PAPER Goveas JS33839012
PAPER Somberg NH, Gelenter MD, Hong M
Comparative analysis of 13C chemical shifts of β-sheet amyloid proteins and outer membrane proteins.J Biomol NMR. 2021 May;75(4-5):151-166. Epub 2021 Apr 12 PubMed: 33844106
PAPER Kapadia A, Desai P, Dmytriw A, Maralani P, Heyn C, Black S, Symons S, Alzheimer’s Disease Neuroimaging Initiative
In vivo detection of beta-amyloid at the nasal cavity and other skull-base sites: a retrospective evaluation of ADNI1/GO.Ann Nucl Med. 2021 Jun;35(6):728-734. Epub 2021 Apr 12 PubMed: 33844185
PAPER Cheng B, Li X, Dai K, Duan S, Rong Z, Chen Y, Lü L, Liu Z, Huang X, Xu H, Zhang YW, Zheng H
Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival.Front Immunol. 2021;12:633796. Epub 2021 Mar 25 PubMed: 33841415
Shane Liddelow, Philip Hasel on Squelching ApoE in Astrocytes of Tau-Ravaged Mice Dampens Degeneration
COMMENT This is an exciting set of data from the Holtzman group that adds another piece to the puzzle of APOE’s role as a risk factor for Alzheimer’s Disease (AD). In this paper, Wang et al. use the P301S mouse model of AD, expressing either ApoE3 or ApoE4, and ...
MUTATIONS PSEN1 73653585 GRCh37/hg19--- ATA Exon 6 Duplicaton Coding Unknown, but in silico algorithms (PROVEAN and SIFT) predicted pathogenicity and CADD score was 20.2. Neuropatholgoy consistent with AD in one case. I168dup Alzheimer's Disease: Likely ...
National Institutes of HealthBethesda, United States
COMMENT Two comments: 1) This study, however impressive, has a limitation: There is no Aβ pathology. Aβ uptake by astrocytes damages their endolysosomal system (Sanchez-Mico et al., 2021). Thus, the question is: How would astrocytes damaged by Aβ respond to Tau ...
JOB 2021-04-12 Employer University of Texas Medical Branch at Galveston Principal Investigator Agenor Limon Contact firstname.lastname@example.org Description Essential Job Functions: Limon lab uses pioneering methods to understand electrical and chemical responses of human neural ...
Sam Gandy, Michelle Ehrlich on Squelching ApoE in Astrocytes of Tau-Ravaged Mice Dampens Degeneration
COMMENT The new study in Neuron by Wang and colleagues, led by David Holtzman, Washington University, St. Louis, strengthens the evidence that APOE4 acts not only by gain of toxic function, but that APOE4 promotes multiple features of the classical Alzheimer’s ...
NYUNew York, United States
Baylor College of MedicineHouston, United States
Williamsburg, United States