Cathepsin B

ANTIBODY polyclonal manufacturer Cat# LS-C21357 immunogen = mature form cathepsin B, purified from human liver DEAE-column chromatography cathepsin B pro- and mature forms Proteases LifeSpan Biosciences, Inc. Rabbit Human Cathepsin B http://alzforum.org/res/com/an

Andre Delacourte on Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms.

COMMENT Tau is a MAP and indirectly a thermometer, modified by temperature, stress, hypo- or hypermetabolism, etc. This is an interesting paper showing that modeling tauopathy for AD studies is tricky. 0 andre.delacourte

Terrence Town on Postnatal Neurogenesis Tied in with Presenilins, Ephrin Signaling

COMMENT The paper by Breunig et al. represents an elegant set of experiments, performed by a talented young investigator and aimed at dissecting the molecular mechanisms responsible for postnatal neurogenesis. Using tamoxofen-inducible Notch1 knockout mice and in

Chris Carter on Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: relevance to pathological-signalling cascades.

COMMENT Supplementary information for this paper is available at the PolygenicPathways site. This includes details of the interactions of HSV-1 with host transcription factors and a listing of their downstream targets in relation to genes implicated in Alzheimer

Kiumars Lalezarzadeh on Environmental adaptations improve everyday action performance in Alzheimer's disease: empirical support from performance-based assessment.

COMMENT Giovannetti et al. (2007) clarify certain performance anticipation issues in Alzheimer patients. Habituation or “environmental adaptation” improves performance in many behavioral studies. The improvement is mainly related to the desensitization to irrelev

Paul Coleman on Plaque-bearing mice with reduced levels of oligomeric amyloid-beta assemblies have intact memory function.

COMMENT An interesting differentiation of the effect of plaques versus Abeta oligomers on memory. 0 Paul_Coleman

nhat duong

United States

Paul Coleman on Biomarkers for early detection of Alzheimer pathology.

COMMENT It seems this review emphasizes CSF and imaging biomarkers and their potential to detect disease "while the symptoms of brain failure are mild". Although these classes of biomarker have utility in research and offer importance insights into dise

Jürgen Götz on Membrane-bound beta-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism.

COMMENT This interesting paper brings together the tyrosine kinase fyn, tau, and Abeta. The authors position fyn upstream of tau, with Abeta oligomers triggering, via fyn and tau, a rearrangement of actin, which causes a redistribution of Abeta on the cell surfac

Jürgen Götz on Alzheimer's disease: advances in trafficking.

COMMENT Concise round-up on SORL1, a potential AD risk gene encoding a protein involved in Golgi/endosome trafficking. 0 j.goetz

Fred Van Leuven on Enabling Technologies for Alzheimer Disease Research: Seventh Bar Harbor Workshop, 2007, Part 5

COMMENT I appreciate many, not all, of the items in the list of "hot-topics-to-be-tackled-by-fundamental-AD-research" (part 5 of Gabrielle's relentless account of the "Bar-Harbor-top"). That said, I am surprised to encounter the term &quo

Francisco Centeno

Universidad de Extremadura. Faculty of Science
Badajoz, Spain

Daniel Gonzalez

Karolinska Institutet
Stockholm, Sweden

p53

ANTIBODY polyclonal manufacturer Cat# LS-C25907 immunogen = synthetic peptide corresp. to a portion of human p53 p53 p53 LifeSpan Biosciences, Inc. Rabbit Human p53 http://alzforum.org/res/com/ant/default.asp?antibodyID=25070

p53

ANTIBODY monoclonal manufacturer Cat# LS-C25902 immunogen = murine p53 wild type oncogene protein A purified; conj. to FITC p53 wild-type only p53 LifeSpan Biosciences, Inc. Mouse Human p53 http://alzforum.org/res/com/ant/default.asp?antibodyID=25069