PAPER Nam U, Lee K, Ko H, Lee JY, Lee EC32961984
PAPER Ryckman AE, Brockhausen I, Walia JS
Metabolism of Glycosphingolipids and Their Role in the Pathophysiology of Lysosomal Storage Disorders.Int J Mol Sci. 2020 Sep 19;21(18) PubMed: 32961778
PAPER Monastero R, Baschi R, Nicoletti A, Pilati L, Pagano L, Cicero CE, Zappia M, Brighina F
Transcranial random noise stimulation over the primary motor cortex in PD-MCI patients: a crossover, randomized, sham-controlled study.J Neural Transm (Vienna). 2020 Sep 23; PubMed: 32965593
PAPER Audira G, Ngoc Anh NT, Ngoc Hieu BT, Malhotra N, Siregar P, Villalobos O, Villaflores OB, Ger TR, Huang JC, Chen KH, Hsiao CD
Evaluation of the Adverse Effects of Chronic Exposure to Donepezil (An Acetylcholinesterase Inhibitor) in Adult Zebrafish by Behavioral and Biochemical Assessments.Biomolecules. 2020 Sep 18;10(9) PubMed: 32962160
COMMENT This is a very nice example of functional follow-up of a genetic association study finding. I am very happy that this is taking place (it’s why we are performing the studies) and of course I am pleased it looks like the genetic association studies were ...
COMMENT Takalo et al. present an interesting paper on an AD-associated protective variant in PLCG2 by making a Plcγ2-P522R knock-in (KI) mouse model. The authors showed that the Plcγ2-P522R mutation increased PLCγ signaling and promoted phagocytosis, survival, ...
COMMENT A P522R coding variant in the PLCγ2 gene was recently demonstrated to reduce the risk of Alzheimer’s disease (AD). This study by Takalo et al. is the first to examine how the P522R variant impacts microglial activity in vivo and it provides additional ...
RESEARCH NEWS 2020-09-24 Research News Microglia can help or hinder in Alzheimer’s disease. A protective variant of the microglial gene phospholipase C-γ2 (PLCG2) may shed light on what makes the difference. In the September 11 Molecular Neurodegeneration, researchers led by ...
PAPER Rao Y32632254
Alzheimer's Association of Central and North FloridaThe Villages, United States
PAPER Supattapone S32958241
PAPER Baskakov IV32958238
PAPER Spagnolli G, Requena JR, Biasini E32958233
PAPER Ellett LJ, Revill ZT, Koo YQ, Lawson VA32958230
PAPER Knight R32958229