a Phase 1 trial with the intention to compare LY3372993 to placebo in 100 healthy adults and people with MCI due to Alzheimer's disease or mild to moderate AD. The study delivered intravenous infusions of single or multiple escalating doses of LY3372993, and assessed adverse events, LY3372993 exposure in blood, and its ability to affect brain amyloid as measured by florbetapir PET. This study was set to run at eight U.S. centers until October 2020, but in April 2019, Lilly decided to terminate the trial after testing 36 healthy adults, and never enrolled any participants with AD. Study results were not made public.

In July 2020, Lilly began a separate Phase 1 study in people with AD. Thirty participants with clinically diagnosed mild cognitive impairment due to AD, or AD dementia, will receive multiple escalating doses of antibody, or placebo, over nine months. The primary outcome is the number of serious adverse events; secondary outcomes include pharmacokinetics, and change in brain amyloid from baseline to week 25. Conducted at seven U.S. sites, the trial will run through March 2022.

For all trials of LY3372993, see

Last Updated: 08 Oct 2020


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Therapeutics Citations

  1. Donanemab

External Citations


Further Reading

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