JOB 2020-07-09 Employer ASU-Banner Neurodegenerative Disease Research Center at Arizona State University Principal Investigator Ben Readhead Contact Application Instructions: Applicants are responsible for including a cover letter, CV, and the names of three ...
JOB 2020-07-09 Employer Columbia University Irving Medical Center Principal Investigator Abid Hussaini Contact firstname.lastname@example.org Description The Taub Institute for Research on Alzheimer’s disease and the Aging Brain is seeking a Postdoctoral Scientist to join the ...
University of California, IrvineIrvine, United States
COMMENT C.C. Fan et al. developed and examined a sex-stratified polygenic score for prediction of AD age of onset and other AD phenotypes, including AD pathological hallmarks. Their study expands recently published GWAS papers, exploring genes that were ...
MUTATIONS PSEN1 73637540 GRCh37 (105) A T Exon 4 Point, Missense Coding Unknown. Unknown, but in one patient, MRI showed moderate frontal cortex atrophy, PiB-PET no amyloid deposition, FDG-PET mild hypometabolism in the lateral temporal lobe. CSF Aβ and tau were ...
Rush University Medical CenterChicago, United States
COMMENT These results are very promising and are consistent with our previous paper, where we found evidence for associations between amyloid and intellectual enrichment in those who are highly educated (Vemuri et al., 2016). However, it was surprising to see no ...
PAPER Chen S, Wang T, Yao J, Brinton RD
Allopregnanolone Promotes Neuronal and Oligodendrocyte Differentiation In Vitro and In Vivo: Therapeutic Implication for Alzheimer's Disease.Neurotherapeutics. 2020 Jul 6; PubMed: 32632771
PAPER Pérez MJ, Ivanyuk D, Panagiotakopoulou V, Di Napoli G, Kalb S, Brunetti D, Al-Shaana R, Kaeser SA, Fraschka SA, Jucker M, Zeviani M, Viscomi C, Deleidi M
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids.Mol Psychiatry. 2020 Jul 7; PubMed: 32632204
PAPER Bono-Yagüe J, Gómez-Escribano AP, Millán JM, Vázquez-Manrique RP32630706
PAPER Escamilla-Ayala AA, Sannerud R, Mondin M, Poersch K, Vermeire W, Paparelli L, Berlage C, Koenig M, Chavez-Gutierrez L, Ulbrich MH, Munck S, Mizuno H, Annaert W
Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface.Elife. 2020 Jul 7;9 PubMed: 32631487
PAPER Chen L, Huang GL, Lü MH, Zhang YX, Xu J, Bai SP
Amide derivatives of Gallic acid: Design, synthesis and evaluation of inhibitory activities against in vitro α-synuclein aggregation.Bioorg Med Chem. 2020 Aug 1;28(15):115596. Epub 2020 Jun 17 PubMed: 32631566
PAPER Urbizu A, Beyer K
Epigenetics in Lewy Body Diseases: Impact on Gene Expression, Utility as a Biomarker, and Possibilities for Therapy.Int J Mol Sci. 2020 Jul 2;21(13) PubMed: 32630630
PAPER Santos GS, Oyadomari WY, Carvalho EA, Torquato RS, Oliveira V
Prolyl Endopeptidase-Like Facilitates the α-Synuclein Aggregation Seeding, and This Effect Is Reverted by Serine Peptidase Inhibitor PMSF.Biomolecules. 2020 Jun 25;10(6) PubMed: 32630529
PAPER Abramov AY, Potapova EV, Dremin VV, Dunaev AV32629809