KU LeuvenLeuven, Belgium
COMMENT Alzheimer’s disease mouse modelling needs tricks, including overexpression of human genes such as APP, PSEN, or tau, and combinations of mutations in these genes, to induce relevant neuropathology. However, a complete model for AD, i.e., linking amyloid ...
COMMENT The article by Vogel and colleagues indicates the existence of four spatiotemporal patterns in Alzheimer’s disease (AD), with a prevalence ranging between 18-33 percent each. The elegance of the SuStaIn approach applied here lies in the fact that these ...
COMMENT Just a note. The double mutants are heterozygous for the PSEN1 mutation, making it easy to breed them. We expect homozygous mutants to show even more aggressive pathology. saido 0 ...
COMMENT This interesting paper convincingly shows that elimination of meningeal lymphatics by photoablation increases the amyloid plaque load in the cortices and thalami of 5xFAD mice. However, the claim that “Compromised meningeal lymphatic function in 5xFAD ...
Beaumont HospitalRoyal Oak, United States
PAPER Kulcsarova K, Ventosa JR, Feketeova E, Maretta M, Lesko N, Benca M, Han V, Gombosova L, Baloghova J, Slavkovska M, Brosmanova M, Vancova Z, Lepej J, Rabajdova M, Ambro L, Toth S, Kudela F, Kudela I, Strigacova L, Roskovicova V, Gdovinova Z, Skorvanek M
Comparison in detection of prodromal Parkinson's disease patients using original and updated MDS research criteria in two independent cohorts.Parkinsonism Relat Disord. 2021 Apr 30;87:48-55. PubMed: 33964786
PAPER Cairns LM, Rankin J, Hamad A, Cooper N, Merrifield K, Jain V, Rosser E, Rogers M, Buston S, Stopford C, Jones G, Lefroy H, Németh AH, Holden S, Douglas AG
Genetic testing in motor neuron disease and frontotemporal dementia: a 5-year multicentre evaluation.J Med Genet. 2021 May 7; PubMed: 33963046
PAPER Subota A, Jetté N, Josephson CB, McMillan J, Keezer MR, Gonzalez-Izquierdo A, Holroyd-Leduc J
Risk factors for dementia development, frailty, and mortality in older adults with epilepsy- A population-based analysis.Epilepsy Behav. 2021 May 5;120:108006. PubMed: 33964541
PAPER Kwon D33963316
PAPER Saathoff J, Green J, Jiang Y, Xu Y, Kellogg GE, Zhang S
Structural understanding of 5-(4-hydroxy-phenyl)-N-(2-(5-methoxy-1H-indol-3-yl)-ethyl)-3-oxopentanamide as a neuroprotectant for Alzheimer's disease.Bioorg Med Chem Lett. 2021 May 5;:128081. PubMed: 33964442
PAPER Dong PL, Li Z, Teng CL, Yin X, Cao XK, Han H
Syntheses and neuroprotective effects evolution of oxymatrine derivatives as anti-Alzheimer's disease agents.Chem Biol Drug Des. 2021 May 7; PubMed: 33963669
PAPER de Farias JM, Dos Santos Tramontin N, Pereira EV, de Moraes GL, Furtado BG, Tietbohl LT, Da Costa Pereira B, Simon KU, Muller AP
Physical Exercise Training Improves Judgment and Problem-Solving and Modulates Serum Biomarkers in Patients with Alzheimer's Disease.Mol Neurobiol. 2021 May 7; PubMed: 33963521
PAPER Barbuti PA, Barker RA, Brundin P, Przedborski S, Papa SM, Kalia LV, Mochizuki H, MDS Scientific Issues Committee
Recent Advances in the Development of Stem-Cell-Derived Dopaminergic Neuronal Transplant Therapies for Parkinson's Disease.Mov Disord. 2021 May 8; PubMed: 33963552
PAPER Shen S, Wang X, Lv H, Shi Y, Xiao L