PAPER Campese N, Palermo G, Del Gamba C, Beatino MF, Galgani A, Belli E, Del Prete E, Della Vecchia A, Vergallo A, Siciliano G, Ceravolo R, Hampel H, Baldacci F

Progress regarding the context-of-use of tau as biomarker of Alzheimer's disease and other neurodegenerative diseases.

Expert Rev Proteomics. 2021 Jan;18(1):27-48. Epub 2021 Mar 7 PubMed: 33545008

PAPER Ruksenaite J, Volkmer A, Jiang J, Johnson JC, Marshall CR, Warren JD, Hardy CJ

Primary Progressive Aphasia: Toward a Pathophysiological Synthesis.

Curr Neurol Neurosci Rep. 2021 Feb 4;21(3):7. PubMed: 33543347

PAPER Chrobak W, Pacut DW, Blomgren F, Rodin A, Swenson J, Ermilova I

Component of Cannabis, Cannabidiol, as a Possible Drug against the Cytotoxicity of Aβ(31-35) and Aβ(25-35) Peptides: An Investigation by Molecular Dynamics and Well-Tempered Metadynamics Simulations.

ACS Chem Neurosci. 2021 Feb 17;12(4):660-674. Epub 2021 Feb 5 PubMed: 33544587

PAPER Vasta R, D'Ovidio F, Logroscino G, Chiò A

The links between diabetes mellitus and amyotrophic lateral sclerosis.

Neurol Sci. 2021 Apr;42(4):1377-1387. Epub 2021 Feb 5 PubMed: 33544228

Christian Haass on Striking Microgliosis in New APP Knock-in Mice

COMMENT This is a mouse model for amyloidosis, which, finally, is freely available for the entire research community. This is a big issue, considering that many experiments were blocked or slowed due to legal issues with mouse models. I think this is a great sign ...

Striking Microgliosis in New APP Knock-in Mice

RESEARCH NEWS 2021-02-06 Research News A new APP knock-in mouse has hit the scene. Researchers led by Pascal Sanchez, Denali Therapeutics, San Francisco, California, described the details in a paper posted to bioRxiv on January 20. They humanized the Aβ sequence in the mouse APP ...

PAPER Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK, Lin CC, Davis S, Ha C, Nguyen H, Chau R, Yulyaningsih E, Solanoy H, Masoud ST, Liang R, Lin K, Thorne RG, Garceau D, Whitesell JD, Sasner M, Harris JA, Scearce-Levie K, Lewcock JW, Di Paolo G, Sanchez PE

Fibrillar Aβ causes profound microglial metabolic perturbations in a novel APP knock-in mouse model

bioRxiv. January 20, 2021.

Elyse Goodman

HCWW & MGHIHP
Boston, United States

Bernardino Ghetti

Indiana University
Indianapolis, United States

PAPER Milanowski ŁM, Ross OA, Friedman A, Hoffman-Zacharska D, Gorka-Skoczylas P, Jurek M, Koziorowski D, Wszolek ZK

Genetics of Parkinson's disease in the Polish population.

Neurol Neurochir Pol. 2021 Feb 4; PubMed: 33539026

PAPER Lee H, Lee MJ, Kim EJ, Huh GY, Lee JH, Cho H

Iron accumulation in the oculomotor nerve of the progressive supranuclear palsy brain.

Sci Rep. 2021 Feb 3;11(1):2950. PubMed: 33536537

PAPER Correction Lead O

Corrigendum to: Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy.

J Neuropathol Exp Neurol. 2021 Feb 4; PubMed: 33537733

PAPER Powers R, Etezadi-Amoli M, Arnold EM, Kianian S, Mance I, Gibiansky M, Trietsch D, Alvarado AS, Kretlow JD, Herrington TM, Brillman S, Huang N, Lin PT, Pham HA, Ullal AV

Smartwatch inertial sensors continuously monitor real-world motor fluctuations in Parkinson's disease.

Sci Transl Med. 2021 Feb 3;13(579) PubMed: 33536284

PAPER Minikel EV, Karczewski KJ, Martin HC, Cummings BB, Whiffin N, Rhodes D, Alföldi J, Trembath RC, van Heel DA, Daly MJ, Genome Aggregation Database Production Team, Genome Aggregation Database Consortium, Schreiber SL, MacArthur DG

Author Correction: Evaluating drug targets through human loss-of-function genetic variation.

Nature. 2021 Feb;590(7846):E56. PubMed: 33536628

PAPER Pes GM, Park YM, Sechi GP

Cholesterol Trafficking in the Brain: Are We Overlooking an Important Risk Factor for Parkinson Disease?

Neurology. 2021 Mar 9;96(10):465-466. Epub 2021 Feb 3 PubMed: 33536270