PAPER Diaz-Galvan P, Ferreira D, Cedres N, Falahati F, Hernández-Cabrera JA, Ames D, Barroso J, Westman E

Comparing different approaches for operationalizing subjective cognitive decline: impact on syndromic and biomarker profiles.

Sci Rep. 2021 Feb 23;11(1):4356. PubMed: 33623075

PAPER Giannini LA, Peterson C, Ohm D, Xie SX, McMillan CT, Raskovsky K, Massimo L, Suh E, Van Deerlin VM, Wolk DA, Trojanowski JQ, Lee EB, Grossman M, Irwin DJ

Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology.

Acta Neuropathol Commun. 2021 Feb 23;9(1):30. PubMed: 33622418

PAPER Nous A, Engelborghs S, Smolders I

Melatonin levels in the Alzheimer's disease continuum: a systematic review.

Alzheimers Res Ther. 2021 Feb 23;13(1):52. PubMed: 33622399

PAPER Phillips MC, Deprez LM, Mortimer GM, Murtagh DK, McCoy S, Mylchreest R, Gilbertson LJ, Clark KM, Simpson PV, McManus EJ, Oh JE, Yadavaraj S, King VM, Pillai A, Romero-Ferrando B, Brinkhuis M, Copeland BM, Samad S, Liao S, Schepel JA

Randomized crossover trial of a modified ketogenic diet in Alzheimer's disease.

Alzheimers Res Ther. 2021 Feb 23;13(1):51. PubMed: 33622392

Richard Mayeux on Massive GWAS Meta-Analysis Digs Up Trove of Alzheimer’s Genes

COMMENT GWAS finds regions in the genome, not genes per se. The difficult part is actually finding the underlying causal variant. However, we are obtaining a full picture of locations in the genome that may harbor important genetic variants that would facilitate ...

Carlos Cruchaga on Massive GWAS Meta-Analysis Digs Up Trove of Alzheimer’s Genes

COMMENT This work is clearly a tour de force, but also a good example of what can be achieved through broad collaboration. It is worth noting that identifying genes or genetic regions just for the sake of it is useless. The important aspect is that the genes ...

Nancy Ip on Massive GWAS Meta-Analysis Digs Up Trove of Alzheimer’s Genes

COMMENT Undertaking genetic studies to identify causal factors for Alzheimer’s disease (AD) requires sufficient sample size and detailed analysis. In this study led by Bellenguez and Lambert et al., genome-wide association analysis (GWAS) based on imputed array ...

John Hardy on Massive GWAS Meta-Analysis Digs Up Trove of Alzheimer’s Genes

COMMENT It is great to see new putative genetic risk loci. Two issues: Are these new genetic risk loci certain? And how much of the genetic risk has been found? On the first point: The power of “simple GWAS” is that the statistical test is easy to understand. Its ...

Yun Chen

Washington University School of Medicine
St. Louis, United States

Yun Chen, Marco Colonna on Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer's disease.

COMMENT This new, exciting study from the Howell lab unveils an interesting correlation between wild-derived mouse genetic variants and their microglia profile in the APP/PS1 model of amyloid pathology. While microglia in B6.APP/PS1, CAST.APP/PS1, and PWK.APP/PS1 ...

Xiaowen Ding

Auburn University
Auburn, United States

Alzheimer’s Association Interdisciplinary Summer Research Institute (AA-ISRI)

CONFERENCE 2021-08-09 00:00:00-2021-08-13 00:00:00 Chicago, Illinois 09 &#x2013 13 August 2021 Training Program View Conference Website 0 ...

Holly Brothers

Biogen
Canton, United States

UCSF Postdoctoral Scholar

JOB 2021-02-25 Employer University of California, San Francisco Principal Investigator Michael Weiner Contact Interested candidates, please send your CV and two references to: Rachel Nosheny, Ph.D., at Rachel.nosheny@ucsf.edu. Description The postdoctoral scholar will ...

Laura Nuttin

Belgium