330988 RESULTS
COMMENT Extend the exclusive use provision of the FDA Orphan Drug Act (ODA) to AD drugs. When a new mechanism of drug action is hypothesized as potentially effective, old compounds, which affect that mechanism and are safe to use, are often the best candidates fo
COMMENT The primary impediment to small firms entering the Alzheimer disease drug development market is lack of private funds. Called the "Valley of Death," the space between basic research and clinical trials lacks private funds because of the extraord
COMMENT We see people who are very interested in participating in clinical trials, but they want to get into the most promising active treatment trials, not something like a prevention via exercise study. They are asking for the most promising trials. Do we dare
COMMENT CMS stands to benefit hugely from any successful development of efficacious interventions for prevention. They should be highly motivated to facilitate prevention research. We could start by clarifying that CMS will pay for clinical evaluation when the ne
COMMENT Two endpoints should not be a problem, if one of the endpoints is reduced incidence of dementia. Dementia by definition implies functional impairment, which fills the need for a second endpoint. john.breitner 0
COMMENT If we have a chance to come back to methodologic dilemmas confronting Primary Prevention trials, it may be worth noting that it's possible to measure endpoints from trial populations that are very widely dispersed geographically. Think of ADAMS with
United States
PAPER Tolar M, Keller JN, Chan S, Mattson MP, Marques MA, Crutcher KA
Massachusetts General HospitalCharlestown, United States
ANTIBODY polyclonal manufacturer Cat# P60101-0<br />Reference: <br /><a href="/papers/hsp104-antagonizes-alpha-synuclein-aggregation-and-reduces-dopaminergic-degeneration-rat" target="_new">Lo Bianco, 2008</a> immunogen
West China Hospital of Sichuan UniversityChengdu, China
RESEARCH NEWS 2008-11-03 Research News Slipping your car into reverse while barreling down the highway is hardly good practice. Neither is simultaneously stomping on the gas pedal and the brake. But when it comes to driving the cell cycle, that might just be what presenilins, the
PAPER Kannangara TS, Webber A, Gil-Mohapel J, Christie BR
PAPER Zoghbi HY, Orr HT
PAPER Ayala YM, Zago P, D'Ambrogio A, Xu YF, Petrucelli L, Buratti E, Baralle FE
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