PAPER Sachs BC, Latham LA, Bateman JR, Cleveland MJ, Espeland MA, Fischer E, Gaussoin SA, Leng I, Rapp SR, Rogers S, Shappell HM, Williams BJ, Yang M, Craft S

Feasibility of Remote Administration of the Uniform Data Set-Version 3 for Assessment of Older Adults With Mild Cognitive Impairment and Alzheimer's Disease.

Arch Clin Neuropsychol. 2024 Jan 30; PubMed: 38291734

Jingchun Chen

University of Nevada, Las Vegas
Las Vegas, United States

Gizem Terzioglu

Harvard Medical School/Brigham and Women's Hospital
Boston, United States

Jingcheng Zhao on First Evidence for Transmitted Alzheimer’s Disease?

COMMENT As far as I know, this is the first evidence supporting that Alzheimer’s (and not just CAA) is transmissible in humans. If Alzheimer’s were to be transmissible, that would certainly open up a range of questions and concerns, including whether other, more

Jingcheng Zhao

Karolinska Institutet
Stockholm, Sweden

First Evidence for Transmitted Alzheimer’s Disease?

RESEARCH NEWS 2024-01-31 Research News Research over the last decade has shown that aggregated Aβ seeds can be transferred between people during rare medical procedures, sparking amyloidosis in the recipient. Could this result in full-blown Alzheimer’s disease? In the January 29

Marc Diamond on First Evidence for Transmitted Alzheimer’s Disease?

COMMENT The Collinge group has performed a measured, thoughtful, and careful report of dementia following iatrogenic exposure of people to pituitary extracts that contained Aβ seeding activity. The story is compelling to the extent that the group of patients were

Dieter Willbold on First Evidence for Transmitted Alzheimer’s Disease?

COMMENT If self-replicating protein aggregates are the trigger for Alzheimer's disease, then the disease must in principle be transmissible. It is as simple as that. After the transmissibility of the pathology has been demonstrated in animals and humans, the

Steven Collins, Colin Masters on First Evidence for Transmitted Alzheimer’s Disease?

COMMENT Iatrogenic Alzheimer’s disease: a medical misadventure? Premised on our current understanding of the continuum of pathogenic changes in AD evolution, the U.K. National Prion Monitoring Cohort (NPMC) now reports eight cases of likely young-onset (38-55 yea

Ville Leinonen on First Evidence for Transmitted Alzheimer’s Disease?

COMMENT The study is extremely interesting on the hot topic of potential transmission of Aβ in similar fashion as prion protein. The advent of acquired “mad cow” disease led to new standards of instrument handling when CJD is suspected. This has arguably led to s

Giovanna Lalli on First Evidence for Transmitted Alzheimer’s Disease?

COMMENT This very interesting paper is, as far as I know, the first demonstration of potential iatrogenic AD; previous cases had pointed to iatrogenic CAA. As cases are extremely rare, I think more research is warranted. The findings are not entirely surprising g

Seth Love on First Evidence for Transmitted Alzheimer’s Disease?

COMMENT This carefully considered, well-argued analysis of a small case series strongly suggests that iatrogenic transmission of Aβ in the course of human cadaver-derived pituitary growth hormone replacement therapy can induce not only CAA and diffuse Aβ plaques

Barbara E. Stopschinski on First Evidence for Transmitted Alzheimer’s Disease?

COMMENT This is a very thorough report on a group of patients who received human cadaveric pituitary-derived growth hormone containing Aβ seeds in childhood for variable conditions and developed early onset of dementia with AD-like features in their 40s and 50s.

Gael Nicolas on First Evidence for Transmitted Alzheimer’s Disease?

COMMENT This interesting report asks the critical important question, based on previous data in human and mice, of finding clinical cases of iatrogenic AD in cadaveric pituitary-derived growth hormone recipients beyond the reports of Aβ deposits in brains of indi

Herbert Budka on First Evidence for Transmitted Alzheimer’s Disease?

COMMENT This work continues the clinical follow-up of a U.K. cohort of at least 1,848 individuals who had been treated during childhood with cadaver-derived growth hormone (Swerdlow et al., 2003). The cohort has emerged as an invaluable tool to allow a new glimps