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α-Synuclein Spurs Neuroinflammation Via Microglial LRRK2

RESEARCH NEWS 2020-10-30 Research News Scientists believe that in Parkinson’s disease and other synucleinopathies, toxic α- synuclein can escape the confines of damaged dopaminergic neurons, infiltrate neighboring microglia, and set off a neuroinflammatory storm. But what exactly ...

Jean-Charles Lambert on Epigenomic Roadmap Points to Causal Genes

COMMENT This work has several objectives: (i) to establish a systematic mapping of transposase-accessible chromatin (ATAC) regions in seven brain regions from 39 healthy individuals; (ii) from some of the samples used in the previous bulk assay, to perform a ...

Alzheimer's Risk Genes Nip at Hippocampus Throughout Life

RESEARCH NEWS 2020-10-30 Research News Alzheimer’s disease risk variants lurk within the genome from the beginning of life, but at what age do they start to do their dirty work on the brain? According to a study published in the October issue of Neurology Genetics, AD genetic ...

Race Against Dementia Fellowship Webinar (RAD/ARUK)

CONFERENCE 2020-11-16 00:00:00-2020-11-16 00:00:00 Online Meeting 16 November 2020 Organizers: Race Against Dementia (RAD) and Alzheimer’s Research UK (ARUK) Time: 2 pm ET View Conference Website 0 ...

Epigenomic Roadmap Points to Causal Genes

RESEARCH NEWS 2020-10-30 Research News Genetic-association studies link loci—certain addresses in a person’s DNA—to disease, but finding the causal genes within those regions is anything but straightforward. In the October 26 Nature Genetics, researchers led by Thomas Montine and ...

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