11174 RESULTS
COMMENT We are excited to see the work of Chou et al. suggesting a link between INPP5D and inflammasomes (Chou et al., 2023). Their findings dovetail nicely with our recent paper, which found the INPP5D in human brain has multiple transcription start sites and tw
COMMENT This is an interesting study to obtain additional insight into the higher prevalence of Alzheimer’s disease in women than men. Mice with transgenic CYP46A1 overexpression were used, and sex-specific behavioral changes were correlated with dendritic spine
COMMENT This is an interesting study by the Maioli lab, with possibly important implications for stratifying patients in AD trials with cholesterol-targeting interventions. Over the last year, our understanding of the links between cholesterol, AD risk genes, and
COMMENT (referencing Dr. Fox's comment). I have a hunch that hipp. vol. + MMSE + CDR-SB in a supervised model
COMMENT Perhaps the BrainSee algorithm is detecting thinning of cortical gray matter as in Satizabal et al., 2023. That said, a blood draw is easier for most patients than an MRI, and plasma p-tau217 immunoassay detects AD with 90-95 percent accuracy (Ashton et a
COMMENT In a side-by-side comparison between BrainSee and hippocampal volume to predict progression to AD-dementia in 409 aMCI patients, hippocampal volume performed with 65.0 percent sensitivity, 78.2 percent specificity and 71.6 percent balanced accuracy; Brain
COMMENT Until a century ago, most people used to die before the age of 50 with few exceptions, suggesting our creator did not expect us to live long enough to suffer from late-onset Alzheimer’s disease (LOAD). Kotredes and colleagues have tried to generate a mous
COMMENT According to Alzforum, there are 204 murine models of AD, showing the complexity of developing a model that mimics AD perfectly. The choice of the best mouse model depends on the specific questions researchers aim to address; there is no universally perfe
COMMENT Tau double phosphorylation at residues 202 and 205 is one of the hallmarks of brain tau aggregates and has been used over the last decades for neuropathological studies on tau aggregation using the AT8 antibody. In cerebrospinal fluid, multiple phosphoryl
COMMENT This new report by Franzmeier et al. is a beautiful continuation of investigations into the important interplay between Aβ, tau, and neuronal hyperexcitability in the context of Alzheimer's disease. There have long been reports of how the presence of
COMMENT In this paper, the authors conducted an interesting secondary analysis of CSF and longitudinal tau PET data from ADNI. CSF levels of GAP-43, a presynaptic protein important in neurodevelopment and in axonal regeneration, are increased in MCI and AD, and h
COMMENT The take-home message from this research article is that in AD, synaptic changes, manifested by increased levels of the presynaptic protein GAP-43, are closely associated with the accelerated spread of tau pathology. The study found that higher levels of
COMMENT The recent article by Franzmeier et al. demonstrated, with a series of very elegant analyses, that the synaptic biomarker GAP-43 associates with the spreading and accumulation of Aβ-related tau pathology. The study somewhat challenges the perhaps more “tr
COMMENT Nobuhisa Iwata, a former member of my laboratory and currently professor of Nagasaki University, quantified plasma Aβ40 and 42 in wild-type and neprilysin knockout mice. Aβ40 and 42 were 1.6 and 1.7 times higher in the knockout mice, respectively, and the
COMMENT The term neurovascular coupling was coined in 2001 to indicate the interaction between brain activity and brain blood supply. While approximately a century ago it was believed that the vessels supplying blood to the brain and the brain cells function inde
