8772 RESULTS
COMMENT This is an excellent study providing new insights and a rich resource on TREM2-dependent glial responses in AD in mice and humans. One highlight of the study is the description of reactive oligodendrocytes in the 5xFAD mouse model of AD. Using snRNAseq, ...
COMMENT This is a very informative and important paper. We should remember that there are no "mouse models of AD." Maybe we will never see any animal model that fully mimics Alzheimer’s disease (see Walker and Jucker, 2017). What we have are mouse ...
COMMENT The study by Allnutt et al. reports the application of a computational approach for the detection of microbial sequences to two existing RNA-sequence data sets (MSBB and ROSMAP) to examine potential microbial associations with Alzheimer’s disease. The ...
COMMENT This work by Allnut et al. complements our analysis on whether HHV6 and 7 are elevated in AD brains compared to control. Our analysis is focused on the validity of the method used to test whether there is a statistical significance to the HHV virus level ...
COMMENT As compared to the Readhead paper, which with sophisticated bioinformatics tools proved a functional association with AD and its viral risk factors, here Jacobson and colleagues use a single bioinformatic pipeline, utilizing the same data set and same ...
COMMENT We have known for some time that Aβ and tau interact with each other and that Aβ can trigger and exacerbate tau pathology, but the molecular mechanisms have not been fully defined. The present study shows that Aβ oligomers (Aβ o) can act as a positive ...
COMMENT I wish to congratulate Zhou et al. for this exceptional article. One of the genes that attracted my attention was SERPINA3 (aka alpha-1-antichymotrypsin). We published that alpha-1-antichymotrypsin (ACT) was intimately associated with amyloid plaques in ...
COMMENT This a wonderful discussion of an important topic in the vascular contributions to dementia. It is important to contextualize that these results pertain specifically to atherosclerosis and not other forms of vascular dysfunction. Gottesman et al. is ...
COMMENT Among the now several “-omics” papers on Alzheimer’s disease that have emerged in the last few years, this new report by Zhou et al. stands out because of its comprehensive analysis of mouse and human tissue at the single-cell level. One of the more ...
COMMENT This study from Yingyue Zhou from the Colonna lab is exactly the sort of study that the field should be doing more of—comparing actual human transcriptomic analyses with those from animal models is the key to determining which cell types (or subtypes of ...
COMMENT This extensive and well-performed study by Koper et al. shows an interesting novel feature of GVBs, as their core is immunopositive for necrosomes. As the authors and commentators indicate, caution is warranted with mechanistic interpretation based on ...
COMMENT Overall I think this is a beautiful study. It makes a clear point that immune components are essential for our understanding of Alzheimer’s disease. Whether these are causal factors or part of the repair mechanism, or a repair system that went wrong, it ...
COMMENT This study raises three major questions: Do neurons undergo a delayed slow necroptosis in AD? If so, how do microglia respond? And do microglia undergo necroptosis in AD? The authors demonstrate co-localization of activated necrosome components within ...
COMMENT This was a very nice study of AD patients and control brain samples, showing the presence of pRIPK1, pRIPK3, and pMLKL in granulovacuolar degeneration (GVD) of neuronal cells. The analyses are solid and convincing. Although differences exist with regard ...
COMMENT I think the demonstration of necrosomes’ positive granulovacuolar degeneration (GVDn+) in AD brains is interesting and new, and opens up new lines of research and potentially new therapeutic targets. However, I think the mechanistic relationship between ...
