Stephen Flitman

21st Century Neurology, a divison of Xenoscience Inc.
Phoenix, United States

Michael Vitek on Brain Drain—E4 Less Stable Than Other ApoE Isoforms

COMMENT Compelling and widely accepted genetic evidence shows that the presence of one or more APOE4 genes is associated with more severe disease in Alzheimer’s, stroke, traumatic brain injury, multiple sclerosis, and many others. The question is, How does APOE4/

PAPER Riddell DR, Zhou H, Atchison K, Warwick HK, Atkinson PJ, Jefferson J, Xu L, Aschmies S, Kirksey Y, Hu Y, Wagner E, Parratt A, Xu J, Li Z, Zaleska MM, Jacobsen JS, Pangalos MN, Reinhart PH

Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels.

J Neurosci. 2008 Nov 5;28(45):11445-53. PubMed: 18987181

J. Lucy Boyd on Let There Be Sunlight—Melanogenesis as a Model for AD?

COMMENT I recommend the primary paper. FNightingale512 0

Lucie Guessan

Abidjan

Brain Drain—E4 Less Stable Than Other ApoE Isoforms

RESEARCH NEWS 2008-11-07 Research News If a gene allele clearly raises risk for a devastating disease, it might seem a no-brainer to assume that the variant protein contributes to pathogenesis, and that correcting this rogue factor could help restore normality. But in the case of

PAPER Thakker-Varia S, Alder J

Neuropeptides in depression: role of VGF.

Behav Brain Res. 2009 Feb 11;197(2):262-78. PubMed: 18983874

PAPER Pettersson-Kastberg J, Aits S, Gustafsson L, Mossberg A, Storm P, Trulsson M, Persson F, Mok KH, Svanborg C

Can misfolded proteins be beneficial? The HAMLET case.

Ann Med. 2009;41(3):162-76. PubMed: 18985467

PAPER Pankratz N, Wilk JB, Latourelle JC, DeStefano AL, Halter C, Pugh EW, Doheny KF, Gusella JF, Nichols WC, Foroud T, Myers RH,

Genomewide association study for susceptibility genes contributing to familial Parkinson disease.

Hum Genet. 2009 Jan;124(6):593-605. PubMed: 18985386

PAPER Shoichet SA, Waibel S, Endruhn S, Sperfeld AD, Vorwerk B, Müller I, Erdogan F, Ludolph AC, Ropers HH, Ullmann R

Identification of candidate genes for sporadic amyotrophic lateral sclerosis by array comparative genomic hybridization.

Amyotroph Lateral Scler. 2009 Jun;10(3):162-9. PubMed: 18985462

PAPER Kimura R, Silva AJ, Ohno M

Autophosphorylation of alphaCaMKII is differentially involved in new learning and unlearning mechanisms of memory extinction.

Learn Mem. 2008 Nov;15(11):837-43. PubMed: 18984565

PAPER Fang Q, Strand A, Law W, Faca VM, Fitzgibbon MP, Hamel N, Houle B, Liu X, May DH, Poschmann G, Roy L, Stühler K, Ying W, Zhang J, Zheng Z, Bergeron JJ, Hanash S, He F, Leavitt BR, Meyer HE, Qian X, McIntosh MW

Brain-specific proteins decline in the cerebrospinal fluid of humans with Huntington disease.

Mol Cell Proteomics. 2009 Mar;8(3):451-66. PubMed: 18984577

PAPER Lee CY, Lee CH, Shih CC, Liou HH

Paraquat inhibits postsynaptic AMPA receptors on dopaminergic neurons in the substantia nigra pars compacta.

Biochem Pharmacol. 2008 Oct 30;76(9):1155-64. PubMed: 18761327

PAPER Weber IT, Fang B, Agniswamy J

Caspases: structure-guided design of drugs to control cell death.

Mini Rev Med Chem. 2008 Oct;8(11):1154-62. PubMed: 18855730

PAPER Martin B, Golden E, Carlson OD, Pistell P, Zhou J, Kim W, Frank BP, Thomas S, Chadwick WA, Greig NH, Bates GP, Sathasivam K, Bernier M, Maudsley S, Mattson MP, Egan JM

Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease.

Diabetes. 2009 Feb;58(2):318-28. PubMed: 18984744