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Dominic Walsh on Fog Beginning to Clear on Aβ-Degrading Enzymes?

COMMENT Aβ-degrading enzymes—many candidates, but few fit the bill This comment extends the news report filed directly from the meeting to provide a more detailed description of this emerging area. To date, a number of potential Aβ-degrading enzymes have been ...

Chris Exley on Fog Beginning to Clear on Aβ-Degrading Enzymes?

COMMENT This news report does not mention that the serine protease at the centre of the urokinase-plasminogen activator system, namely plasmin, is selective for Aβ 42 and in cleaving Aβ 42 prevents its aggregation into β-pleated sheet structures (see Exley and ...

Rajiv Ratan on Is It the Curry?

COMMENT I liked the paper very much. It is generally well done and suggests an easy intervention that could reduce AD onset or progression without significant toxicity. Among the questions it raises are: 1.) How does the concentration of curcumin that is ...

Benjamin Wolozin on Aβ Abets α-Synuclein

COMMENT α-Synuclein and β-amyloid: A Linking of Partners to Model Disease Creating transgenic models of neurodegenerative disease has yielded mixed results. The transgenic models of Huntington's chorea and amyotrophic lateral sclerosis have yielded animal ...

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