PAPER Hasegawa M, Jakes R, Crowther RA, Lee VM, Ihara Y, Goedert M
COMMENT These papers by Senatorov et al. and Milikovsky et al. demonstrate that BBB dysfunction initiates neuronal dysfunction, supporting the growing body of evidence that BBB breakdown contributes to synaptic dysfunction, neurodegeneration, and cognitive ...
PAPER Rabender C, Mezzaroma E, Mauro AG, Mullangi R, Abbate A, Anscher M, Hart B, Mikkelsen R
IPW-5371 Proves Effective as a Radiation Countermeasure by Mitigating Radiation-Induced Late Effects.Radiat Res. 2016 Nov;186(5):478-488. PubMed: 27841740
Baylor College of MedicineHouston, United States
PAPER Weissberg I, Wood L, Kamintsky L, Vazquez O, Milikovsky DZ, Alexander A, Oppenheim H, Ardizzone C, Becker A, Frigerio F, Vezzani A, Buckwalter MS, Huguenard JR, Friedman A, Kaufer D
Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood-brain barrier dysfunction.Neurobiol Dis. 2015 Jun;78:115-25. Epub 2015 Mar 30 PubMed: 25836421
PAPER Kim SY, Senatorov VV Jr, Morrissey CS, Lippmann K, Vazquez O, Milikovsky DZ, Gu F, Parada I, Prince DA, Becker AJ, Heinemann U, Friedman A, Kaufer D
TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults.Sci Rep. 2017 Aug 9;7(1):7711. PubMed: 28794441
PAPER Ivens S, Kaufer D, Flores LP, Bechmann I, Zumsteg D, Tomkins O, Seiffert E, Heinemann U, Friedman A
TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis.Brain. 2007 Feb;130(Pt 2):535-47. Epub 2006 Nov 21 PubMed: 17121744
PAPER Cacheaux LP, Ivens S, David Y, Lakhter AJ, Bar-Klein G, Shapira M, Heinemann U, Friedman A, Kaufer D19605630
PAPER Senatorov VV Jr, Friedman AR, Milikovsky DZ, Ofer J, Saar-Ashkenazy R, Charbash A, Jahan N, Chin G, Mihaly E, Lin JM, Ramsay HJ, Moghbel A, Preininger MK, Eddings CR, Harrison HV, Patel R, Shen Y, Ghanim H, Sheng H, Veksler R, Sudmant PH, Becker A, Hart B, Rogawski MA, Dillin A, Friedman A, Kaufer D
Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction.Sci Transl Med. 2019 Dec 4;11(521) PubMed: 31801886
PAPER Milikovsky DZ, Ofer J, Senatorov VV Jr, Friedman AR, Prager O, Sheintuch L, Elazari N, Veksler R, Zelig D, Weissberg I, Bar-Klein G, Swissa E, Hanael E, Ben-Arie G, Schefenbauer O, Kamintsky L, Saar-Ashkenazy R, Shelef I, Shamir MH, Goldberg I, Glik A, Benninger F, Kaufer D, Friedman A
Paroxysmal slow cortical activity in Alzheimer's disease and epilepsy is associated with blood-brain barrier dysfunction.Sci Transl Med. 2019 Dec 4;11(521) PubMed: 31801888
JOB 2019-12-06 Employer Boston University Contact Interested candidates should send a CV, cover letter explaining goals and motivations, and contact information for three references to both of the following email addresses: Mikel Garcia-Marcos, Associate Professor. ...
Part the Cloud (PTC) Bioenergetics/Mitochondria, Clearance Related, Vascular Contributions and Inflammation Clinical Trials Program
GRANT Friday, December 6, 2019- 11:00 The Alzheimer's Association Part the Cloud + Bill Gates Partnership Up to $1 million over two years for Phase 1 studies; up to $2 million over two years for Phase 2 studies LOI deadline: January 6, 2020 Part the Cloud ...
Boston University School of MedicineBoston, United States
PAPER Capone C, Cognat E, Ghezali L, Baron-Menguy C, Aubin D, Mesnard L, Stöhr H, Domenga-Denier V, Nelson MT, Joutel A26648042
COMMENT Ever since Anne Cataldo and Ralph Nixon and their many coworkers (one article was cited above) advanced this line of research over 30 years ago, it has been very clear that lysosomal trafficking is critical to the pathology of Alzheimer's disease. ...