COMMENT This is a very nice example of functional follow-up of a genetic association study finding. I am very happy that this is taking place (it’s why we are performing the studies) and of course I am pleased it looks like the genetic association studies were ...
COMMENT Takalo et al. present an interesting paper on an AD-associated protective variant in PLCG2 by making a Plcγ2-P522R knock-in (KI) mouse model. The authors showed that the Plcγ2-P522R mutation increased PLCγ signaling and promoted phagocytosis, survival, ...
COMMENT A P522R coding variant in the PLCγ2 gene was recently demonstrated to reduce the risk of Alzheimer’s disease (AD). This study by Takalo et al. is the first to examine how the P522R variant impacts microglial activity in vivo and it provides additional ...
RESEARCH NEWS 2020-09-24 Research News Microglia can help or hinder in Alzheimer’s disease. A protective variant of the microglial gene phospholipase C-γ2 (PLCG2) may shed light on what makes the difference. In the September 11 Molecular Neurodegeneration, researchers led by ...
PAPER Rao Y32632254
Alzheimer's Association of Central and North FloridaThe Villages, United States
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