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David Teplow on What Makes Amyloid Sticky?

COMMENT Among the most difficult problems for those interested in understanding the structural biology of amyloidoses are how to determine the complete three-dimensional structure of amyloid fibrils and to monitor the protein folding events leading to formation ...

Alexei Koudinov on Diagnosing the Early Stages of Alzheimer's

COMMENT This very interesting article presents important knowledge on how the apoE isoforms affect brain function, memory, and memory dysfunction. The functional aspect is a major plus, as it extends the simplistic consideration of seeing the role of apoE in ...

Keith Crutcher on Diagnosing the Early Stages of Alzheimer's

COMMENT This is a very good overview of the use of psychophysics to probe cognitive tasks that might be sensitive to early changes in AD. The finding that specific aspects of visual attention vary as a function of apoE genotype is especially intriguing. The ...

Douglas Galasko on Diagnosing the Early Stages of Alzheimer's

COMMENT The three papers examine the important issue of whether subtle changes in psychometric measures can provide predictors as early as 3-5 years before patients develop an "end point" such as mild dementia or mild cognitive impairment (MCI). Many ...

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