Claudia Almeida on Ceramide triggers budding of exosome vesicles into multivesicular endosomes.

COMMENT This very interesting paper by Mikael Simons and colleagues identifies a novel mechanism for the inward budding of multivesicular bodies (MVBs). MVBs are crucial intermediates in the trafficking of ubiquitinated receptors and other cargo destined for degr

PAPER Raposo G, Marks MS

Melanosomes--dark organelles enlighten endosomal membrane transport.

Nat Rev Mol Cell Biol. 2007 Oct;8(10):786-97. PubMed: 17878918

PAPER Hanson PI, Roth R, Lin Y, Heuser JE

Plasma membrane deformation by circular arrays of ESCRT-III protein filaments.

J Cell Biol. 2008 Jan 28;180(2):389-402. PubMed: 18209100

PAPER Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brügger B, Simons M

Ceramide triggers budding of exosome vesicles into multivesicular endosomes.

Science. 2008 Feb 29;319(5867):1244-7. PubMed: 18309083

TARDPB /TDP-43

ANTIBODY polyclonal manufacturer 10782-2-AP<br />References:<br />(<a href="/papers/tar-dna-binding-protein-43-tdp-43-associates-stress-granules-analysis-cultured-cells-and" target="_new">Liu-Yesucevitz, 2010</a>, unspec

2008 MetLife Award for De Strooper, Vassar, Wong

COMMUNITY NEWS 2008-03-04 Community News With this year’s Awards for Medical Research in Alzheimer’s Disease, the MetLife Foundation recognized three scientists who advanced knowledge of the β- and γ-secretase enzymes and in this way helped build a foundation for much of today’s w

TGF-β1

ANTIBODY kit manufacturer Cat# 650.010.096 pre-coated 12 strip plate, biotinylated 2nd antibody, stds, buffers, streptavin-HRP, substrate, stop reagent recognizes both natural and recombinant human TGF-β1 others not tested Transforming Growth Factor (TGF) Cell Sci

praveena raman

United States

Wendy Wilson

University of British Columbia
Vancouver, Canada

PAPER Chung J, Nguyen AK, Henstridge DC, Holmes AG, Chan MH, Mesa JL, Lancaster GI, Southgate RJ, Bruce CR, Duffy SJ, Horvath I, Mestril R, Watt MJ, Hooper PL, Kingwell BA, Vigh L, Hevener A, Febbraio MA

HSP72 protects against obesity-induced insulin resistance.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1739-44. PubMed: 18223156

PAPER Beaulieu JM, Marion S, Rodriguiz RM, Medvedev IO, Sotnikova TD, Ghisi V, Wetsel WC, Lefkowitz RJ, Gainetdinov RR, Caron MG

A beta-arrestin 2 signaling complex mediates lithium action on behavior.

Cell. 2008 Jan 11;132(1):125-36. PubMed: 18191226

PAPER Kang JS, Tian JH, Pan PY, Zald P, Li C, Deng C, Sheng ZH

Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation.

Cell. 2008 Jan 11;132(1):137-48. PubMed: 18191227

PAPER Mercer TR, Dinger ME, Sunkin SM, Mehler MF, Mattick JS

Specific expression of long noncoding RNAs in the mouse brain.

Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):716-21. PubMed: 18184812

SNAP 25

ANTIBODY polyclonal manufacturer Cat# HPA001830, Prestige Antibodies™, Powered by Atlas Antibodies immunogen = SNAP 25 recomb. protein epitope signature tag (PrEST) solution, affinity isolated, PBS, glycerol, azide synaptosomal associated protein 25 (SNAP 25) Syna

SNAP 25 (SP 12)

ANTIBODY monoclonal SP 12 manufacturer Cat# S5187 immunogen = crude human synaptic precipitate buffered aqueous solution, purified IgG, PBS, azide synaptosomal associated protein 25 (SNAP 25) IgG₁ Synaptic Vesicle Fusion Sigma Aldrich Mouse