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Benjamin Wolozin on Islands of Tau Coat and Protect Cytoskeleton

COMMENT These papers by Siahaan et al. and Tan et al. add to a growing body of work emphasizing the importance of phase separation in biology, and the specific importance of this work in tau biology. Previous work by the Hyman laboratory demonstrated the ...

Kenneth Kosik on Islands of Tau Coat and Protect Cytoskeleton

COMMENT Phase states of tau can regulate microtubule function These new tau papers advance our knowledge of tau protein function at a mechanistic level. Previous work showed that tau is an RNA-binding protein capable of undergoing liquid-liquid phase separation ...

Jürgen Götz on Islands of Tau Coat and Protect Cytoskeleton

COMMENT Both studies elegantly identify novel interactions between tau and microtubules (MTs) in a physiological setting, either in regulating tau condensation or in protecting MTs from depolymerizing. I have been reminded of a paper from the Safinya lab on the ...

Islands of Tau Coat and Protect Cytoskeleton

RESEARCH NEWS 2019-09-06 Research News Two papers in the September 2 Nature Cell Biology present complementary evidence that tau condenses into a patchwork of rafts that coat microtubules. These patches share some properties with phase-separated liquid droplets of tau that have ...

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