PAPER Bratke S, Schmid S, Ulm B, Jungwirth B, Blobner M, Borgstedt L
SEARCH RESULTS
331009 RESULTS
PAPER Moguilner S, Herzog R, Perl YS, Medel V, Cruzat J, Coronel C, Kringelbach M, Deco G, Ibáñez A, Tagliazucchi E
Biophysical models applied to dementia patients reveal links between geographical origin, gender, disease duration, and loss of neural inhibition.
Alzheimers Res Ther. 2024 Apr 11;16(1):79. PubMed: 38605416PAPER Coulombe B, Durcan TM, Bernard G, Moursli A, Poitras C, Faubert D, Pinard M
The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases.
Mol Brain. 2024 Apr 11;17(1):18. PubMed: 38605409PAPER Aragón-González A, Shaw AC, Kok JR, Roussel FS, Santos Souza CD, Granger SM, Vetter T, de Diego Y, Meyer KC, Beal SN, Shaw PJ, Ferraiuolo L
C9ORF72 patient-derived endothelial cells drive blood-brain barrier disruption and contribute to neurotoxicity.
Fluids Barriers CNS. 2024 Apr 11;21(1):34. PubMed: 38605366PAPER Ogonowski NS, García-Marín LM, Fernando AS, Flores-Ocampo V, Rentería ME
Impact of genetic predisposition to late-onset neurodegenerative diseases on early life outcomes and brain structure.
Transl Psychiatry. 2024 Apr 11;14(1):185. PubMed: 38605018Min Soo Kang
Korea, Republic of
Esteban Cruz
The University of QueenslandBrisbane, Australia
Dervis Salih on Easing Microglial Brakes Alleviates Amyloid Pathology in Mice
COMMENT This is an exciting study by Hou and colleagues showing that modulating LILRB4 using an antibody likely inhibits LILRB4 binding to APOE, activating microglia and attenuating Aβ-related measures, such as plaque load and neuronal dystrophy. This study follo
Martine Therrien on Easing Microglial Brakes Alleviates Amyloid Pathology in Mice
COMMENT Microglia with unique transcriptional signatures have been identified in Alzheimer’s disease patients and animal models (Keren-Shaul et al., 2017). Understanding the regulation and impact of these states is essential if we want to know how to modulate mic
Renzo Mancuso on Easing Microglial Brakes Alleviates Amyloid Pathology in Mice
COMMENT This is very interesting work, as it dives into the plethora of receptors that control microglial function. For very good reasons, the field has focused extensively on some specific molecules, such as TREM2 or CD33, but microglia express a vast diversity
Easing Microglial Brakes Alleviates Amyloid Pathology in Mice
RESEARCH NEWS 2024-04-11 Research News Rather than giving them more gas, can microglia be driven to clear amyloid plaques by letting up on their brakes? Yes, say scientists led by Marco Colonna at Washington University in St. Louis. In the April 3 Science Translational Medicine,
PAPER Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, He L, Chen Y, Chen H, Luo W, Lu Z, Xie J, Churchill H, Xu Y, Zhou Z, Wu G, Yu C, John S, Hirayasu K, Nguyen N, Liu X, Huang F, Li L, Deng H, Tang H, Sadek AH, Zhang L, Huang T, Zou Y, Chen B, Zhu H, Arase H, Xia N, Jiang Y, Collins R, You MJ, Homsi J, Unni N, Lewis C, Chen GQ, Fu YX, Liao XC, An Z, Zheng J, Zhang N, Zhang CC
LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration.
Nature. 2018 Oct;562(7728):605-609. Epub 2018 Oct 17 PubMed: 30333625Ben Chih
United States
P-tau217 Immunotherapy Alleviates Tangle Pathology in Mice
RESEARCH NEWS 2024-04-11 Research News Phosphotau-217 has emerged as one of the most promising diagnostic markers of Alzheimer’s disease. It might also be a good therapeutic target, say scientists led by Yingjun Zhao at Xiamen University in China. In the March 20 Neuron, they rep
Jasmine Nguyen
Current Filters
No filters selected