Brain Barriers Virtual (BBV) 2020: "Engineering large molecule drug delivery to the brain: Transport vehicles for antibodies and enzymes”

CONFERENCE 2020-08-12 00:00:00-2020-08-12 00:00:00 Online Meeting 12 August 2020 Organizers: Bjoern Bauer, University of Kentucky, Anika Hartz, University of Kentucky, Brandon Kim, University of Wisconsin, Madison Speaker: Robert Thorne, PhD, Denal Therapeutics and University of Minnesota Meeting time: 12 ...

Heart Health Is Brain Health, and It Starts in Your 20s

CONFERENCE COVERAGE 2020-08-07 Conference Coverage Having established that poor cardiovascular health in midlife increases the risk of cognitive decline and dementia as a person ages, scientists are now pushing to see if the same relationship might hold true even earlier in life. ...

PAPER Schaum N, Lehallier B, Hahn O, Pálovics R, Hosseinzadeh S, Lee SE, Sit R, Lee DP, Losada PM, Zardeneta ME, Fehlmann T, Webber JT, McGeever A, Calcuttawala K, Zhang H, Berdnik D, Mathur V, Tan W, Zee A, Tan M, Tabula Muris Consortium, Pisco AO, Karkanias J, Neff NF, Keller A, Darmanis S, Quake SR, Wyss-Coray T

Ageing hallmarks exhibit organ-specific temporal signatures.

Nature. 2020 Jul;583(7817):596-602. Epub 2020 Jul 15 PubMed: 32669715

PAPER Laurent JS, Watts R, Adise S, Allgaier N, Chaarani B, Garavan H, Potter A, Mackey S

Associations Among Body Mass Index, Cortical Thickness, and Executive Function in Children.

JAMA Pediatr. 2019 Dec 9; PubMed: 31816020

PAPER Tampio J, Huttunen J, Montaser A, Huttunen KM

Targeting of Perforin Inhibitor into the Brain Parenchyma Via a Prodrug Approach Can Decrease Oxidative Stress and Neuroinflammation and Improve Cell Survival.

Mol Neurobiol. 2020 Nov;57(11):4563-4577. Epub 2020 Aug 5 PubMed: 32754897

PAPER King A, Szekely B, Calapkulu E, Ali H, Rios F, Jones S, Troakes C

The Increased Densities, But Different Distributions, of Both C3 and S100A10 Immunopositive Astrocyte-Like Cells in Alzheimer's Disease Brains Suggest Possible Roles for Both A1 and A2 Astrocytes in the Disease Pathogenesis.

Brain Sci. 2020 Jul 31;10(8) PubMed: 32751955

PAPER Germann UA, Alam JJ

P38α MAPK Signaling-A Robust Therapeutic Target for Rab5-Mediated Neurodegenerative Disease.

Int J Mol Sci. 2020 Jul 31;21(15) PubMed: 32751991

PAPER Yuan G, Cui S, Chen X, Song H, Huang C, Tong J, Yuan Z, Yu L, Xiong X, Zhao J, Huang B, Wu Q, Zhou Y, Chen G, Zhou H, Xia XG

Detergent-insoluble inclusion constitutes the first pathology in PFN1 transgenic rats.

J Neurochem. 2020 Aug 5; PubMed: 32754913

PAPER Pytte J, Flynn LL, Anderton RS, Mastaglia FL, Theunissen F, James I, Pfaff A, Koks S, Saunders AM, Bedlack R, Burns DK, Lutz MW, Siddique N, Siddique T, Roses AD, Akkari PA

Disease-modifying effects of an SCAF4 structural variant in a predominantly SOD1 ALS cohort.

Neurol Genet. 2020 Aug;6(4):e470. Epub 2020 Jul 1 PubMed: 32754644

PAPER Lv J, Lu C, Jiang N, Wang H, Huang H, Chen Y, Li Y, Liu X

Protective effect of ginsenoside Rh2 on scopolamine-induced memory deficits through regulation of cholinergic transmission, oxidative stress and the ERK-CREB-BDNF signaling pathway.

Phytother Res. 2020 Aug 4; PubMed: 32754961

PAPER Jiang B, Bi M, Li J, Liu Q, Xiao NA, Fang J, Shi MY, Yu ZW, Ma QL, Tong SJ, Zheng KM

A Pathogenic Variant p.Phe177Val in PSEN1 Causes Early-Onset Alzheimer's Disease in a Chinese Family.

Front Genet. 2020;11:713. Epub 2020 Jul 10 PubMed: 32754199

PAPER Vasilevskaya A, Taghdiri F, Multani N, Anor C, Misquitta K, Houle S, Burke C, Tang-Wai D, Lang AE, Fox S, Slow E, Rusjan P, Tartaglia MC

PET Tau Imaging and Motor Impairments Differ Between Corticobasal Syndrome and Progressive Supranuclear Palsy With and Without Alzheimer's Disease Biomarkers.

Front Neurol. 2020;11:574. Epub 2020 Jul 10 PubMed: 32754109

PAPER Nevone A, Merlini G, Nuvolone M

Treating Protein Misfolding Diseases: Therapeutic Successes Against Systemic Amyloidoses.

Front Pharmacol. 2020;11:1024. Epub 2020 Jul 10 PubMed: 32754033

PAPER Xiyang YB, Liu R, Wang XY, Li S, Zhao Y, Lu BT, Xiao ZC, Zhang LF, Wang TH, Zhang J

COX5A Plays a Vital Role in Memory Impairment Associated With Brain Aging via the BDNF/ERK1/2 Signaling Pathway.

Front Aging Neurosci. 2020;12:215. Epub 2020 Jul 10 PubMed: 32754029

PAPER Teitsdottir UD, Jonsdottir MK, Lund SH, Darreh-Shori T, Snaedal J, Petersen PH

Association of glial and neuronal degeneration markers with Alzheimer's disease cerebrospinal fluid profile and cognitive functions.

Alzheimers Res Ther. 2020 Aug 4;12(1):92. PubMed: 32753068