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Samuel Gandy on Intracellular Aβ in Alzheimer's Disease

COMMENT The idea that intracellular Aβ injures neurons and causes dementia prior to the formation of extracellular deposits is not obviously reconcilable with other evidence indicating that "full-blown" structural pathology precedes dementia (Crystal H, ...

Brian Balin on Chlamydia Update

COMMENT This letter is in response to the recent article in Journal of Clinical Microbiology (38[2]:881-882, 2000) entitled "Failure to detect Chlamydia pneumoniae in brain sections of Alzheimer's Disease Patients" by Gieffers et al. Since we were ...

David Teplow on Toxic Protofibrillar Aβ

COMMENT In the news article cited above, two important facts need clarification. First, protofibrils are fibrillar. Second, the first demonstration that protofibrils were neurotoxic was published by my group, in collaboration with Drs. Hartley, Selkoe, and others ...

Peter St. George-Hyslop on The A2M Deletion, Revisited

COMMENT The final sentences of the Alzheimer Research Forum News Summary leaves the impression that the cause of the disparity is due to differences in the statistical methods used. In fact, this is not at all correct. The Rogaeva et al paper used the SAME family ...

Rudy Tanzi on The A2M Deletion, Revisited

COMMENT Response from Rudy Tanzi In Peter Hyslop's reply to the Alzheimer Forum News article on "A2M Revisited," he states: "The Rogaeva et al paper used the SAME family based association statistical methods as Blacker et al (ie the SDT and s ...

Rudy Tanzi on The A2M Deletion, Revisited

COMMENT Thanks for summarizing the three new A2M genetics papers and our reply in Nature Genetics (May 1999) in your "News" section this month. I wanted to share my thoughts on the controversy regarding the candidacy of A2M as a genetic risk factor for ...

Allen Roses on The A2M Deletion, Revisited

COMMENT Response from Allen Roses et al. to Tanzi Comment Below please find a short, absolute rebuttal to the comments made by Rudy Tanzi. It is followed by a fairly detailed commentary on each point, including copies of relevant dated correspondence that clarify ...

Larry Sparks on Vitamin E: More Than an Antioxidant?

COMMENT Inflammation, free radicals, and cytokines are involved in a vascular cascade producing the transformation of macrophages into foam cells between the endothelial cell layer and the basement membrane of a blood vessel leading to formation of an ...

Steve Barger on In Search of γ-Secretase

COMMENT Reply by Steven Barger Regardless of whether presenilins really are γ-secretases (for which the data seem to tipping the scales), the data seem quite clear that they are somehow involved in proteolytic processing of both APP and Notch. To me, one of the ...

Johanna Bergmann on In Search of γ-Secretase

COMMENT Reply by E. Preddie and J. Bergmann 1. Considering what was known before, the nature of the experiments done by Wolfe and colleagues and the results obtained, it appears that the conclusion expressed by 'Ye' et al from their results is equally ...

Rudy Tanzi on In Search of γ-Secretase

COMMENT Reply to Ratan Bhat by Rudy Tanzi: The main problem with this hypothesis is that since the time of publication of the commentary by Tuck Finch and I in Science, we now know that PS2 does not bind β- or delta-catenin (Tesco et al., J. Biol Chem., 1998). ...

Ratan Bhat on In Search of γ-Secretase

COMMENT Question from Ratan Bhat There have been suggestions that an increase in beta-catenin could mask some the mutation sites within PS1 (Tanzi and Finch in their Science comment), thereby stabilizing PS1, decreasing γ-secretase activity and subsequently β ...

Dennis Selkoe on In Search of γ-Secretase

COMMENT Reply by Dennis Selkoe Dear John: In response to your News and Views in the 8 April issue of Nature, I thought it would be helpful to indicate several points about your comments regarding the role of presenilins in APP processing with which my colleagues ...

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