PAPER Janbek J, Laursen TM, Frimodt-Møller N, Magyari M, Haas JG, Lathe R, Waldemar G
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PAPER Fotouhi M, Worrall D, Ayoubi R, Southern K, McPherson PS, Laflamme C, NeuroSGC/YCharOS/EDDU collaborative group, ABIF Consortium
A guide to selecting high-performing antibodies for RNA-binding protein TIA1 for use in Western Blot, immunoprecipitation and immunofluorescence.
F1000Res. 2023;12:745. Epub 2024 Apr 8 PubMed: 38638178Interventions to Reduce Sleep Health Disparities (R01- Clinical Trials Optional) (PAR-24-110)
GRANT Friday, April 19, 2024- 3:30pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-24-110.html 08 Sep 2027
Tau Toggling Peptides: One Seeds Fibrils; the Other Dismantles Them
RESEARCH NEWS 2024-04-19 Research News The accumulation of neurofibrillary tangles is the common thread among all tauopathies, yet each amasses fibrils with a distinct fold at their core. What forces goad tau into twisting into these specific folds in the first place, and once fi
PAPER Ponia SS, Robertson SJ, McNally KL, Subramanian G, Sturdevant GL, Lewis M, Jessop F, Kendall C, Gallegos D, Hay A, Schwartz C, Rosenke R, Saturday G, Bosio CM, Martens C, Best SM
Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues.
Cell Rep. 2021 Oct 26;37(4):109888. PubMed: 34706234PAPER Martella G, Platania P, Vita D, Sciamanna G, Cuomo D, Tassone A, Tscherter A, Kitada T, Bonsi P, Shen J, Pisani A
Enhanced sensitivity to group II mGlu receptor activation at corticostriatal synapses in mice lacking the familial parkinsonism-linked genes PINK1 or Parkin.
Exp Neurol. 2009 Feb;215(2):388-96. Epub 2008 Nov 21 PubMed: 19071114PAPER Denk D, Petrocelli V, Conche C, Drachsler M, Ziegler PK, Braun A, Kress A, Nicolas AM, Mohs K, Becker C, Neurath MF, Farin HF, Buchholz CJ, Andreux PA, Rinsch C, Greten FR
Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy.
Immunity. 2022 Nov 8;55(11):2059-2073.e8. Epub 2022 Oct 19 PubMed: 36351375PAPER Cairns G, Thumiah-Mootoo M, Abbasi MR, Racine J, Lariovov N, Prola A, Khacho M, Burelle Y
PINK1 Deficiency Alters Muscle Stem Cell Fate Decision And Muscle Regenerative Capacity.
bioRxiv2023.06.23.546123PAPER Mu J, Zhang D, Tian Y, Xie Z, Zou MH
BRD4 inhibition by JQ1 prevents high-fat diet-induced diabetic cardiomyopathy by activating PINK1/Parkin-mediated mitophagy in vivo.
J Mol Cell Cardiol. 2020 Dec;149:1-14. Epub 2020 Sep 15 PubMed: 32941882PAPER Li J, Dang X, Franco A, Dorn GW 2nd
Reciprocal Regulation of Mitofusin 2-Mediated Mitophagy and Mitochondrial Fusion by Different PINK1 Phosphorylation Events.
Front Cell Dev Biol. 2022;10:868465. Epub 2022 May 12 PubMed: 35646911PAPER Billia F, Hauck L, Konecny F, Rao V, Shen J, Mak TW
PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function.
Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9572-7. Epub 2011 May 23 PubMed: 21606348PAPER Martella G, Madeo G, Schirinzi T, Tassone A, Sciamanna G, Spadoni F, Stefani A, Shen J, Pisani A, Bonsi P
Altered profile and D2-dopamine receptor modulation of high voltage-activated calcium current in striatal medium spiny neurons from animal models of Parkinson's disease.
Neuroscience. 2011 Mar 17;177:240-51. Epub 2010 Dec 31 PubMed: 21195752PAPER Hou K, Ge P, Sawaya MR, Dolinsky JL, Yang Y, Jiang YX, Lutter L, Boyer DR, Cheng X, Pi J, Zhang J, Lu J, Yang S, Yu Z, Feigon J, Eisenberg DS
How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimers disease brain by a strain-relief mechanism
bioRxiv2024.03.25.586668Keystone Symposium- Drug Delivery to the Brain: Emerging Modalities
CONFERENCE 2025-02-17 00:00:00-2025-02-20 00:00:00 Keystone, Colorado 17 – 20 February 2025 View Conference Website 0
Rubbing Microglia the Right Way? At ADPD, Scientists Showcase New Strategies
CONFERENCE COVERAGE 2024-04-19 Conference Coverage Microglia seem to play a hand in every aspect of Alzheimer’s pathogenesis, from the seeding and clearing of plaques to the traveling of tau to the dying of neurons. Scientists are pursuing therapeutics that both promote their neuroprot
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