Hiroshi Mori on Interaction of Alzheimer beta-amyloid peptide(1-40) with lipid membranes.

COMMENT A-beta1-40 is one of cerebral amyloid species and believed to be associated with APOE allele e4. Any information for an interaction of this amyloid species with other molecules is welcome to understand AD pathogenesis. mori 0 ...

Hiroshi Mori on Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms.

COMMENT Phosphorylation could be a factor in regulating the different functions of the two presenilin molecules. mori 0 ...

Paul Coleman on Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease.

COMMENT This is consistent with other studies suggesting the significance of APO E may not be through an action on the neuropil. Paul_Coleman 0 ...

Hiroshi Mori on Apolipoprotein E and Tau phosphorylation in human neuroblastoma cells.

COMMENT It is noteworthy that tau phosphorylation is independent of apoE allelic function. mori 0 ...

Hiroshi Mori on Melatonin prevents beta-amyloid-induced lipid peroxidation.

COMMENT Free radicals are potent factors to induce neruopathogenesis of AD and should be examined from variable views. This reports on multiple functions for melatonin to attenuate radical oxidation reaction. mori 0 ...

Paul Coleman on Role of sphingolipid-mediated cell death in neurodegenerative diseases.

COMMENT The role of lipid-dependent signaling systems in apoptosis of a variety of systems has been known for some time. Although this review may not contain new information it can serve the purpose of emphasizing the potential importance of this signalling ...

Paul Coleman on Neuropathology of three clinical cases prospectively diagnosed as dementia with Lewy bodies.

COMMENT A contribution to the difficult problem of diagnosis of LBD. Paul_Coleman 0 ...

Edward Koo on Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta.

COMMENT More non-abeta related amyloid pathology. This extends the interesting British dementia reported several years ago. edkoo 0 ...

Zaven Khachaturian on Secreted glypican binds to the amyloid precursor protein of Alzheimer's disease (APP) and inhibits APP-induced neurite outgrowth.

COMMENT This paper is important because it provides further evidence for the neuroprotective role of APP. Mechanisms of neurite outgrowth are important areas of research in developing treatments for AD. zaven_khachaturian 0 ...

Benjamin Wolozin on SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease.

COMMENT New associations between ApoE and AD bwolozin 0 ...

Edward Koo on Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation.

COMMENT Obviously this technology has been around and we know it will work. But this is the first time this has been used for select for embryo free of one genetic disease. Start of a slippery slope? edkoo 0 ...

Hiroshi Mori on Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations.

COMMENT The paper tells something about the molecular mechanism for ApoE function by evidence that ApoE influences development of dementia rather than onset time. mori 0 ...

Michael Schlossmacher on Presenting: A Not-Quite-Parkinson's Mouse Model

COMMENT As is often the case with transgenic rodent models of human neurodegenerative diseases, a single strain of genetically engineered animals rarely recapitulates the entire pathological spectrum associated with the human phenotype. The same is true for the ...

Ratan Bhat on Wingless Pathway Helps Tauopathy Take Off

COMMENT This paper describes an extremely important and exciting result that clearly demonstrates for the first time that both human tau as well as the Drosophila homolog of GSK3b, (a kinase implicated in abnormal tau phosphorylation) are essential for ...

Inez Vincent on The Cell Cycle and Alzheimer’s Disease—Let's Unite for Division!

COMMENT Reply from Inez Vincent Definitely, this would be worthwhile. Recent data supports the idea that phosphorylation of APP at the thr668 site alters its interaction with Fe65, and beta-amyloid production (Ando, 2001). What needs to be determined is which ...