PAPER Alexandre-Silva V, Cominetti MR

Unraveling the dual role of ADAM10: Bridging the gap between cancer and Alzheimer's disease.

Mech Ageing Dev. 2024 Mar 19;219:111928. PubMed: 38513842

PAPER Shinzato GT, Assone T, Sandler PC, Pacheco-Barrios K, Fregni F, Radanovic M, Forlenza OV, Battistella LR

Non-invasive sound wave brain stimulation with Transcranial Pulse Stimulation (TPS) improves neuropsychiatric symptoms in Alzheimer's disease.

Brain Stimul. 2024 Mar 20;17(2):413-415. PubMed: 38513821

PAPER Wang Y, Sarnowski C, Lin H, Pitsillides AN, Heard-Costa NL, Choi SH, Wang D, Bis JC, Blue EE, Alzheimer's Disease Neuroimaging Initiative (ADNI), Boerwinkle E, De Jager PL, Fornage M, Wijsman EM, Seshadri S, Dupuis J, Peloso GM, DeStefano AL, Alzheimer's Disease Sequencing Project (ADSP)

Key variants via the Alzheimer's Disease Sequencing Project whole genome sequence data.

Alzheimers Dement. 2024 Mar 21; PubMed: 38511601

PAPER Kulkarni PG, Mohire VM, Waghmare PP, Banerjee T

Interplay of mitochondria-associated membrane proteins and autophagy: Implications in neurodegeneration.

Mitochondrion. 2024 Mar 20;76:101874. PubMed: 38514017

PAPER Moorthi P, Premkumar P, Priyanka R, Jayachandran KS, Anusuyadevi M

Corrigendum to "Pathological changes in hippocampal neuronal circuits underlie age-associated neurodegeneration and memory loss: Positive clue toward SAD" [Neuroscience 301 (2015) 90-105].

Neuroscience. 2024 Apr 19;544:140-141. Epub 2024 Mar 19 PubMed: 38513718

PAPER Craig RA 2nd, De Vicente J, Estrada AA, Feng JA, Lexa KW, Canet MJ, Dowdle WE, Erickson RI, Flores BN, Haddick PC, Kane LA, Lewcock JW, Moerke NJ, Poda SB, Sweeney Z, Takahashi RH, Tong V, Wang J, Yulyaningsih E, Solanoy H, Scearce-Levie K, Sanchez PE, Tang L, Xu M, Zhang R, Osipov M

Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases.

J Med Chem. 2024 Apr 11;67(7):5758-5782. Epub 2024 Mar 21 PubMed: 38511649

PAPER Perales-Puchalt J, Peltzer J, Fracachan-Cabrera M, Perez GA, Ramírez M, Greiner KA, Burns JM

Authors' Response to Peer Reviews of "Impact of the COVID-19 Pandemic on Latino Families With Alzheimer Disease and Related Dementias: Qualitative Interviews With Family Caregivers and Primary Care Providers".

JMIRx Med. 2024 Mar 8;5:e56439. PubMed: 38509604

PAPER Sokol DK, Lahiri DK

Alzheimer's drugs, APPlication for Down syndrome?

Ageing Res Rev. 2024 Apr;96:102281. Epub 2024 Mar 19 PubMed: 38513771

PAPER Luo T, Sang N, Liu Y, Zhou Y, Wu R, Bagdasarian FA, Wey HY, Lang J, Wang C, Bai P

Synthesis and preclinical evaluation of 11C-labeled 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine radioligands for RIPK1 positron emission tomography imaging.

Bioorg Chem. 2024 May;146:107279. Epub 2024 Mar 9 PubMed: 38513325

PAPER Shir D, Corriveau-Lecavalier N, Bermudez Noguera C, Barnard L, Pham NT, Botha H, Duffy JR, Clark HM, Utianski RL, Knopman DS, Petersen RC, Boeve BF, Murray ME, Nguyen AT, Reichard RR, Dickson DW, Day GS, Kremers WK, Graff-Radford NR, Jones DT, Machulda MM, Fields JA, Whitwell JL, Josephs KA, Graff-Radford J

Clinicoradiological and neuropathological evaluation of primary progressive aphasia.

J Neurol Neurosurg Psychiatry. 2024 Mar 21; PubMed: 38514176

Leonardo Tejo Gunawan

Hanyang University
Seoul, Korea, Republic of

Phillip Janowicz on Fast Plaque Clearance with Little ARIA? So Teases Trontinemab at AD/PD 2024

COMMENT Firstly, I think these results are fantastic and show the possibilities of BBB-crossing immunotherapy. The big question I would have thought is, have the patients been cured? Moreover, or alternatively, if the patients had been treated in their 20s, 30s,

TREM1 Muddles Myeloid Cell Metabolism and Memory in Old Mice

RESEARCH NEWS 2024-03-21 Research News The macrophage and microglial receptor TREM1 whips up inflammation. In its tizzy, the receptor also perturbs myeloid cell metabolism and hastens cognitive decline in older wild-type mice and in two models of amyloidosis, according to scienti

Michal Schwartz on TREM1 Muddles Myeloid Cell Metabolism and Memory in Old Mice

COMMENT The paper by Wilson et al. is extremely timely and important. It attributes a key role to myeloid cells in coping with aging in general, and age-related neurodegenerative diseases in particular, with an emphasis on Alzheimer’s disease, focusing on trigger

Elizabeth Bradshaw, Kirstin Tamucci on TREM1 Muddles Myeloid Cell Metabolism and Memory in Old Mice

COMMENT This paper highlights, and raises questions about, potential crosstalk between the peripheral immune system and central nervous system microglia and how this communication could be a powerful modulator of neurodegeneration. While the authors found very sm